Proteomic identification of serum proteins to induce osteoconductivity of hydroxyapatite

• Published in: Dental Materials Journal Vol. 40; no. 6; pp. 1428 - 1436
• Main Authors: WANG, Yunting, YOSHIDA, Yutaka, KAMIIE, Junichi, SHIWAKU, Yukari, SUZUKI, Osamu, FURUYA, Maiko, YOKOTA, Kotone, KANETAKA, Hiroyasu, YOKOI, Taishi, KAWASHITA, Masakazu
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society for Dental Materials and Devices 25.11.2021; Japanese Society for Dental Materials and Devices; Japan Science and Technology Agency
• Subjects: Aluminum oxide; Angiopoietin; Angiopoietin-like protein 3; Animals; Bioinformatics; Biomedical materials; Blood Proteins; Bone Regeneration; Cell proliferation; Durapatite; Growth factors; Hepatocyte growth factor; Hydroxyapatite; Molecular weight; Osteoblasts; Osteoconduction; Osteoconductivity; Proteins; Proteomic analysis; Proteomics; Rats; Serum proteins; α-Alumina; Hydroxyapatite; Proteomic analysis; α-Alumina; Angiopoietin-like protein 3; Osteoconductivity

We performed proteomic analysis of rat serum proteins adsorbed on hydroxyapatite (HAp) and α-alumina (α-Al2O3) in order to identify proteins that specifically adsorb onto HAp and control cellular responses. Proteins with either or both molecular weight of 22–32 kDa and computed isoelectric point of...