Fluorine as a Hydrogen-Bond Acceptor: Experimental Evidence and Computational Calculations

• Published in: Chemistry : a European journal Vol. 20; no. 35; pp. 11058 - 11068
• Main Authors: Dalvit, Claudio, Invernizzi, Christian, Vulpetti, Anna
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 25.08.2014; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Bonding; Chemical bonds; Computation; Computer Simulation; Correlation; Drug Design; Fluorine; Fluorine - chemistry; Hydrogen; Hydrogen Bonding; Hydrogen bonds; Magnetic Resonance Spectroscopy; molecular electrostatic potential; NMR spectroscopy; noncovalent interactions; Nuclear magnetic resonance; Thermodynamics; Topology; molecular electrostatic potential; NMR spectroscopy; noncovalent interactions; hydrogen bonds; fluorine

Hydrogen‐bonding interactions play an important role in many chemical and biological systems. Fluorine acting as a hydrogen‐bond acceptor in intermolecular and intramolecular interactions has been the subject of many controversial discussions and there are different opinions about it. Recently, we h...