Notch3 Is Necessary for Blood Vessel Integrity in the Central Nervous System

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 35; no. 2; pp. 409 - 420
• Main Authors: Henshall, Tanya L., Keller, Annika, He, Liqun, Johansson, Bengt R., Wallgard, Elisabet, Raschperger, Elisabeth, Mäe, Maarja Andaloussi, Jin, Shaobo, Betsholtz, Christer, Lendahl, Urban
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.02.2015
• Subjects: Actins - genetics; Actins - metabolism; aneurysm; Animals; Apoptosis; AUTOSOMAL-DOMINANT ARTERIOPATHY; Biomarkers - metabolism; Blood Vessels - metabolism; blood-brain barrier; Blood-Brain Barrier - metabolism; Blood-Brain Barrier - pathology; BRAIN-BARRIER; CADASIL; Capillary Permeability; DISEASE; Endothelial Cells - metabolism; EXPRESSION; Female; fibrin; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genotype; Hematologi; Hematology; INFARCTS; ISCHEMIC-STROKE; LEUKOENCEPHALOPATHY; Male; Mice, Inbred C57BL; Mice, Knockout; Microvessels - metabolism; Microvessels - pathology; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; Notch3; Pericytes - metabolism; Peripheral Vascular Disease; Phenotype; Receptor, Notch3; Receptors, Notch - deficiency; Receptors, Notch - genetics; Receptors, Notch - metabolism; Retinal Vessels - metabolism; Retinal Vessels - pathology; Signal Transduction; smooth muscle; SMOOTH-MUSCLE-CELLS; SUBCORTICAL; Transcription, Genetic; VASCULAR INTEGRITY; blood-brain barrier; smooth muscle; aneurysm; fibrin; Notch3

OBJECTIVE—Vascular smooth muscle cells (VSMC) are important for contraction, blood flow distribution, and regulation of blood vessel diameter, but to what extent they contribute to the integrity of blood vessels and blood–brain barrier function is less well understood. In this report, we explored th...