MAPK/ERK and JNK pathways regulate lipid synthesis and cell growth of Chlamydomonas reinhardtii under osmotic stress, respectively
Microalgae have great potential for the production of biofuels due to the ability of the organism to accumulate large quantities of storage lipids under stress conditions. Mitogen activated protein kinase (MAPK) signaling cascades are widely recognized for their role in stress response signal transd...
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Published in | Scientific reports Vol. 8; no. 1; pp. 13857 - 12 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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14.09.2018
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Abstract | Microalgae have great potential for the production of biofuels due to the ability of the organism to accumulate large quantities of storage lipids under stress conditions. Mitogen activated protein kinase (MAPK) signaling cascades are widely recognized for their role in stress response signal transduction in eukaryotes. To assess the correlation between MAPK activation and lipid productivity,
Chlamydomonas reinhardtii
was studied under various concentrations of NaCl. The results demonstrated that
C
.
reinhardtii
exhibits elevated levels of extracellular-signal regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) activities after undergoing osmotic stress, as well as an increase in cellular lipid content. To establish a more direct causal link between both kinases and lipid productivity,
C
.
reinhardtii
was subjected to biochemically induced regulation of ERK and JNK pathways. Activating the MEK-ERK pathway via C6 ceramide treatment increased ERK activation and lipid production simultaneously, while PD98059 mediated inhibition of the pathway yielded opposite results. Interestingly, suppression of the JNK pathway with SP600125 resulted in a substantial decrease in cell viability under osmotic stress. These results suggest that ERK and JNK MAP kinases have important roles in microalgal lipid accumulation and cell growth under osmotic stress, respectively. |
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AbstractList | Abstract Microalgae have great potential for the production of biofuels due to the ability of the organism to accumulate large quantities of storage lipids under stress conditions. Mitogen activated protein kinase (MAPK) signaling cascades are widely recognized for their role in stress response signal transduction in eukaryotes. To assess the correlation between MAPK activation and lipid productivity, Chlamydomonas reinhardtii was studied under various concentrations of NaCl. The results demonstrated that C . reinhardtii exhibits elevated levels of extracellular-signal regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) activities after undergoing osmotic stress, as well as an increase in cellular lipid content. To establish a more direct causal link between both kinases and lipid productivity, C . reinhardtii was subjected to biochemically induced regulation of ERK and JNK pathways. Activating the MEK-ERK pathway via C6 ceramide treatment increased ERK activation and lipid production simultaneously, while PD98059 mediated inhibition of the pathway yielded opposite results. Interestingly, suppression of the JNK pathway with SP600125 resulted in a substantial decrease in cell viability under osmotic stress. These results suggest that ERK and JNK MAP kinases have important roles in microalgal lipid accumulation and cell growth under osmotic stress, respectively. Microalgae have great potential for the production of biofuels due to the ability of the organism to accumulate large quantities of storage lipids under stress conditions. Mitogen activated protein kinase (MAPK) signaling cascades are widely recognized for their role in stress response signal transduction in eukaryotes. To assess the correlation between MAPK activation and lipid productivity, Chlamydomonas reinhardtii was studied under various concentrations of NaCl. The results demonstrated that C . reinhardtii exhibits elevated levels of extracellular-signal regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) activities after undergoing osmotic stress, as well as an increase in cellular lipid content. To establish a more direct causal link between both kinases and lipid productivity, C . reinhardtii was subjected to biochemically induced regulation of ERK and JNK pathways. Activating the MEK-ERK pathway via C6 ceramide treatment increased ERK activation and lipid production simultaneously, while PD98059 mediated inhibition of the pathway yielded opposite results. Interestingly, suppression of the JNK pathway with SP600125 resulted in a substantial decrease in cell viability under osmotic stress. These results suggest that ERK and JNK MAP kinases have important roles in microalgal lipid accumulation and cell growth under osmotic stress, respectively. Microalgae have great potential for the production of biofuels due to the ability of the organism to accumulate large quantities of storage lipids under stress conditions. Mitogen activated protein kinase (MAPK) signaling cascades are widely recognized for their role in stress response signal transduction in eukaryotes. To assess the correlation between MAPK activation and lipid productivity, Chlamydomonas reinhardtii was studied under various concentrations of NaCl. The results demonstrated that C. reinhardtii exhibits elevated levels of extracellular-signal regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) activities after undergoing osmotic stress, as well as an increase in cellular lipid content. To establish a more direct causal link between both kinases and lipid productivity, C. reinhardtii was subjected to biochemically induced regulation of ERK and JNK pathways. Activating the MEK-ERK pathway via C6 ceramide treatment increased ERK activation and lipid production simultaneously, while PD98059 mediated inhibition of the pathway yielded opposite results. Interestingly, suppression of the JNK pathway with SP600125 resulted in a substantial decrease in cell viability under osmotic stress. These results suggest that ERK and JNK MAP kinases have important roles in microalgal lipid accumulation and cell growth under osmotic stress, respectively. |
ArticleNumber | 13857 |
Author | Lee, Bongsoo Yang, Ahreum Suh, William I. Chang, Yong Keun Kang, Nam Kyu |
Author_xml | – sequence: 1 givenname: Ahreum surname: Yang fullname: Yang, Ahreum organization: Department of Chemical and Biomolecular Engineering, KAIST – sequence: 2 givenname: William I. surname: Suh fullname: Suh, William I. organization: Advanced Biomass R&D Center, KAIST – sequence: 3 givenname: Nam Kyu surname: Kang fullname: Kang, Nam Kyu organization: Advanced Biomass R&D Center, KAIST – sequence: 4 givenname: Bongsoo orcidid: 0000-0002-8841-1482 surname: Lee fullname: Lee, Bongsoo email: bongsoolee@kaist.ac.kr organization: Department of Chemical and Biomolecular Engineering, KAIST – sequence: 5 givenname: Yong Keun surname: Chang fullname: Chang, Yong Keun email: changyk@kaist.ac.kr organization: Department of Chemical and Biomolecular Engineering, KAIST, Advanced Biomass R&D Center, KAIST |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30218070$$D View this record in MEDLINE/PubMed |
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Keywords | Reinhardtii Extracellular Signal-regulated Kinase Neutral Lipid Accumulation Environmental Osmotic Stress Lipid Production |
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Snippet | Microalgae have great potential for the production of biofuels due to the ability of the organism to accumulate large quantities of storage lipids under stress... Abstract Microalgae have great potential for the production of biofuels due to the ability of the organism to accumulate large quantities of storage lipids... |
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SubjectTerms | 631/337 631/449/2675 82/80 96/95 Algae Aquatic microorganisms Biofuels c-Jun protein Cell growth Cellular stress response Ceramide Chlamydomonas reinhardtii Environmental Osmotic Stress Eukaryotes Extracellular Signal-regulated Kinase Humanities and Social Sciences JNK protein Kinases Lipid Production Lipids MAP kinase Metabolic pathways multidisciplinary Neutral Lipid Accumulation Osmosis Osmotic stress Protein kinase Reinhardtii Science Science (multidisciplinary) Signal transduction Sodium chloride Transcription factors |
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Title | MAPK/ERK and JNK pathways regulate lipid synthesis and cell growth of Chlamydomonas reinhardtii under osmotic stress, respectively |
URI | https://link.springer.com/article/10.1038/s41598-018-32216-5 https://www.ncbi.nlm.nih.gov/pubmed/30218070 https://www.proquest.com/docview/2104154760 https://search.proquest.com/docview/2105046186 https://pubmed.ncbi.nlm.nih.gov/PMC6138697 https://doaj.org/article/6e2861b80a0b46a0bf34217b610792f5 |
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