Body temperature measurement in mice during acute illness: implantable temperature transponder versus surface infrared thermometry
Body temperature is a valuable parameter in determining the wellbeing of laboratory animals. However, using body temperature to refine humane endpoints during acute illness generally lacks comprehensiveness and exposes to inter-observer bias. Here we compared two methods to assess body temperature i...
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| Published in | Scientific reports Vol. 8; no. 1; pp. 3526 - 10 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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London
Nature Publishing Group UK
23.02.2018
Nature Publishing Group Nature Portfolio |
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| Abstract | Body temperature is a valuable parameter in determining the wellbeing of laboratory animals. However, using body temperature to refine humane endpoints during acute illness generally lacks comprehensiveness and exposes to inter-observer bias. Here we compared two methods to assess body temperature in mice, namely implanted radio frequency identification (RFID) temperature transponders (method 1) to non-contact infrared thermometry (method 2) in 435 mice for up to 7 days during normothermia and lipopolysaccharide (LPS) endotoxin-induced hypothermia. There was excellent agreement between core and surface temperature as determined by method 1 and 2, respectively, whereas the intra- and inter-subject variation was higher for method 2. Nevertheless, using machine learning algorithms to determine temperature-based endpoints both methods had excellent accuracy in predicting death as an outcome event. Therefore, less expensive and cumbersome non-contact infrared thermometry can serve as a reliable alternative for implantable transponder-based systems for hypothermic responses, although requiring standardization between experimenters. |
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| AbstractList | Body temperature is a valuable parameter in determining the wellbeing of laboratory animals. However, using body temperature to refine humane endpoints during acute illness generally lacks comprehensiveness and exposes to inter-observer bias. Here we compared two methods to assess body temperature in mice, namely implanted radio frequency identification (RFID) temperature transponders (method 1) to non-contact infrared thermometry (method 2) in 435 mice for up to 7 days during normothermia and lipopolysaccharide (LPS) endotoxin-induced hypothermia. There was excellent agreement between core and surface temperature as determined by method 1 and 2, respectively, whereas the intra- and inter-subject variation was higher for method 2. Nevertheless, using machine learning algorithms to determine temperature-based endpoints both methods had excellent accuracy in predicting death as an outcome event. Therefore, less expensive and cumbersome non-contact infrared thermometry can serve as a reliable alternative for implantable transponder-based systems for hypothermic responses, although requiring standardization between experimenters. Abstract Body temperature is a valuable parameter in determining the wellbeing of laboratory animals. However, using body temperature to refine humane endpoints during acute illness generally lacks comprehensiveness and exposes to inter-observer bias. Here we compared two methods to assess body temperature in mice, namely implanted radio frequency identification (RFID) temperature transponders (method 1) to non-contact infrared thermometry (method 2) in 435 mice for up to 7 days during normothermia and lipopolysaccharide (LPS) endotoxin-induced hypothermia. There was excellent agreement between core and surface temperature as determined by method 1 and 2, respectively, whereas the intra- and inter-subject variation was higher for method 2. Nevertheless, using machine learning algorithms to determine temperature-based endpoints both methods had excellent accuracy in predicting death as an outcome event. Therefore, less expensive and cumbersome non-contact infrared thermometry can serve as a reliable alternative for implantable transponder-based systems for hypothermic responses, although requiring standardization between experimenters. Body temperature is a valuable parameter in determining the wellbeing of laboratory animals. However, using body temperature to refine humane endpoints during acute illness generally lacks comprehensiveness and exposes to inter-observer bias. Here we compared two methods to assess body temperature in mice, namely implanted radio frequency identification (RFID) temperature transponders (method 1) to non-contact infrared thermometry (method 2) in 435 mice for up to 7 days during normothermia and lipopolysaccharide (LPS) endotoxin-induced hypothermia. There was excellent agreement between core and surface temperature as determined by method 1 and 2, respectively, whereas the intra- and inter-subject variation was higher for method 2. Nevertheless, using machine learning algorithms to determine temperature-based endpoints both methods had excellent accuracy in predicting death as an outcome event. Therefore, less expensive and cumbersome non-contact infrared thermometry can serve as a reliable alternative for implantable transponder-based systems for hypothermic responses, although requiring standardization between experimenters.Body temperature is a valuable parameter in determining the wellbeing of laboratory animals. However, using body temperature to refine humane endpoints during acute illness generally lacks comprehensiveness and exposes to inter-observer bias. Here we compared two methods to assess body temperature in mice, namely implanted radio frequency identification (RFID) temperature transponders (method 1) to non-contact infrared thermometry (method 2) in 435 mice for up to 7 days during normothermia and lipopolysaccharide (LPS) endotoxin-induced hypothermia. There was excellent agreement between core and surface temperature as determined by method 1 and 2, respectively, whereas the intra- and inter-subject variation was higher for method 2. Nevertheless, using machine learning algorithms to determine temperature-based endpoints both methods had excellent accuracy in predicting death as an outcome event. Therefore, less expensive and cumbersome non-contact infrared thermometry can serve as a reliable alternative for implantable transponder-based systems for hypothermic responses, although requiring standardization between experimenters. |
| ArticleNumber | 3526 |
| Author | Endres, Matthias Banneke, Stefanie Emmrich, Julius Valentin Mei, Jie Grittner, Ulrike Riedel, Nico |
| Author_xml | – sequence: 1 givenname: Jie surname: Mei fullname: Mei, Jie organization: Department of Neurology and Department of Experimental Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health – sequence: 2 givenname: Nico surname: Riedel fullname: Riedel, Nico organization: QUEST – Center for Transforming Biomedical Research, Berlin Institute of Health (BIH) – sequence: 3 givenname: Ulrike surname: Grittner fullname: Grittner, Ulrike organization: Center for Stroke Research, Charité - Universitätsmedizin Berlin, Department of Biostatistics and Clinical Epidemiology, Charité - Universitätsmedizin Berlin – sequence: 4 givenname: Matthias surname: Endres fullname: Endres, Matthias organization: Department of Neurology and Department of Experimental Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Center for Stroke Research, Charité - Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (DZNE), German Center for Cardiovascular Research (DZHK) – sequence: 5 givenname: Stefanie surname: Banneke fullname: Banneke, Stefanie organization: German Federal Institute for Risk Assessment, German Center for the Protection of Laboratory Animals (Bf3R) – sequence: 6 givenname: Julius Valentin orcidid: 0000-0002-3393-0840 surname: Emmrich fullname: Emmrich, Julius Valentin email: julius.emmrich@charite.de organization: Department of Neurology and Department of Experimental Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29476115$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | 631/250/256/2516 64/60 692/308/1426 Body temperature Endotoxins Humanities and Social Sciences Hypothermia Laboratory animals Learning algorithms Lipopolysaccharides multidisciplinary Radio frequency identification Science Science (multidisciplinary) Standardization Surface temperature Temperature effects Temperature measurement Transponders |
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| Title | Body temperature measurement in mice during acute illness: implantable temperature transponder versus surface infrared thermometry |
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