Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice

Breast cancer is the most common type of cancer worldwide and one of the major causes of cancer death in women. Epidemiological studies have established a link between night-shift work and increased cancer risk, suggesting that circadian disruption may play a role in carcinogenesis. Here, we aim to...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 11; no. 1; pp. 3193 - 17
Main Authors Hadadi, Eva, Taylor, William, Li, Xiao-Mei, Aslan, Yetki, Villote, Marthe, Rivière, Julie, Duvallet, Gaelle, Auriau, Charlotte, Dulong, Sandrine, Raymond-Letron, Isabelle, Provot, Sylvain, Bennaceur-Griscelli, Annelise, Acloque, Hervé
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 24.06.2020
Nature Publishing Group
Nature Portfolio
Subjects
13/100
13/21
13/31
38/91
59/5
631/67/1347
631/67/327
631/67/71
631/80/105
64/60
96/63
Animals
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - immunology
Breast Neoplasms - pathology
Cancer
Carcinogenesis
Carcinogens
Cell Transformation, Neoplastic - drug effects
Chronic Disease
Chronobiology Disorders - complications
Chronobiology Disorders - genetics
Chronobiology Disorders - immunology
Circadian rhythms
CXCR2 protein
Cytokines - genetics
Disruption
Epidemiology
Female
Gene Expression Regulation
Health risks
Humanities and Social Sciences
Immunosuppression
Jet lag
Life Sciences
Light Signal Transduction - genetics
Lung cancer
Metastases
Metastasis
Mice
Mice, Transgenic
multidisciplinary
Neoplasm Metastasis - prevention & control
Receptors, Interleukin-8B - antagonists & inhibitors
Receptors, Interleukin-8B - genetics
Science
Science (multidisciplinary)
Shift work
Tumor microenvironment
Tumor Microenvironment - immunology
Tumorigenesis
Tumors
Circadian rhythms
Breast cancer
Cancer stem cells
Cancer microenvironment
Online AccessGet full text
ISSN2041-1723
2041-1723
DOI10.1038/s41467-020-16890-6

Cover

Abstract Breast cancer is the most common type of cancer worldwide and one of the major causes of cancer death in women. Epidemiological studies have established a link between night-shift work and increased cancer risk, suggesting that circadian disruption may play a role in carcinogenesis. Here, we aim to shed light on the effect of chronic jetlag (JL) on mammary tumour development. To do this, we use a mouse model of spontaneous mammary tumourigenesis and subject it to chronic circadian disruption. We observe that circadian disruption significantly increases cancer-cell dissemination and lung metastasis. It also enhances the stemness and tumour-initiating potential of tumour cells and creates an immunosuppressive shift in the tumour microenvironment. Finally, our results suggest that the use of a CXCR2 inhibitor could correct the effect of JL on cancer-cell dissemination and metastasis. Altogether, our data provide a conceptual framework to better understand and manage the effects of chronic circadian disruption on breast cancer progression. Circadian disruption is implicated in the development of different human cancers. Here the authors show that chronic circadian disruption, through continuous jet lag, only moderately affects primary tumour growth but promotes cancer-cell dissemination and metastasis in a mouse model of spontaneous mammary tumorigenesis.
AbstractList Breast cancer is the most common type of cancer worldwide and one of the major causes of cancer death in women. Epidemiological studies have established a link between night-shift work and increased cancer risk, suggesting that circadian disruption may play a role in carcinogenesis. Here, we aim to shed light on the effect of chronic jetlag (JL) on mammary tumour development. To do this, we use a mouse model of spontaneous mammary tumourigenesis and subject it to chronic circadian disruption. We observe that circadian disruption significantly increases cancer-cell dissemination and lung metastasis. It also enhances the stemness and tumour-initiating potential of tumour cells and creates an immunosuppressive shift in the tumour microenvironment. Finally, our results suggest that the use of a CXCR2 inhibitor could correct the effect of JL on cancer-cell dissemination and metastasis. Altogether, our data provide a conceptual framework to better understand and manage the effects of chronic circadian disruption on breast cancer progression.
Breast cancer is the most common type of cancer worldwide and one of the major causes of cancer death in women. Epidemiological studies have established a link between night-shift work and increased cancer risk, suggesting that circadian disruption may play a role in carcinogenesis. Here, we aim to shed light on the effect of chronic jetlag (JL) on mammary tumour development. To do this, we use a mouse model of spontaneous mammary tumourigenesis and subject it to chronic circadian disruption. We observe that circadian disruption significantly increases cancer-cell dissemination and lung metastasis. It also enhances the stemness and tumour-initiating potential of tumour cells and creates an immunosuppressive shift in the tumour microenvironment. Finally, our results suggest that the use of a CXCR2 inhibitor could correct the effect of JL on cancer-cell dissemination and metastasis. Altogether, our data provide a conceptual framework to better understand and manage the effects of chronic circadian disruption on breast cancer progression. Circadian disruption is implicated in the development of different human cancers. Here the authors show that chronic circadian disruption, through continuous jet lag, only moderately affects primary tumour growth but promotes cancer-cell dissemination and metastasis in a mouse model of spontaneous mammary tumorigenesis.
Breast cancer is the most common type of cancer worldwide and one of the major causes of cancer death in women. Epidemiological studies have established a link between night-shift work and increased cancer risk, suggesting that circadian disruption may play a role in carcinogenesis. Here, we aim to shed light on the effect of chronic jetlag (JL) on mammary tumour development. To do this, we use a mouse model of spontaneous mammary tumourigenesis and subject it to chronic circadian disruption. We observe that circadian disruption significantly increases cancer-cell dissemination and lung metastasis. It also enhances the stemness and tumour-initiating potential of tumour cells and creates an immunosuppressive shift in the tumour microenvironment. Finally, our results suggest that the use of a CXCR2 inhibitor could correct the effect of JL on cancer-cell dissemination and metastasis. Altogether, our data provide a conceptual framework to better understand and manage the effects of chronic circadian disruption on breast cancer progression.Breast cancer is the most common type of cancer worldwide and one of the major causes of cancer death in women. Epidemiological studies have established a link between night-shift work and increased cancer risk, suggesting that circadian disruption may play a role in carcinogenesis. Here, we aim to shed light on the effect of chronic jetlag (JL) on mammary tumour development. To do this, we use a mouse model of spontaneous mammary tumourigenesis and subject it to chronic circadian disruption. We observe that circadian disruption significantly increases cancer-cell dissemination and lung metastasis. It also enhances the stemness and tumour-initiating potential of tumour cells and creates an immunosuppressive shift in the tumour microenvironment. Finally, our results suggest that the use of a CXCR2 inhibitor could correct the effect of JL on cancer-cell dissemination and metastasis. Altogether, our data provide a conceptual framework to better understand and manage the effects of chronic circadian disruption on breast cancer progression.
Breast cancer is the most common type of cancer worldwide and one of the major causes of cancer death in women. Epidemiological studies have established a link between night-shift work and increased cancer risk, suggesting that circadian disruption may play a role in carcinogenesis. Here, we aim to shed light on the effect of chronic jetlag (JL) on mammary tumour development. To do this, we use a mouse model of spontaneous mammary tumourigenesis and subject it to chronic circadian disruption. We observe that circadian disruption significantly increases cancer-cell dissemination and lung metastasis. It also enhances the stemness and tumour-initiating potential of tumour cells and creates an immunosuppressive shift in the tumour microenvironment. Finally, our results suggest that the use of a CXCR2 inhibitor could correct the effect of JL on cancer-cell dissemination and metastasis. Altogether, our data provide a conceptual framework to better understand and manage the effects of chronic circadian disruption on breast cancer progression.Circadian disruption is implicated in the development of different human cancers. Here the authors show that chronic circadian disruption, through continuous jet lag, only moderately affects primary tumour growth but promotes cancer-cell dissemination and metastasis in a mouse model of spontaneous mammary tumorigenesis.
Circadian disruption is implicated in the development of different human cancers. Here the authors show that chronic circadian disruption, through continuous jet lag, only moderately affects primary tumour growth but promotes cancer-cell dissemination and metastasis in a mouse model of spontaneous mammary tumorigenesis.
ArticleNumber 3193
Author Duvallet, Gaelle
Auriau, Charlotte
Dulong, Sandrine
Raymond-Letron, Isabelle
Hadadi, Eva
Acloque, Hervé
Aslan, Yetki
Li, Xiao-Mei
Bennaceur-Griscelli, Annelise
Taylor, William
Rivière, Julie
Villote, Marthe
Provot, Sylvain
Author_xml – sequence: 1
  givenname: Eva
  orcidid: 0000-0002-5253-814X
  surname: Hadadi
  fullname: Hadadi, Eva
  email: eva.hadadi@inserm.fr
  organization: Inserm, U935, Université Paris Sud
– sequence: 2
  givenname: William
  surname: Taylor
  fullname: Taylor, William
  organization: Inserm, U935, Université Paris Sud
– sequence: 3
  givenname: Xiao-Mei
  surname: Li
  fullname: Li, Xiao-Mei
  organization: Inserm, U935, Université Paris Sud, Université Paris Sud, Université Paris Saclay, UFR de Médecine Kremlin Bicêtre
– sequence: 4
  givenname: Yetki
  surname: Aslan
  fullname: Aslan, Yetki
  organization: Inserm, U1132, Université Paris Diderot, Hôpital Lariboisière - Centre Viggo Petersen
– sequence: 5
  givenname: Marthe
  surname: Villote
  fullname: Villote, Marthe
  organization: GABI, INRA, AgroParisTech, Université Paris-Saclay
– sequence: 6
  givenname: Julie
  surname: Rivière
  fullname: Rivière, Julie
  organization: GABI, INRA, AgroParisTech, Université Paris-Saclay
– sequence: 7
  givenname: Gaelle
  surname: Duvallet
  fullname: Duvallet, Gaelle
  organization: Inserm
– sequence: 8
  givenname: Charlotte
  surname: Auriau
  fullname: Auriau, Charlotte
  organization: Inserm
– sequence: 9
  givenname: Sandrine
  orcidid: 0000-0001-5529-0701
  surname: Dulong
  fullname: Dulong, Sandrine
  organization: Inserm, U935, Université Paris Sud, Université Paris Sud, Université Paris Saclay, UFR de Médecine Kremlin Bicêtre
– sequence: 10
  givenname: Isabelle
  orcidid: 0000-0002-8723-5472
  surname: Raymond-Letron
  fullname: Raymond-Letron, Isabelle
  organization: Département des Sciences Biologiques et Fonctionnelles, Laboratoire d’HistoPathologie Expérimentale et Comparée (LabHPEC), ENVT, Université de Toulouse, STROMALab, CNRS ERL5311, EFS, ENVT, Inserm U1031, Université de Toulouse
– sequence: 11
  givenname: Sylvain
  orcidid: 0000-0003-4087-4450
  surname: Provot
  fullname: Provot, Sylvain
  organization: Inserm, U1132, Université Paris Diderot, Hôpital Lariboisière - Centre Viggo Petersen
– sequence: 12
  givenname: Annelise
  surname: Bennaceur-Griscelli
  fullname: Bennaceur-Griscelli, Annelise
  organization: Inserm, U935, Université Paris Sud, Université Paris Sud, Université Paris Saclay, UFR de Médecine Kremlin Bicêtre, Service d’hématologie, APHP, GHU Paris Sud
– sequence: 13
  givenname: Hervé
  orcidid: 0000-0003-4761-1055
  surname: Acloque
  fullname: Acloque, Hervé
  email: herve.acloque@inra.fr
  organization: Inserm, U935, Université Paris Sud, GABI, INRA, AgroParisTech, Université Paris-Saclay
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32581213$$D View this record in MEDLINE/PubMed
https://inserm.hal.science/inserm-02907177$$DView record in HAL
BookMark eNp9ks1u1DAUhSNUREvpC7BAltiwIOC_xM4GqRoBrTQSG1hbjnMz41FsD7YzUt8eDymlnUW9iRN_59zrm_O6OvPBQ1W9JfgTwUx-TpzwVtSY4pq0ssN1-6K6oJiTmgjKzh7tz6urlHa4LNYRyfmr6pzRRhJK2EU1r7YxeGuQsdHowWqPBpvivM82eOTCME86Q0J9BJ0yMtobiChlcB5SQtoPyDo3e0DOmhjAH2zxc-AzygEN0R7KCeSi1ckmZP2RgzfVy1FPCa7un5fVr29ff65u6vWP77er63VtWs5yTWXbNL0URnBGhDEDjKLvMUjSCdxwaghuWM_HhgkmxChxZzRujaGDYZpTzi6r28V3CHqn9tE6He9U0Fb9_RDiRumYrZlAdawhtMEaA6N8BKG1YJhSzft-xHxoiteXxWs_9w4GU64Y9fTE9OmJt1u1CQclGOFCdsXg42KwPZHdXK-V9QmiU5h2WBAhDqTgH-7rxfB7hpSVs8nANGkPYU6KciKYbHErCvr-BN2FOfoy2SPVMlymIwv17vEFHlr4F4YC0AUoPzKlCOMDQrA6hk4toStdlvdj6FRbRPJEZGzWx_SUIdjpeSlbpKnU8RuI_9t-RvUHx2Xrug
CitedBy_id crossref_primary_10_1146_annurev_immunol_090122_050842
crossref_primary_10_3389_fgene_2022_834731
crossref_primary_10_1515_med_2022_0470
crossref_primary_10_1038_s41392_024_02108_4
crossref_primary_10_1016_j_neubiorev_2023_105383
crossref_primary_10_1016_j_cmet_2024_04_018
crossref_primary_10_1016_j_molmed_2023_09_003
crossref_primary_10_1016_j_bcp_2021_114482
crossref_primary_10_1093_sleep_zsad253
crossref_primary_10_1007_s00432_024_05917_w
crossref_primary_10_1080_08977194_2023_2227274
crossref_primary_10_1016_j_taap_2022_115863
crossref_primary_10_1111_jpi_12803
crossref_primary_10_1002_jcp_30815
crossref_primary_10_1111_imm_13647
crossref_primary_10_3390_ijms22147761
crossref_primary_10_1073_pnas_2401496121
crossref_primary_10_12688_f1000research_125272_1
crossref_primary_10_12688_f1000research_125272_2
crossref_primary_10_1016_j_ebiom_2024_105395
crossref_primary_10_1080_07853890_2023_2198256
crossref_primary_10_3389_fmolb_2024_1387576
crossref_primary_10_3390_biology11010021
crossref_primary_10_1016_j_tcb_2023_02_002
crossref_primary_10_1007_s10552_024_01951_8
crossref_primary_10_1172_JCI175706
crossref_primary_10_1007_s10555_022_10043_5
crossref_primary_10_3390_curroncol28010091
crossref_primary_10_1111_bph_15571
crossref_primary_10_1126_sciadv_aaz4530
crossref_primary_10_3389_fimmu_2024_1274474
crossref_primary_10_1152_ajpendo_00378_2023
crossref_primary_10_3390_cancers13112756
crossref_primary_10_14336_AD_2024_0327
crossref_primary_10_1016_j_heliyon_2023_e15986
crossref_primary_10_1016_j_gene_2021_145644
crossref_primary_10_1177_07487304211044301
crossref_primary_10_1007_s10735_024_10260_y
crossref_primary_10_1186_s12885_021_08854_w
crossref_primary_10_1016_j_bbcan_2022_188750
crossref_primary_10_1158_0008_5472_CAN_23_3942
crossref_primary_10_3389_fimmu_2022_776917
crossref_primary_10_1038_s41590_024_01859_0
crossref_primary_10_1016_j_isci_2023_106544
crossref_primary_10_3892_ijo_2021_5271
crossref_primary_10_1016_j_envint_2022_107256
crossref_primary_10_1093_bioinformatics_btac686
crossref_primary_10_1186_s13018_023_04442_9
crossref_primary_10_18632_aging_203596
crossref_primary_10_1016_j_heliyon_2024_e27356
crossref_primary_10_1038_s12276_021_00681_0
crossref_primary_10_1093_jb_mvac017
crossref_primary_10_3389_fcell_2021_739509
crossref_primary_10_1002_ctm2_755
crossref_primary_10_1080_07420528_2022_2072224
crossref_primary_10_1152_ajpcell_00122_2023
crossref_primary_10_1016_j_arres_2021_100018
crossref_primary_10_1016_j_bbcan_2022_188762
crossref_primary_10_1016_j_jrras_2024_100937
crossref_primary_10_1146_annurev_cancerbio_062822_122840
crossref_primary_10_1038_s41598_023_39401_1
crossref_primary_10_1016_j_mrrev_2022_108413
crossref_primary_10_3390_biology14010042
crossref_primary_10_3724_abbs_2025025
crossref_primary_10_1016_j_tcb_2021_06_008
crossref_primary_10_4049_jimmunol_2200516
crossref_primary_10_1007_s12038_024_00454_7
crossref_primary_10_1038_s41392_023_01337_3
crossref_primary_10_1016_j_scitotenv_2022_161161
crossref_primary_10_1126_sciadv_abo1123
crossref_primary_10_1016_j_bbih_2022_100428
crossref_primary_10_1038_s41590_024_01874_1
crossref_primary_10_1080_2162402X_2023_2255459
crossref_primary_10_3390_ijerph20053785
crossref_primary_10_12688_f1000research_128716_1
crossref_primary_10_1016_j_bbadis_2024_167549
crossref_primary_10_1016_j_jep_2025_119642
crossref_primary_10_1186_s12935_023_02926_6
crossref_primary_10_3390_ijms22010141
crossref_primary_10_12688_f1000research_128716_2
crossref_primary_10_3389_fimmu_2024_1444426
crossref_primary_10_1051_medsci_2021046
crossref_primary_10_1186_s13046_021_01919_5
crossref_primary_10_3389_fonc_2024_1436996
crossref_primary_10_1007_s00432_023_05094_2
crossref_primary_10_3390_ijms232214181
crossref_primary_10_1016_j_bbih_2022_100533
crossref_primary_10_1038_s41598_021_94478_w
crossref_primary_10_3390_ijms25115846
crossref_primary_10_3892_br_2021_1474
crossref_primary_10_1038_s43018_024_00759_4
crossref_primary_10_2139_ssrn_4120418
crossref_primary_10_2147_PGPM_S331431
crossref_primary_10_2147_OTT_S296373
crossref_primary_10_5334_jcr_203
crossref_primary_10_1038_s41392_022_00899_y
crossref_primary_10_1016_j_canlet_2024_217360
crossref_primary_10_1007_s00262_023_03495_3
crossref_primary_10_1038_s41377_021_00542_5
crossref_primary_10_1080_07853890_2025_2477304
crossref_primary_10_3389_fgene_2021_705512
crossref_primary_10_1016_j_smrv_2024_102031
crossref_primary_10_3389_fnmol_2023_1217992
crossref_primary_10_1186_s13059_020_02179_w
crossref_primary_10_1016_j_trecan_2023_11_002
crossref_primary_10_1073_pnas_2311854121
crossref_primary_10_1007_s10555_021_10010_6
crossref_primary_10_1007_s10555_022_10072_0
crossref_primary_10_3389_fmolb_2025_1540672
crossref_primary_10_1186_s12967_023_04699_y
crossref_primary_10_1111_apha_14027
crossref_primary_10_1016_j_critrevonc_2025_104632
crossref_primary_10_1371_journal_pone_0255296
crossref_primary_10_1007_s10928_021_09751_2
crossref_primary_10_1038_s41420_024_01960_1
crossref_primary_10_1007_s12035_023_03895_7
crossref_primary_10_1080_09291016_2021_1951470
crossref_primary_10_1016_j_bbcan_2021_188665
crossref_primary_10_1016_j_ebiom_2022_104121
crossref_primary_10_3389_fonc_2023_1284089
Cites_doi 10.1186/1471-2105-12-323
10.1016/j.cell.2008.03.027
10.1016/j.ccell.2016.04.014
10.1016/j.cell.2016.04.039
10.1016/j.cmet.2016.07.001
10.1007/s10654-018-0368-x
10.14814/phy2.12743
10.1200/JCO.2009.27.0215
10.1038/nri2506
10.1002/ijc.2910500323
10.1101/gad.242511.114
10.1182/blood-2017-04-778779
10.1073/pnas.0703900104
10.1158/0008-5472.CAN-04-0674
10.1186/s12885-016-2732-0
10.1038/nature04372
10.1038/s41467-019-12108-6
10.3322/caac.21492
10.1177/0748730411414264
10.1016/j.cub.2013.01.048
10.1371/journal.pone.0150606
10.1038/nature06685
10.3390/mps2040081
10.1371/journal.pone.0002888
10.1371/journal.pone.0017494
10.1126/science.1073776
10.1158/0008-5472.CAN-09-4235
10.1016/j.cmet.2015.06.005
10.1016/j.cell.2019.05.009
10.1242/dev.157966
10.1186/s12916-018-1010-1
10.1080/07420528.2018.1508151
10.1136/bmjopen-2016-012580
10.1002/bjs.10127
10.1073/pnas.1800695115
10.1042/BST0320792
10.1016/j.canlet.2011.04.018
10.1038/nm.3599
10.1210/en.2005-1343
10.1158/0008-5472.CAN-09-4672
10.1016/j.bbcan.2019.01.005
10.18632/oncotarget.16699
10.1371/journal.pcbi.1005752
10.1093/hmg/ddh173
10.1007/s40572-017-0155-y
10.1073/pnas.1720948115
10.1007/s11248-006-9056-9
10.3389/fonc.2018.00185
10.1038/nmeth.1923
10.1158/0008-5472.CAN-12-3989
10.1371/journal.pbio.0020377
10.1210/me.2012-1071
10.1016/j.cell.2012.04.042
10.1189/jlb.3RU1015-451R
10.3109/07420528.2013.782315
10.1080/2162402X.2017.1356965
10.1161/CIRCRESAHA.116.308034
10.1128/MCB.12.3.954
10.3892/or.2011.1207
10.1073/pnas.1815515116
10.1016/S0002-9440(10)63568-7
10.1530/REP-09-0523
10.4161/15384101.2014.954454
10.1074/jbc.M300609200
10.1016/j.humpath.2017.09.012
10.1038/35065016
10.1038/onc.2013.516
10.1016/S0092-8674(02)00961-3
10.1016/j.cell.2016.11.037
10.1093/jnci/93.20.1563
10.1016/j.bbrc.2015.08.059
10.1016/j.bbi.2012.07.019
10.1073/pnas.1222684110
10.1016/j.cell.2019.04.025
10.1038/s41577-018-0008-4
10.1093/bioinformatics/btw313
10.1073/pnas.0506580102
10.1016/S0168-9525(02)02794-4
10.1038/npjbcancer.2015.7
10.1016/j.ccr.2012.10.012
10.1038/nri.2017.49
10.1016/j.immuni.2018.10.007
10.1371/journal.pgen.1007135
10.1152/japplphysiol.00079.2011
10.1038/nature14897
10.1093/jnci/dji083
10.1111/j.1476-5381.2009.00182.x
10.1172/JCI38019
10.1093/nar/gki965
10.1016/j.neubiorev.2017.10.011
10.1016/j.cub.2015.06.012
10.1038/nature04496
10.1161/CIRCULATIONAHA.113.002885
10.1038/s41389-018-0117-8
10.1038/ncomms14287
10.1186/s13059-014-0550-8
10.1093/bioinformatics/btz700
10.1101/622050
ContentType Journal Article
Copyright The Author(s) 2020
The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Attribution
Copyright_xml – notice: The Author(s) 2020
– notice: The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Attribution
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
1XC
VOOES
5PM
DOA
DOI 10.1038/s41467-020-16890-6
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
Hyper Article en Ligne (HAL)
Hyper Article en Ligne (HAL) (Open Access)
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE



MEDLINE - Academic
Publicly Available Content Database
CrossRef
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 17
ExternalDocumentID oai_doaj_org_article_9351250a0e324fe7aa73022a4bbf04d5
PMC7314789
oai_HAL_inserm_02907177v1
32581213
10_1038_s41467_020_16890_6
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADMLS
ADRAZ
AENEX
AEUYN
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AASML
AAYXX
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AARCD
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
RC3
SOI
7X8
1XC
PMFND
VOOES
5PM
PUEGO
ID FETCH-LOGICAL-c643t-28655b87c74317ccdef7bb0e81970542c1053b4f537377f809ca06cc2dc3a4243
IEDL.DBID BENPR
ISSN 2041-1723
IngestDate Wed Aug 27 01:19:18 EDT 2025
Thu Aug 21 18:26:09 EDT 2025
Wed Jun 11 06:20:22 EDT 2025
Fri Jul 11 08:55:57 EDT 2025
Wed Aug 13 05:15:45 EDT 2025
Thu Apr 03 07:06:31 EDT 2025
Thu Apr 24 23:04:15 EDT 2025
Tue Jul 01 04:08:59 EDT 2025
Fri Feb 21 02:40:04 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Circadian rhythms
Breast cancer
Cancer stem cells
Cancer microenvironment
Language English
License Attribution: http://creativecommons.org/licenses/by
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c643t-28655b87c74317ccdef7bb0e81970542c1053b4f537377f809ca06cc2dc3a4243
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
PMCID: PMC7314789
ORCID 0000-0003-4087-4450
0000-0001-5529-0701
0000-0003-4761-1055
0000-0002-8723-5472
0000-0002-5253-814X
0000-0002-0836-7814
0000-0002-9411-9605
OpenAccessLink https://www.proquest.com/docview/2416303778?pq-origsite=%requestingapplication%
PMID 32581213
PQID 2416303778
PQPubID 546298
PageCount 17
ParticipantIDs doaj_primary_oai_doaj_org_article_9351250a0e324fe7aa73022a4bbf04d5
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7314789
hal_primary_oai_HAL_inserm_02907177v1
proquest_miscellaneous_2417386067
proquest_journals_2416303778
pubmed_primary_32581213
crossref_primary_10_1038_s41467_020_16890_6
crossref_citationtrail_10_1038_s41467_020_16890_6
springer_journals_10_1038_s41467_020_16890_6
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2020-06-24
PublicationDateYYYYMMDD 2020-06-24
PublicationDate_xml – month: 06
  year: 2020
  text: 2020-06-24
  day: 24
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2020
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Mocellin, Tropea, Benna, Rossi (CR7) 2018; 16
Love, Huber, Anders (CR96) 2014; 15
Yang (CR12) 2017; 8
Wang, Lee, Malbon (CR65) 2004; 32
Langmead, Salzberg (CR92) 2012; 9
Papagiannakopoulos (CR59) 2016; 24
Müller (CR41) 2001; 410
Paine, Soule, Pauley, Dawson (CR89) 1992; 50
Visvader, Stingl (CR26) 2014; 28
Vandewalle (CR70) 2005; 33
Hwang-Verslues (CR13) 2013; 110
Oike, Sakurai, Ippoushi, Kobori (CR18) 2015; 465
Filipski (CR57) 2005; 97
Mao (CR68) 2012; 26
Shackleton (CR24) 2006; 439
Zhao (CR77) 2017; 130
Pluquet (CR79) 2013; 73
Shi, Ansari, McGuinness, Wasserman, Johnson (CR52) 2013; 23
Davie (CR16) 2007; 16
Wang, Shen, Siegal, Wei (CR32) 2017; 69
CR46
Gabrilovich, Nagaraj (CR36) 2009; 9
Bray (CR1) 2018; 68
Acharyya (CR44) 2012; 150
Hansen (CR4) 2017; 4
Pan, Jiang, Hussain (CR50) 2013; 128
Oshima (CR61) 2011; 25
Tagliabue (CR2) 2016; 6
Bradley, Bond, Manini, Brown, Charlton (CR43) 2009; 158
Koronowski (CR67) 2019; 177
Romero-Moreno (CR84) 2019; 10
Carter (CR75) 2016; 99
Mani (CR71) 2007; 104
Feng (CR82) 2018; 115
Halpern, Kilbarger, Lynch (CR39) 2011; 308
Sephton (CR45) 2013; 30
Sukumaran, Jusko, DuBois, Almon (CR78) 2011; 110
Masri (CR56) 2016; 165
Hadadi, Souza, de, Bennaceur-Griscelli, Acloque (CR29) 2018; 35
Welz (CR66) 2019; 177
Kettner (CR53) 2015; 22
Méndez-Ferrer, Lucas, Battista, Frenette (CR85) 2008; 452
Subramanian (CR98) 2005; 102
He (CR35) 2018; 49
Rudic (CR54) 2004; 2
Lin (CR20) 2003; 163
Michaeli (CR81) 2017; 6
McQueen (CR9) 2018; 145
Movahedi (CR31) 2010; 70
Hollern, Swiatnicki, Andrechek (CR48) 2018; 14
Shou, Zhang, Lai, Chen, Huang (CR34) 2016; 16
Scheiermann, Gibbs, Ince, Loudon (CR76) 2018; 18
Guy, Cardiff, Muller (CR15) 1992; 12
Boden, Varcoe, Voultsios, Kennaway (CR10) 2010; 139
Cordina-Duverger (CR6) 2018; 33
Nagarsheth, Wicha, Zou (CR86) 2017; 17
Helbig (CR42) 2003; 278
Mani (CR21) 2008; 133
Peranzoni (CR83) 2018; 115
de Assis (CR88) 2018; 8
Ye (CR47) 2015; 525
Cermakian (CR74) 2013; 30
Morel (CR22) 2008; 3
Filipski (CR17) 2004; 64
Van Dycke (CR14) 2015; 25
Fu, Pelicano, Liu, Huang, Lee (CR28) 2002; 111
Cheng, Ma, Wei, Wei (CR80) 2019; 1871
Casiraghi, Alzamendi, Giovambattista, Chiesa, Golombek (CR19) 2016; 4
Gibbs (CR40) 2014; 20
Bashir, Damineni, Mukherjee, Kondaiah (CR72) 2015; 1
Federico, Monti (CR97) 2020; 36
Mollema (CR63) 2011; 6
Hoshino, Wakatsuki, Iigo, Shibata (CR11) 2006; 147
Chen (CR87) 2019; 116
Sano (CR38) 2019; 8
Yu (CR30) 2016; 11
Steele (CR37) 2016; 29
Hojo (CR55) 2017; 8
Cadenas (CR8) 2014; 13
Asano (CR33) 2016; 103
Lambert, Pattabiraman, Weinberg (CR69) 2017; 168
Acloque, Adams, Fishwick, Bronner-Fraser, Nieto (CR23) 2009; 119
Samuelsson, Bovbjerg, Roecklein, Hall (CR5) 2018; 84
Vassilopoulos, Chisholm, Lahusen, Zheng, Deng (CR27) 2014; 33
Li, Dewey (CR93) 2011; 12
Cheng (CR62) 2004; 13
McAlpine, Swirski (CR51) 2016; 119
Delaunay, Laudet (CR49) 2002; 18
Li (CR58) 2010; 70
Climent (CR60) 2010; 28
Rohart, Gautier, Singh, Lê Cao (CR95) 2017; 13
Ocaña (CR73) 2012; 22
Gu, Eils, Schlesner (CR94) 2016; 32
Stingl (CR25) 2006; 439
Ahumada (CR64) 2002; 298
Schernhammer (CR3) 2001; 93
Schmid, Helfrich-Förster, Yoshii (CR91) 2011; 26
Oike, Ogawa, Oishi (CR90) 2019; 2
16890_CR46
S Mocellin (16890_CR7) 2018; 16
A-P Morel (16890_CR22) 2008; 3
J Shou (16890_CR34) 2016; 16
C Vandewalle (16890_CR70) 2005; 33
MI Love (16890_CR96) 2014; 15
N Yang (16890_CR12) 2017; 8
Y Zhao (16890_CR77) 2017; 130
MJ Boden (16890_CR10) 2010; 139
M Sano (16890_CR38) 2019; 8
LVM de Assis (16890_CR88) 2018; 8
E Filipski (16890_CR17) 2004; 64
J Gibbs (16890_CR40) 2014; 20
P-S Welz (16890_CR66) 2019; 177
CM McQueen (16890_CR9) 2018; 145
OH Ocaña (16890_CR73) 2012; 22
NJ Mollema (16890_CR63) 2011; 6
IX Chen (16890_CR87) 2019; 116
G Tagliabue (16890_CR2) 2016; 6
JE Visvader (16890_CR26) 2014; 28
N Cermakian (16890_CR74) 2013; 30
H Wang (16890_CR65) 2004; 32
S Masri (16890_CR56) 2016; 165
SA Mani (16890_CR71) 2007; 104
S Sukumaran (16890_CR78) 2011; 110
L Fu (16890_CR28) 2002; 111
AW Lambert (16890_CR69) 2017; 168
Y-RA Yu (16890_CR30) 2016; 11
F Rohart (16890_CR95) 2017; 13
W He (16890_CR35) 2018; 49
KCG Van Dycke (16890_CR14) 2015; 25
X Pan (16890_CR50) 2013; 128
S Méndez-Ferrer (16890_CR85) 2008; 452
B Schmid (16890_CR91) 2011; 26
E Hadadi (16890_CR29) 2018; 35
A Federico (16890_CR97) 2020; 36
J Hansen (16890_CR4) 2017; 4
Z Gu (16890_CR94) 2016; 32
DP Hollern (16890_CR48) 2018; 14
J Michaeli (16890_CR81) 2017; 6
J Climent (16890_CR60) 2010; 28
CW Steele (16890_CR37) 2016; 29
Y Cheng (16890_CR80) 2019; 1871
H Hojo (16890_CR55) 2017; 8
XM Li (16890_CR58) 2010; 70
A Subramanian (16890_CR98) 2005; 102
F Bray (16890_CR1) 2018; 68
KB Koronowski (16890_CR67) 2019; 177
A Ahumada (16890_CR64) 2002; 298
WW Hwang-Verslues (16890_CR13) 2013; 110
SA Davie (16890_CR16) 2007; 16
JL Halpern (16890_CR39) 2011; 308
RD Rudic (16890_CR54) 2004; 2
H Cheng (16890_CR62) 2004; 13
K Wang (16890_CR32) 2017; 69
E Filipski (16890_CR57) 2005; 97
J Stingl (16890_CR25) 2006; 439
B Langmead (16890_CR92) 2012; 9
K Hoshino (16890_CR11) 2006; 147
S Acharyya (16890_CR44) 2012; 150
B Li (16890_CR93) 2011; 12
CS McAlpine (16890_CR51) 2016; 119
C Cadenas (16890_CR8) 2014; 13
Y Asano (16890_CR33) 2016; 103
T Oshima (16890_CR61) 2011; 25
M Bradley (16890_CR43) 2009; 158
L Mao (16890_CR68) 2012; 26
E Cordina-Duverger (16890_CR6) 2018; 33
F Delaunay (16890_CR49) 2002; 18
M Bashir (16890_CR72) 2015; 1
C Scheiermann (16890_CR76) 2018; 18
G Helbig (16890_CR42) 2003; 278
A Müller (16890_CR41) 2001; 410
N Nagarsheth (16890_CR86) 2017; 17
LB Samuelsson (16890_CR5) 2018; 84
S Feng (16890_CR82) 2018; 115
R Romero-Moreno (16890_CR84) 2019; 10
H Acloque (16890_CR23) 2009; 119
H Oike (16890_CR90) 2019; 2
CT Guy (16890_CR15) 1992; 12
EY Lin (16890_CR20) 2003; 163
K Movahedi (16890_CR31) 2010; 70
LP Casiraghi (16890_CR19) 2016; 4
H Oike (16890_CR18) 2015; 465
DI Gabrilovich (16890_CR36) 2009; 9
TM Paine (16890_CR89) 1992; 50
SA Mani (16890_CR21) 2008; 133
E Peranzoni (16890_CR83) 2018; 115
M Shackleton (16890_CR24) 2006; 439
A Vassilopoulos (16890_CR27) 2014; 33
SE Sephton (16890_CR45) 2013; 30
T Papagiannakopoulos (16890_CR59) 2016; 24
X Ye (16890_CR47) 2015; 525
S Shi (16890_CR52) 2013; 23
O Pluquet (16890_CR79) 2013; 73
ES Schernhammer (16890_CR3) 2001; 93
SJ Carter (16890_CR75) 2016; 99
NM Kettner (16890_CR53) 2015; 22
References_xml – volume: 12
  year: 2011
  ident: CR93
  article-title: RSEM: accurate transcript quantification from RNA-seq data with or without a reference genome
  publication-title: BMC Bioinforma.
  doi: 10.1186/1471-2105-12-323
– volume: 133
  start-page: 704
  year: 2008
  end-page: 715
  ident: CR21
  article-title: The epithelial-mesenchymal transition generates cells with properties of stem cells
  publication-title: Cell
  doi: 10.1016/j.cell.2008.03.027
– volume: 29
  start-page: 832
  year: 2016
  end-page: 845
  ident: CR37
  article-title: CXCR2 inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2016.04.014
– volume: 165
  start-page: 896
  year: 2016
  end-page: 909
  ident: CR56
  article-title: Lung adenocarcinoma distally rewires hepatic circadian homeostasis
  publication-title: Cell
  doi: 10.1016/j.cell.2016.04.039
– volume: 24
  start-page: 324
  year: 2016
  end-page: 331
  ident: CR59
  article-title: Circadian rhythm disruption promotes lung tumorigenesis
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2016.07.001
– volume: 33
  start-page: 369
  year: 2018
  end-page: 379
  ident: CR6
  article-title: Night shift work and breast cancer: a pooled analysis of population-based case–control studies with complete work history
  publication-title: Eur. J. Epidemiol.
  doi: 10.1007/s10654-018-0368-x
– volume: 4
  start-page: e12743
  year: 2016
  ident: CR19
  article-title: Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice
  publication-title: Physiol. Rep.
  doi: 10.14814/phy2.12743
– volume: 28
  start-page: 3770
  year: 2010
  end-page: 3778
  ident: CR60
  article-title: Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2009.27.0215
– volume: 9
  start-page: 162
  year: 2009
  end-page: 174
  ident: CR36
  article-title: Myeloid-derived suppressor cells as regulators of the immune system
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri2506
– volume: 50
  start-page: 463
  year: 1992
  end-page: 473
  ident: CR89
  article-title: Characterization of epithelial phenotypes in mortal and immortal human breast cells
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.2910500323
– volume: 28
  start-page: 1143
  year: 2014
  end-page: 1158
  ident: CR26
  article-title: Mammary stem cells and the differentiation hierarchy: current status and perspectives
  publication-title: Genes Dev.
  doi: 10.1101/gad.242511.114
– volume: 130
  start-page: 1995
  year: 2017
  end-page: 2005
  ident: CR77
  article-title: Uncovering the mystery of opposite circadian rhythms between mouse and human leukocytes in humanized mice
  publication-title: Blood
  doi: 10.1182/blood-2017-04-778779
– volume: 104
  start-page: 10069
  year: 2007
  end-page: 10074
  ident: CR71
  article-title: Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0703900104
– volume: 64
  start-page: 7879
  year: 2004
  end-page: 7885
  ident: CR17
  article-title: Effects of chronic jet lag on tumor progression in mice
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-04-0674
– volume: 16
  year: 2016
  ident: CR34
  article-title: Worse outcome in breast cancer with higher tumor-infiltrating FOXP3+ Tregs: a systematic review and meta-analysis
  publication-title: BMC Cancer
  doi: 10.1186/s12885-016-2732-0
– volume: 439
  start-page: 84
  year: 2006
  end-page: 88
  ident: CR24
  article-title: Generation of a functional mammary gland from a single stem cell
  publication-title: Nature
  doi: 10.1038/nature04372
– volume: 10
  year: 2019
  ident: CR84
  article-title: The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-12108-6
– volume: 68
  start-page: 394
  year: 2018
  end-page: 424
  ident: CR1
  article-title: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
  publication-title: Ca. Cancer J. Clin.
  doi: 10.3322/caac.21492
– volume: 26
  start-page: 464
  year: 2011
  end-page: 467
  ident: CR91
  article-title: A new ImageJ plug-in “ActogramJ” for chronobiological analyses
  publication-title: J. Biol. Rhythms
  doi: 10.1177/0748730411414264
– volume: 23
  start-page: 372
  year: 2013
  end-page: 381
  ident: CR52
  article-title: Circadian disruption leads to insulin resistance and obesity
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2013.01.048
– volume: 11
  start-page: e0150606
  year: 2016
  ident: CR30
  article-title: A protocol for the comprehensive flow cytometric analysis of immune cells in normal and inflamed murine non-lymphoid tissues
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0150606
– volume: 452
  start-page: 442
  year: 2008
  end-page: 447
  ident: CR85
  article-title: Haematopoietic stem cell release is regulated by circadian oscillations
  publication-title: Nature
  doi: 10.1038/nature06685
– volume: 2
  start-page: 81
  year: 2019
  ident: CR90
  article-title: Simple and quick visualization of periodical data using microsoft excel
  publication-title: Methods Protoc.
  doi: 10.3390/mps2040081
– volume: 3
  start-page: e2888
  year: 2008
  ident: CR22
  article-title: Generation of breast cancer stem cells through epithelial-mesenchymal transition
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0002888
– volume: 6
  start-page: e17494
  year: 2011
  ident: CR63
  article-title: Nuclear receptor rev-erb alpha ( ) functions in concert with to regulate transcriptional networks in the retina
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0017494
– volume: 298
  start-page: 2006
  year: 2002
  end-page: 2010
  ident: CR64
  article-title: Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP
  publication-title: Science
  doi: 10.1126/science.1073776
– volume: 70
  start-page: 3351
  year: 2010
  end-page: 3360
  ident: CR58
  article-title: Cancer inhibition through circadian reprogramming of tumor transcriptome with meal timing
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-09-4235
– volume: 22
  start-page: 448
  year: 2015
  end-page: 459
  ident: CR53
  article-title: Circadian dysfunction induces leptin resistance in mice
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2015.06.005
– volume: 177
  start-page: 1436
  year: 2019
  end-page: 1447.e12
  ident: CR66
  article-title: BMAL1-driven tissue clocks respond independently to light to maintain homeostasis
  publication-title: Cell
  doi: 10.1016/j.cell.2019.05.009
– volume: 145
  start-page: dev157966
  year: 2018
  ident: CR9
  article-title: PER2 regulation of mammary gland development
  publication-title: Development
  doi: 10.1242/dev.157966
– volume: 16
  year: 2018
  ident: CR7
  article-title: Circadian pathway genetic variation and cancer risk: evidence from genome-wide association studies
  publication-title: BMC Med.
  doi: 10.1186/s12916-018-1010-1
– volume: 36
  start-page: 1307
  year: 2020
  end-page: 1308
  ident: CR97
  article-title: hypeR: an R package for geneset enrichment workflows
  publication-title: Bioinformatics
– volume: 35
  start-page: 1689
  year: 2018
  end-page: 1701
  ident: CR29
  article-title: Identification of valid reference genes for circadian gene-expression studies in human mammary epithelial cells
  publication-title: Chronobiol. Int.
  doi: 10.1080/07420528.2018.1508151
– volume: 6
  start-page: e012580
  year: 2016
  ident: CR2
  article-title: Atmospheric fine particulate matter and breast cancer mortality: a population-based cohort study
  publication-title: BMJ Open
  doi: 10.1136/bmjopen-2016-012580
– volume: 103
  start-page: 845
  year: 2016
  end-page: 854
  ident: CR33
  article-title: Tumour-infiltrating CD8 to FOXP3 lymphocyte ratio in predicting treatment responses to neoadjuvant chemotherapy of aggressive breast cancer: tumour-infiltrating lymphocytes as predictors of response to chemotherapy in breast cancer
  publication-title: Br. J. Surg.
  doi: 10.1002/bjs.10127
– volume: 115
  start-page: 10094
  year: 2018
  end-page: 10099
  ident: CR82
  article-title: Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1800695115
– volume: 32
  start-page: 792
  year: 2004
  end-page: 796
  ident: CR65
  article-title: PDE6 is an effector for the Wnt/Ca /cGMP-signalling pathway in development
  publication-title: Biochem. Soc. Trans.
  doi: 10.1042/BST0320792
– volume: 308
  start-page: 91
  year: 2011
  end-page: 99
  ident: CR39
  article-title: Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2011.04.018
– volume: 20
  start-page: 919
  year: 2014
  end-page: 926
  ident: CR40
  article-title: An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action
  publication-title: Nat. Med.
  doi: 10.1038/nm.3599
– volume: 147
  start-page: 1916
  year: 2006
  end-page: 1923
  ident: CR11
  article-title: Circadian clock mutation in dams disrupts nursing behavior and growth of pups
  publication-title: Endocrinology
  doi: 10.1210/en.2005-1343
– volume: 70
  start-page: 5728
  year: 2010
  end-page: 5739
  ident: CR31
  article-title: Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-09-4672
– volume: 1871
  start-page: 289
  year: 2019
  end-page: 312
  ident: CR80
  article-title: Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases
  publication-title: Biochim. Biophys. Acta BBA - Rev. Cancer
  doi: 10.1016/j.bbcan.2019.01.005
– volume: 8
  start-page: 34128
  year: 2017
  end-page: 34140
  ident: CR55
  article-title: Remote reprogramming of hepatic circadian transcriptome by breast cancer
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.16699
– volume: 13
  start-page: e1005752
  year: 2017
  ident: CR95
  article-title: mixOmics: an R package for ‘omics feature selection and multiple data integration
  publication-title: PLoS Comput. Biol.
  doi: 10.1371/journal.pcbi.1005752
– volume: 13
  start-page: 1563
  year: 2004
  end-page: 1575
  ident: CR62
  article-title: Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddh173
– volume: 4
  start-page: 325
  year: 2017
  end-page: 339
  ident: CR4
  article-title: Night shift work and risk of breast cancer
  publication-title: Curr. Environ. Health Rep.
  doi: 10.1007/s40572-017-0155-y
– volume: 115
  start-page: E4041
  year: 2018
  end-page: E4050
  ident: CR83
  article-title: Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1720948115
– volume: 16
  start-page: 193
  year: 2007
  end-page: 201
  ident: CR16
  article-title: Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient mice
  publication-title: Transgenic Res.
  doi: 10.1007/s11248-006-9056-9
– volume: 8
  start-page: 185
  year: 2018
  ident: CR88
  article-title: Expression of the circadian clock gene BMAL1 positively correlates with antitumor immunity and patient survival in metastatic melanoma
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2018.00185
– volume: 9
  start-page: 357
  year: 2012
  end-page: 359
  ident: CR92
  article-title: Fast gapped-read alignment with Bowtie 2
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1923
– volume: 73
  start-page: 4732
  year: 2013
  end-page: 4743
  ident: CR79
  article-title: Posttranscriptional regulation of PER1 underlies the oncogenic function of IRE
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-12-3989
– volume: 2
  start-page: e377
  year: 2004
  ident: CR54
  article-title: BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.0020377
– volume: 26
  start-page: 1808
  year: 2012
  end-page: 1820
  ident: CR68
  article-title: Circadian gating of epithelial-to-mesenchymal transition in breast cancer cells via melatonin-regulation of GSK3β
  publication-title: Mol. Endocrinol.
  doi: 10.1210/me.2012-1071
– volume: 150
  start-page: 165
  year: 2012
  end-page: 178
  ident: CR44
  article-title: A CXCL1 paracrine network links cancer chemoresistance and metastasis
  publication-title: Cell
  doi: 10.1016/j.cell.2012.04.042
– volume: 99
  start-page: 549
  year: 2016
  end-page: 560
  ident: CR75
  article-title: A matter of time: study of circadian clocks and their role in inflammation
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.3RU1015-451R
– volume: 30
  start-page: 870
  year: 2013
  end-page: 888
  ident: CR74
  article-title: Crosstalk between the circadian clock circuitry and the immune system
  publication-title: Chronobiol. Int.
  doi: 10.3109/07420528.2013.782315
– volume: 6
  start-page: e1356965
  year: 2017
  ident: CR81
  article-title: Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment
  publication-title: OncoImmunology
  doi: 10.1080/2162402X.2017.1356965
– volume: 119
  start-page: 131
  year: 2016
  end-page: 141
  ident: CR51
  article-title: Circadian influence on metabolism and inflammation in atherosclerosis
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.116.308034
– volume: 12
  start-page: 954
  year: 1992
  end-page: 961
  ident: CR15
  article-title: Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.12.3.954
– volume: 25
  start-page: 1439
  year: 2011
  end-page: 1446
  ident: CR61
  article-title: Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2011.1207
– ident: CR46
– volume: 116
  start-page: 4558
  year: 2019
  end-page: 4566
  ident: CR87
  article-title: Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1815515116
– volume: 163
  start-page: 2113
  year: 2003
  end-page: 2126
  ident: CR20
  article-title: Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases
  publication-title: Am. J. Pathol.
  doi: 10.1016/S0002-9440(10)63568-7
– volume: 139
  start-page: 1077
  year: 2010
  end-page: 1090
  ident: CR10
  article-title: Reproductive biology of female Bmal1 null mice
  publication-title: Reproduction
  doi: 10.1530/REP-09-0523
– volume: 13
  start-page: 3282
  year: 2014
  end-page: 3291
  ident: CR8
  article-title: Loss of circadian clock gene expression is associated with tumor progression in breast cancer
  publication-title: Cell Cycle
  doi: 10.4161/15384101.2014.954454
– volume: 278
  start-page: 21631
  year: 2003
  end-page: 21638
  ident: CR42
  article-title: NF-κB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M300609200
– volume: 69
  start-page: 110
  year: 2017
  end-page: 117
  ident: CR32
  article-title: The CD4/CD8 ratio of tumor-infiltrating lymphocytes at the tumor-host interface has prognostic value in triple-negative breast cancer
  publication-title: Hum. Pathol.
  doi: 10.1016/j.humpath.2017.09.012
– volume: 410
  start-page: 50
  year: 2001
  end-page: 56
  ident: CR41
  article-title: Involvement of chemokine receptors in breast cancer metastasis
  publication-title: Nature
  doi: 10.1038/35065016
– volume: 33
  start-page: 5477
  year: 2014
  end-page: 5482
  ident: CR27
  article-title: A critical role of CD29 and CD49f in mediating metastasis for cancer-initiating cells isolated from a Brca1-associated mouse model of breast cancer
  publication-title: Oncogene
  doi: 10.1038/onc.2013.516
– volume: 111
  start-page: 41
  year: 2002
  end-page: 50
  ident: CR28
  article-title: The circadian gene period2 plays an important role in tumor suppression and DNA damage response in vivo
  publication-title: Cell
  doi: 10.1016/S0092-8674(02)00961-3
– volume: 168
  start-page: 670
  year: 2017
  end-page: 691
  ident: CR69
  article-title: Emerging biological principles of metastasis
  publication-title: Cell
  doi: 10.1016/j.cell.2016.11.037
– volume: 93
  start-page: 1563
  year: 2001
  end-page: 1568
  ident: CR3
  article-title: Rotating night shifts and risk of breast cancer in women participating in the nurses’ health study
  publication-title: JNCI J. Natl Cancer Inst.
  doi: 10.1093/jnci/93.20.1563
– volume: 465
  start-page: 556
  year: 2015
  end-page: 561
  ident: CR18
  article-title: Time-fixed feeding prevents obesity induced by chronic advances of light/dark cycles in mouse models of jet-lag/shift work
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2015.08.059
– volume: 30
  start-page: S163
  year: 2013
  end-page: S170
  ident: CR45
  article-title: Diurnal cortisol rhythm as a predictor of lung cancer survival
  publication-title: Brain. Behav. Immun.
  doi: 10.1016/j.bbi.2012.07.019
– volume: 110
  start-page: 12331
  year: 2013
  end-page: 12336
  ident: CR13
  article-title: Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1222684110
– volume: 177
  start-page: 1448
  year: 2019
  end-page: 1462.e14
  ident: CR67
  article-title: Defining the independence of the liver circadian clock
  publication-title: Cell
  doi: 10.1016/j.cell.2019.04.025
– volume: 18
  start-page: 423
  year: 2018
  end-page: 437
  ident: CR76
  article-title: Clocking in to immunity
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-018-0008-4
– volume: 32
  start-page: 2847
  year: 2016
  end-page: 2849
  ident: CR94
  article-title: Complex heatmaps reveal patterns and correlations in multidimensional genomic data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btw313
– volume: 102
  start-page: 15545
  year: 2005
  end-page: 15550
  ident: CR98
  article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0506580102
– volume: 18
  start-page: 595
  year: 2002
  end-page: 597
  ident: CR49
  article-title: Circadian clock and microarrays: mammalian genome gets rhythm
  publication-title: Trends Genet.
  doi: 10.1016/S0168-9525(02)02794-4
– volume: 1
  year: 2015
  ident: CR72
  article-title: Activin-A signaling promotes epithelial–mesenchymal transition, invasion, and metastatic growth of breast cancer
  publication-title: Npj Breast Cancer
  doi: 10.1038/npjbcancer.2015.7
– volume: 22
  start-page: 709
  year: 2012
  end-page: 724
  ident: CR73
  article-title: Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.10.012
– volume: 17
  start-page: 559
  year: 2017
  end-page: 572
  ident: CR86
  article-title: Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri.2017.49
– volume: 49
  start-page: 1175
  year: 2018
  end-page: 1190.e7
  ident: CR35
  article-title: Circadian expression of migratory factors establishes lineage-specific signatures that guide the homing of leukocyte subsets to tissues
  publication-title: Immunity
  doi: 10.1016/j.immuni.2018.10.007
– volume: 14
  start-page: e1007135
  year: 2018
  ident: CR48
  article-title: Histological subtypes of mouse mammary tumors reveal conserved relationships to human cancers
  publication-title: PLOS Genet.
  doi: 10.1371/journal.pgen.1007135
– volume: 110
  start-page: 1732
  year: 2011
  end-page: 1747
  ident: CR78
  article-title: Light-dark oscillations in the lung transcriptome: implications for lung homeostasis, repair, metabolism, disease, and drug action
  publication-title: J. Appl. Physiol.
  doi: 10.1152/japplphysiol.00079.2011
– volume: 525
  start-page: 256
  year: 2015
  end-page: 260
  ident: CR47
  article-title: Distinct EMT programs control normal mammary stem cells and tumour-initiating cells
  publication-title: Nature
  doi: 10.1038/nature14897
– volume: 97
  start-page: 507
  year: 2005
  end-page: 517
  ident: CR57
  article-title: Effects of light and food schedules on liver and tumor molecular clocks in mice
  publication-title: JNCI J. Natl Cancer Inst.
  doi: 10.1093/jnci/dji083
– volume: 158
  start-page: 328
  year: 2009
  end-page: 338
  ident: CR43
  article-title: SB265610 is an allosteric, inverse agonist at the human CXCR2 receptor
  publication-title: Br. J. Pharm.
  doi: 10.1111/j.1476-5381.2009.00182.x
– volume: 119
  start-page: 1438
  year: 2009
  end-page: 1449
  ident: CR23
  article-title: Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI38019
– volume: 33
  start-page: 6566
  year: 2005
  end-page: 6578
  ident: CR70
  article-title: SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gki965
– volume: 84
  start-page: 35
  year: 2018
  end-page: 48
  ident: CR5
  article-title: Sleep and circadian disruption and incident breast cancer risk: An evidence-based and theoretical review
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2017.10.011
– volume: 25
  start-page: 1932
  year: 2015
  end-page: 1937
  ident: CR14
  article-title: Chronically alternating light cycles increase breast cancer risk in mice
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2015.06.012
– volume: 439
  start-page: 993
  year: 2006
  end-page: 997
  ident: CR25
  article-title: Purification and unique properties of mammary epithelial stem cells
  publication-title: Nature
  doi: 10.1038/nature04496
– volume: 128
  start-page: 1758
  year: 2013
  end-page: 1769
  ident: CR50
  article-title: Impaired cholesterol metabolism and enhanced atherosclerosis in clock mutant mice
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.113.002885
– volume: 8
  year: 2019
  ident: CR38
  article-title: Blocking CXCLs–CXCR2 axis in tumor–stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment
  publication-title: Oncogenesis
  doi: 10.1038/s41389-018-0117-8
– volume: 8
  year: 2017
  ident: CR12
  article-title: Cellular mechano-environment regulates the mammary circadian clock
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms14287
– volume: 15
  year: 2014
  ident: CR96
  article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
– volume: 15
  year: 2014
  ident: 16890_CR96
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
– volume: 439
  start-page: 993
  year: 2006
  ident: 16890_CR25
  publication-title: Nature
  doi: 10.1038/nature04496
– volume: 9
  start-page: 162
  year: 2009
  ident: 16890_CR36
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri2506
– volume: 6
  start-page: e17494
  year: 2011
  ident: 16890_CR63
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0017494
– volume: 32
  start-page: 2847
  year: 2016
  ident: 16890_CR94
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btw313
– volume: 18
  start-page: 595
  year: 2002
  ident: 16890_CR49
  publication-title: Trends Genet.
  doi: 10.1016/S0168-9525(02)02794-4
– volume: 163
  start-page: 2113
  year: 2003
  ident: 16890_CR20
  publication-title: Am. J. Pathol.
  doi: 10.1016/S0002-9440(10)63568-7
– volume: 298
  start-page: 2006
  year: 2002
  ident: 16890_CR64
  publication-title: Science
  doi: 10.1126/science.1073776
– volume: 73
  start-page: 4732
  year: 2013
  ident: 16890_CR79
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-12-3989
– volume: 20
  start-page: 919
  year: 2014
  ident: 16890_CR40
  publication-title: Nat. Med.
  doi: 10.1038/nm.3599
– volume: 17
  start-page: 559
  year: 2017
  ident: 16890_CR86
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri.2017.49
– volume: 165
  start-page: 896
  year: 2016
  ident: 16890_CR56
  publication-title: Cell
  doi: 10.1016/j.cell.2016.04.039
– volume: 158
  start-page: 328
  year: 2009
  ident: 16890_CR43
  publication-title: Br. J. Pharm.
  doi: 10.1111/j.1476-5381.2009.00182.x
– volume: 18
  start-page: 423
  year: 2018
  ident: 16890_CR76
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-018-0008-4
– volume: 29
  start-page: 832
  year: 2016
  ident: 16890_CR37
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2016.04.014
– volume: 25
  start-page: 1439
  year: 2011
  ident: 16890_CR61
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2011.1207
– volume: 8
  year: 2017
  ident: 16890_CR12
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms14287
– volume: 14
  start-page: e1007135
  year: 2018
  ident: 16890_CR48
  publication-title: PLOS Genet.
  doi: 10.1371/journal.pgen.1007135
– volume: 64
  start-page: 7879
  year: 2004
  ident: 16890_CR17
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-04-0674
– volume: 2
  start-page: 81
  year: 2019
  ident: 16890_CR90
  publication-title: Methods Protoc.
  doi: 10.3390/mps2040081
– volume: 103
  start-page: 845
  year: 2016
  ident: 16890_CR33
  publication-title: Br. J. Surg.
  doi: 10.1002/bjs.10127
– volume: 99
  start-page: 549
  year: 2016
  ident: 16890_CR75
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.3RU1015-451R
– volume: 145
  start-page: dev157966
  year: 2018
  ident: 16890_CR9
  publication-title: Development
  doi: 10.1242/dev.157966
– volume: 133
  start-page: 704
  year: 2008
  ident: 16890_CR21
  publication-title: Cell
  doi: 10.1016/j.cell.2008.03.027
– volume: 12
  year: 2011
  ident: 16890_CR93
  publication-title: BMC Bioinforma.
  doi: 10.1186/1471-2105-12-323
– volume: 177
  start-page: 1448
  year: 2019
  ident: 16890_CR67
  publication-title: Cell
  doi: 10.1016/j.cell.2019.04.025
– volume: 1871
  start-page: 289
  year: 2019
  ident: 16890_CR80
  publication-title: Biochim. Biophys. Acta BBA - Rev. Cancer
  doi: 10.1016/j.bbcan.2019.01.005
– volume: 70
  start-page: 5728
  year: 2010
  ident: 16890_CR31
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-09-4672
– volume: 168
  start-page: 670
  year: 2017
  ident: 16890_CR69
  publication-title: Cell
  doi: 10.1016/j.cell.2016.11.037
– volume: 33
  start-page: 5477
  year: 2014
  ident: 16890_CR27
  publication-title: Oncogene
  doi: 10.1038/onc.2013.516
– volume: 28
  start-page: 1143
  year: 2014
  ident: 16890_CR26
  publication-title: Genes Dev.
  doi: 10.1101/gad.242511.114
– volume: 119
  start-page: 1438
  year: 2009
  ident: 16890_CR23
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI38019
– volume: 23
  start-page: 372
  year: 2013
  ident: 16890_CR52
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2013.01.048
– volume: 9
  start-page: 357
  year: 2012
  ident: 16890_CR92
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1923
– volume: 49
  start-page: 1175
  year: 2018
  ident: 16890_CR35
  publication-title: Immunity
  doi: 10.1016/j.immuni.2018.10.007
– volume: 8
  start-page: 34128
  year: 2017
  ident: 16890_CR55
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.16699
– volume: 30
  start-page: S163
  year: 2013
  ident: 16890_CR45
  publication-title: Brain. Behav. Immun.
  doi: 10.1016/j.bbi.2012.07.019
– volume: 32
  start-page: 792
  year: 2004
  ident: 16890_CR65
  publication-title: Biochem. Soc. Trans.
  doi: 10.1042/BST0320792
– volume: 22
  start-page: 448
  year: 2015
  ident: 16890_CR53
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2015.06.005
– volume: 410
  start-page: 50
  year: 2001
  ident: 16890_CR41
  publication-title: Nature
  doi: 10.1038/35065016
– volume: 2
  start-page: e377
  year: 2004
  ident: 16890_CR54
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.0020377
– volume: 13
  start-page: 3282
  year: 2014
  ident: 16890_CR8
  publication-title: Cell Cycle
  doi: 10.4161/15384101.2014.954454
– volume: 69
  start-page: 110
  year: 2017
  ident: 16890_CR32
  publication-title: Hum. Pathol.
  doi: 10.1016/j.humpath.2017.09.012
– volume: 1
  year: 2015
  ident: 16890_CR72
  publication-title: Npj Breast Cancer
  doi: 10.1038/npjbcancer.2015.7
– volume: 16
  start-page: 193
  year: 2007
  ident: 16890_CR16
  publication-title: Transgenic Res.
  doi: 10.1007/s11248-006-9056-9
– volume: 111
  start-page: 41
  year: 2002
  ident: 16890_CR28
  publication-title: Cell
  doi: 10.1016/S0092-8674(02)00961-3
– volume: 26
  start-page: 1808
  year: 2012
  ident: 16890_CR68
  publication-title: Mol. Endocrinol.
  doi: 10.1210/me.2012-1071
– volume: 24
  start-page: 324
  year: 2016
  ident: 16890_CR59
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2016.07.001
– volume: 12
  start-page: 954
  year: 1992
  ident: 16890_CR15
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.12.3.954
– volume: 139
  start-page: 1077
  year: 2010
  ident: 16890_CR10
  publication-title: Reproduction
  doi: 10.1530/REP-09-0523
– volume: 177
  start-page: 1436
  year: 2019
  ident: 16890_CR66
  publication-title: Cell
  doi: 10.1016/j.cell.2019.05.009
– volume: 308
  start-page: 91
  year: 2011
  ident: 16890_CR39
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2011.04.018
– volume: 128
  start-page: 1758
  year: 2013
  ident: 16890_CR50
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.113.002885
– volume: 11
  start-page: e0150606
  year: 2016
  ident: 16890_CR30
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0150606
– volume: 452
  start-page: 442
  year: 2008
  ident: 16890_CR85
  publication-title: Nature
  doi: 10.1038/nature06685
– volume: 16
  year: 2018
  ident: 16890_CR7
  publication-title: BMC Med.
  doi: 10.1186/s12916-018-1010-1
– volume: 116
  start-page: 4558
  year: 2019
  ident: 16890_CR87
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1815515116
– volume: 93
  start-page: 1563
  year: 2001
  ident: 16890_CR3
  publication-title: JNCI J. Natl Cancer Inst.
  doi: 10.1093/jnci/93.20.1563
– volume: 8
  year: 2019
  ident: 16890_CR38
  publication-title: Oncogenesis
  doi: 10.1038/s41389-018-0117-8
– volume: 6
  start-page: e012580
  year: 2016
  ident: 16890_CR2
  publication-title: BMJ Open
  doi: 10.1136/bmjopen-2016-012580
– volume: 3
  start-page: e2888
  year: 2008
  ident: 16890_CR22
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0002888
– volume: 439
  start-page: 84
  year: 2006
  ident: 16890_CR24
  publication-title: Nature
  doi: 10.1038/nature04372
– volume: 36
  start-page: 1307
  year: 2020
  ident: 16890_CR97
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btz700
– volume: 110
  start-page: 1732
  year: 2011
  ident: 16890_CR78
  publication-title: J. Appl. Physiol.
  doi: 10.1152/japplphysiol.00079.2011
– volume: 50
  start-page: 463
  year: 1992
  ident: 16890_CR89
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.2910500323
– volume: 35
  start-page: 1689
  year: 2018
  ident: 16890_CR29
  publication-title: Chronobiol. Int.
  doi: 10.1080/07420528.2018.1508151
– volume: 97
  start-page: 507
  year: 2005
  ident: 16890_CR57
  publication-title: JNCI J. Natl Cancer Inst.
  doi: 10.1093/jnci/dji083
– volume: 13
  start-page: e1005752
  year: 2017
  ident: 16890_CR95
  publication-title: PLoS Comput. Biol.
  doi: 10.1371/journal.pcbi.1005752
– volume: 150
  start-page: 165
  year: 2012
  ident: 16890_CR44
  publication-title: Cell
  doi: 10.1016/j.cell.2012.04.042
– volume: 13
  start-page: 1563
  year: 2004
  ident: 16890_CR62
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddh173
– volume: 25
  start-page: 1932
  year: 2015
  ident: 16890_CR14
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2015.06.012
– volume: 130
  start-page: 1995
  year: 2017
  ident: 16890_CR77
  publication-title: Blood
  doi: 10.1182/blood-2017-04-778779
– volume: 104
  start-page: 10069
  year: 2007
  ident: 16890_CR71
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0703900104
– volume: 147
  start-page: 1916
  year: 2006
  ident: 16890_CR11
  publication-title: Endocrinology
  doi: 10.1210/en.2005-1343
– volume: 33
  start-page: 6566
  year: 2005
  ident: 16890_CR70
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gki965
– volume: 6
  start-page: e1356965
  year: 2017
  ident: 16890_CR81
  publication-title: OncoImmunology
  doi: 10.1080/2162402X.2017.1356965
– volume: 8
  start-page: 185
  year: 2018
  ident: 16890_CR88
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2018.00185
– ident: 16890_CR46
  doi: 10.1101/622050
– volume: 22
  start-page: 709
  year: 2012
  ident: 16890_CR73
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.10.012
– volume: 110
  start-page: 12331
  year: 2013
  ident: 16890_CR13
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1222684110
– volume: 4
  start-page: e12743
  year: 2016
  ident: 16890_CR19
  publication-title: Physiol. Rep.
  doi: 10.14814/phy2.12743
– volume: 30
  start-page: 870
  year: 2013
  ident: 16890_CR74
  publication-title: Chronobiol. Int.
  doi: 10.3109/07420528.2013.782315
– volume: 525
  start-page: 256
  year: 2015
  ident: 16890_CR47
  publication-title: Nature
  doi: 10.1038/nature14897
– volume: 4
  start-page: 325
  year: 2017
  ident: 16890_CR4
  publication-title: Curr. Environ. Health Rep.
  doi: 10.1007/s40572-017-0155-y
– volume: 10
  year: 2019
  ident: 16890_CR84
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-12108-6
– volume: 84
  start-page: 35
  year: 2018
  ident: 16890_CR5
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2017.10.011
– volume: 68
  start-page: 394
  year: 2018
  ident: 16890_CR1
  publication-title: Ca. Cancer J. Clin.
  doi: 10.3322/caac.21492
– volume: 465
  start-page: 556
  year: 2015
  ident: 16890_CR18
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2015.08.059
– volume: 115
  start-page: 10094
  year: 2018
  ident: 16890_CR82
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1800695115
– volume: 16
  year: 2016
  ident: 16890_CR34
  publication-title: BMC Cancer
  doi: 10.1186/s12885-016-2732-0
– volume: 102
  start-page: 15545
  year: 2005
  ident: 16890_CR98
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0506580102
– volume: 119
  start-page: 131
  year: 2016
  ident: 16890_CR51
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.116.308034
– volume: 33
  start-page: 369
  year: 2018
  ident: 16890_CR6
  publication-title: Eur. J. Epidemiol.
  doi: 10.1007/s10654-018-0368-x
– volume: 278
  start-page: 21631
  year: 2003
  ident: 16890_CR42
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M300609200
– volume: 28
  start-page: 3770
  year: 2010
  ident: 16890_CR60
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2009.27.0215
– volume: 70
  start-page: 3351
  year: 2010
  ident: 16890_CR58
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-09-4235
– volume: 115
  start-page: E4041
  year: 2018
  ident: 16890_CR83
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1720948115
– volume: 26
  start-page: 464
  year: 2011
  ident: 16890_CR91
  publication-title: J. Biol. Rhythms
  doi: 10.1177/0748730411414264
SSID ssj0000391844
Score 2.6288397
Snippet Breast cancer is the most common type of cancer worldwide and one of the major causes of cancer death in women. Epidemiological studies have established a link...
Circadian disruption is implicated in the development of different human cancers. Here the authors show that chronic circadian disruption, through continuous...
SourceID doaj
pubmedcentral
hal
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 3193
SubjectTerms 13/100
13/21
13/31
38/91
59/5
631/67/1347
631/67/327
631/67/71
631/80/105
64/60
96/63
Animals
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - immunology
Breast Neoplasms - pathology
Cancer
Carcinogenesis
Carcinogens
Cell Transformation, Neoplastic - drug effects
Chronic Disease
Chronobiology Disorders - complications
Chronobiology Disorders - genetics
Chronobiology Disorders - immunology
Circadian rhythms
CXCR2 protein
Cytokines - genetics
Disruption
Epidemiology
Female
Gene Expression Regulation
Health risks
Humanities and Social Sciences
Immunosuppression
Jet lag
Life Sciences
Light Signal Transduction - genetics
Lung cancer
Metastases
Metastasis
Mice
Mice, Transgenic
multidisciplinary
Neoplasm Metastasis - prevention & control
Receptors, Interleukin-8B - antagonists & inhibitors
Receptors, Interleukin-8B - genetics
Science
Science (multidisciplinary)
Shift work
Tumor microenvironment
Tumor Microenvironment - immunology
Tumorigenesis
Tumors
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3di9QwEA9yIPginp_1TomgT1oubdImfTzFYxH1yYN7C_nkCm5X2q7gf-9M2l23HuqLj92mbXZmMvMbMvkNIS-FjUHYps597ctcQAjKTWPg0orAKqtMlaoqP32uV5fiw1V1ddDqC2vCJnrgSXBnDYeQVDHDAoT-GKQxYJNlaYS1kQmf2Esh5h0kU8kH8wZSFzGfkmFcnQ0i-QTMlopaNZAzLSJRIuyH-HKN5ZA3sebNksnf9k1TOLq4R-7OOJKeT_M_JrdCd5_cnjpL_nhAtjPpLXVt7xL9APXt0G-Tg6DrjceuXWGgFmvSR-pQ9z1FUmd0fdR0nrZ4ciTQNVbsHRyHo-OG-h58JF2HEZ41QzvQtsNx4SG5vHj_5d0qnzss5A6QyJinY6lWSZdwhHM-RGktCwATJGC50gH64lbEiksuZVSscYZhpbV33IhS8EfkqNt04QmhUUauWORV8AASrGhMrGTJY2WZZb4oMlLspK3dTD-OXTC-6rQNzpWeNKRBQzppSNcZeb1_5ttEvvHX0W9RifuRSJydfgBz0rM56X-ZU0ZegQks3rE6_6jbDhzCGr7WYP4rv8PfOd0ZiZ5X_aBLRLcMJKUy8mJ_G9YrbsKYLmy2aQz2WQWQkJHHk03tv8bLSiHFXkbkwtoW01ne6drrxAkueSGkajLyZmeXv6b1Z5E9_R8iOyF3SlxWrM5LcUqOxn4bngFSG-3ztCh_AuaOOMc
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELZKERIXxJuUgowEJwh4YydODggVRLVClBMr9Wb52UbqJpBkK_rvmXGyC0tLj5vYm8T-ZuYbeR6EvBQmeGGqInWFy1IBJijVlYafRniWm1LnMary6FsxX4gvx_nxDlm3O5oWsL_StcN-Uovu7O2vnxcfQODfjynj5bteRHFHR2hWlBW4QzfITbBMBaL8aKL7UTPzChwaMeXOXD11yz7FMv5gdU4xSPIyA70cSPnPaWo0Uod3yZ2JXdKDEQ73yI5v7pNbY7_JiwdkNZXCpbbubCxKQF3dd6uoNuiyddjLy_fUYKT6QC0ioqNY6hkVItWNozXmk3i6xDi-v5Lk6NBS14HmpEs_wFzd1z2tGxznH5LF4efvn-bp1HchtcBPhjQmq5pS2sgurHU-SGOYB_IggeFlFjgZNyLkXHIpQ8kqqxnGXzvLtcgEf0R2m7bxTwgNMvCSBZ57B9TBiEqHXGY85IYZ5mazhMzWq63sVJQce2OcqXg4zks17pCCHVJxh1SRkNebOT_GkhzXjv6Im7gZieW044W2O1GTdKqKA-_JmWYe-GXwUmtQfFmmhTGBCZcn5BVAYOs_5gdfVd2AmljC0yr0iuU5fM7-GiRqDWWFSASiIGWZkBeb2yDFeDSjG9-u4hjsvgrUISGPR0xtnsazvMTCewmRW2jbep3tO019GiuFSz4TsqwS8maNyz-v9f8l27v-K56S2xkKDCvSTOyT3aFb-WfAzAbzPIrbbzNXM_w
  priority: 102
  providerName: Scholars Portal
– databaseName: Springer Nature OA Free Journals
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lj9MwELaWRUhcEG8CCzISnCDCtZ3YOS4VqwoBJ1bam-UnG2mboiRF2n-_M25aKAtIHNOME9fz8Od45jMhr6RLUbqmLkMdeClhCiptY-HSycgqp22Vsyo_f6kXp_LjWXV2QPi2FiYn7WdKyxymt9lh7waZXRoXO7NaN7DkuUFuInU78uXP6_nuuwoynmspp_oYJvQfmu7NQZmqH2aWc0yEvI4yrydL_rZjmieik7vkzoQg6fGmz_fIQezuk1ubMyUvH5D1RHdLfdv7TDxAQzv06xwa6HIV8LyuOFCH2egj9aj1niKdMwY9artAW6wZiXSJuXq_FMLRcUVDD9GRLuMIbe3QDrTtUC4-JKcnH77OF-V0tkLpAYOMZS5IdVr5jCC8DzEp51gEgKAAxXEPuEs4mSqhhFJJs8ZbhjnWwQsruRSPyGG36uITQpNKQrMkqhgAHjjZ2FQpLlLlmGNhNivIbDvaxk_E43j-xYXJG-BCm42GDGjIZA2ZuiBvdm2-b2g3_in9HpW4k0TK7PzDqv9mJhMyjQBsUzHLImDIFJW1ENw4t9K5xGSoCvIaTGDvGYvjT6btIBQs4W0NrnzVD_g7R1sjMZO_D4YjrmUwUrogL3e3wVNx-8V2cbXOMnjCKsCDgjze2NTubYJXGsn1CqL2rG2vO_t3uvY8s4ErMZNKNwV5u7XLn936-5A9_T_xZ-Q2RwdidcnlETkc-3V8DmhsdC-y-10BWWMulA
  priority: 102
  providerName: Springer Nature
Title Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
URI https://link.springer.com/article/10.1038/s41467-020-16890-6
https://www.ncbi.nlm.nih.gov/pubmed/32581213
https://www.proquest.com/docview/2416303778
https://www.proquest.com/docview/2417386067
https://inserm.hal.science/inserm-02907177
https://pubmed.ncbi.nlm.nih.gov/PMC7314789
https://doaj.org/article/9351250a0e324fe7aa73022a4bbf04d5
Volume 11
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bb9MwFLZYKyReEHcCozISPEE0N3Zi5wl11UpVsQkBk_YW-RYWiSYjaZH495zjph1lYi-REjsX51z82T7-DiFvhCm9MHkWu8wlsYAuKNa5hlMjPEuN0mmIqjw9y-bnYnGRXvQTbl0fVrn1icFRu8biHPlRgsiBcSnVh6ufMWaNwtXVPoXGARmCC1bpgAyPT84-f9nNsiD_uRKi3y3DuDrqRPANOGoaZyqHsdNejxSI-6GfucSwyJuY82bo5D_rp6Fbmj0g93s8SScbBXhI7vj6Ebm7yTD5-zFZ9-S31FatDTQE1FVduw6Ogi4bh9m7fEcNxqavqEUdaCmSO6MLpLp2tMIdJJ4uMXLvr21xdNVQ14KvpEu_gnt1V3W0qrGef0LOZyffpvO4z7QQW0AkqzhsTzVK2oAnrHW-lMYwD3BBAqZLLKAwbkSZcgkSKBXLrWYYce0s1yIR_CkZ1E3tnxNaypIrVvLUOwALRuS6TGXCy9Qww9x4HJHx9m8Xtqchx2wYP4qwHM5VsZFQARIqgoSKLCLvdvdcbUg4bq19jELc1UQC7XChab8XvT0WOQekkzLNPCDK0kutwdUliRbGlEy4NCJvQQX2njGffCqqGhzDEt6W4zhY_oLmHG6VpOitvyuudTUir3fFYLe4GKNr36xDHcy3CmAhIs82OrV7G09ShVR7EZF72rb3OfsldXUZuMElHwup8oi83-rl9Wf9_5e9uL0VL8m9BA2GZXEiDslg1a79K8BiKzMiB_JCwlHNPo7IcDJZfF2MeiOEq9NsOgqzHHA8FeoPOVo4LQ
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELZKEYIL4k2ggJHoCaJ6bSdODgiVR9nSbU-t1FuwHYdGYpOSZEH9U_xGZpxky1LRW4-7ceIkM_PNOJ75hpBX0hROmjQO8zjnoQQXFOpUw08jHYtMoiOfVbl_EE-P5Jfj6HiN_B5rYTCtcsRED9R5bfEb-RbHyIEJpZJ3pz9C7BqFu6tjC41eLfbc2S9YsrVvdz-CfDc53_l0-GEaDl0FQgvetwt9KaZJlPW-09rcFcoY5sA1KohfuIWIQxhZRELBbEXCUqsZZhfnVmjJpYDrXiPXpRApcvUnO5-X33SQbT2RcqjNYSLZaqVHIlyjTeIkhZXaiv_zbQLAq51gEubFCPdiouY_u7XeCe7cIbeH6JVu9-p2l6y56h650fezPLtPFgPVLrVlYz3pAc3Ltll4WKLzOsdeYa6lBjPhO2pR4xqKVNIIuFRXOS2xXsXROeYJ_lWER7ua5g0gM527Ds7VbdnSssJx7gE5uhIJPCTrVV25x4QWqhAJK0TkcghNjEx1ESkuisgww_LJJCCT8W1ndiA9x94b3zO_-S6SrJdQBhLKvISyOCCvl-ec9pQfl45-j0JcjkS6bv9H3XzLBuvPUgFxVcQ0cxC_Fk5pDcDKuZbGFEzmUUA2QQVWrjHdnmVlBTA0h9lSXHWrn_A4G6OSZAPWtNm5ZQTk5fIwoARu_ejK1Qs_Bru7QmgSkEe9Ti1nEzxKkNgvIGpF21ZuZ_VIVZ54JnIlJlIlaUDejHp5flv_f2VPLn-KF-Tm9HB_ls12D_aeklscjYfFIZcbZL1rFu4ZRIGdee5Nj5KvV23rfwCGVWxM
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELbKViAuiDeBAkaiJ4jWGztxckCopV21tKwqRKXegu04NBKblCQL6l_j1zHjJFuWit563I0TJ5mZbz7H8yDktdC5FTqJ_CzKAl-AC_JVouCnFpaFOlahi6r8NIv2jsXHk_BkjfwecmEwrHLARAfUWWXwG_k4QObAuJTxOO_DIo52pu_PfvjYQQp3Wod2Gp2KHNjzX7B8a97t74CsN4Nguvvlw57fdxjwDXji1ndpmTqWxvlRYzKbS62ZBTcpgcsEBtgH1yIPuYSZ85glRjGMNM4MVyIQHK57g6xL8IrxiKxv786OPi-_8GDt9ViIPlOH8XjcCIdLuGKbRHEC67YVb-iaBoCPO8WQzMt893LY5j97t84lTu-SOz2XpVud8t0ja7a8T2523S3PH5BFX3iXmqI2rgQCzYqmXjiQovMqw85htqEa4-JbalD_aoqFpRF-qSozWmD2iqVzjBr8KyWPthXNasBpOrctnKuaoqFFiePsQ3J8LTJ4REZlVdonhOYy5zHLeWgzICpaJCoPZcDzUDPNssnEI5PhbaemL4GOnTi-p24rnsdpJ6EUJJQ6CaWRR94szznrCoBcOXobhbgcicW73R9V_S3tsSBNOLCskClmgc3mVioFMBsESmidM5GFHtkEFVi5xt7WYVqUAEpzmC3BNbj8CY-zMShJ2iNPk17YiUdeLQ8DZuBGkCpttXBjsNcrEBWPPO50ajkbD8IYy_x5RK5o28rtrB4pi1NXl1zyiZBx4pG3g15e3Nb_X9nTq5_iJbkFdp4e7s8OnpHbAdoOi_xAbJBRWy_sc6CErX7R2x4lX6_b3P8A7eJx5w
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Chronic+circadian+disruption+modulates+breast+cancer+stemness+and+immune+microenvironment+to+drive+metastasis+in+mice&rft.jtitle=Nature+communications&rft.au=Hadadi+Eva&rft.au=Taylor%2C+William&rft.au=Xiao-Mei%2C+Li&rft.au=Aslan+Yetki&rft.date=2020-06-24&rft.pub=Nature+Publishing+Group&rft.eissn=2041-1723&rft.volume=11&rft.issue=1&rft_id=info:doi/10.1038%2Fs41467-020-16890-6&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon