Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones

• Published in: PLoS biology Vol. 16; no. 9; p. e3000008
• Main Authors: Phillips, Angela M, Ponomarenko, Anna I, Chen, Kenny, Ashenberg, Orr, Miao, Jiayuan, McHugh, Sean M, Butty, Vincent L, Whittaker, Charles A, Moore, Christopher L, Bloom, Jesse D, Lin, Yu-Shan, Shoulders, Matthew D
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.09.2018; Public Library of Science (PLoS)
• Subjects: Adaptation, Physiological; Amino Acid Sequence; Animals; Biology and Life Sciences; Biophysical Phenomena; DNA Mutational Analysis; Dogs; Host-Pathogen Interactions; Host-virus relationships; Humans; Immune Evasion; Immune system; Immune System - virology; Immunity, Innate; Influenza viruses; Madin Darby Canine Kidney Cells; Medicine and Health Sciences; Microbiological research; Models, Biological; Molecular chaperones; Molecular Chaperones - metabolism; Myxovirus Resistance Proteins - metabolism; Nucleoproteins - chemistry; Orthomyxoviridae - immunology; Physical Sciences; Physiological aspects; Protein Structure, Secondary; Temperature; Viral Proteins - chemistry

The threat of viral pandemics demands a comprehensive understanding of evolution at the host-pathogen interface. Here, we show that the accessibility of adaptive mutations in influenza nucleoprotein at fever-like temperatures is mediated by host chaperones. Particularly noteworthy, we observe that t...