Endoscopic features of lymphoid follicles in the colonic mucosa using the image enhanced endoscopy and its association with colorectal adenoma
Lymphoid follicles hyperplasia (LH) is sometimes observed in the normal colon as small, round, yellowish-white nodules. LH is associated with food hypersensitivity and bowel symptoms and histologically characterized as intense infiltration of lymphocytes or plasmacytes. It is suggested that LH repre...
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| Published in | PloS one Vol. 18; no. 5; p. e0286300 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Public Library of Science
30.05.2023
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| Abstract | Lymphoid follicles hyperplasia (LH) is sometimes observed in the normal colon as small, round, yellowish-white nodules. LH is associated with food hypersensitivity and bowel symptoms and histologically characterized as intense infiltration of lymphocytes or plasmacytes. It is suggested that LH represents inflammatory immune response in the colonic mucosa. We investigated the presence of LH in the normal colonic mucosa and its association with incidence of colorectal lesions including colorectal cancer, adenoma and hyperplastic polyp.
605 participants undergoing colonoscopy for various indications were enrolled. Presence of LH in the proximal colon (appendix, cecum and the ascending colon) was observed using the blue laser imaging (BLI) endoscopy, a new generation image enhanced endoscopy (IEE) system. LH was defined as well demarcated white nodules. Elevated LH with erythema was distinguished as LH severe. Association between presence of LH and occurrence of colorectal lesions was investigated.
Prevalence of all colorectal lesions and adenoma were significantly lower in LH severe group compared to the LH negative group (P = 0.0008, 0.0009, respectively). Mean number of all colorectal lesions and adenoma were also lower in LH severe group compared to the LH negative group (P = 0.005, 0.003 respectively). The logistic regression with adjustment for gender and age demonstrated that presence of LH severe held significantly lower risk of all colorectal lesions (OR = 0.48, 95%CI = 0.27-0.86) and adenoma (OR = 0.47, 95%CI = 0.26-0.86).
LH in the colonic mucosa visualized by IEE is useful endoscopic finding to predict risk of colorectal adenoma. |
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| AbstractList | Background/Aim Lymphoid follicles hyperplasia (LH) is sometimes observed in the normal colon as small, round, yellowish-white nodules. LH is associated with food hypersensitivity and bowel symptoms and histologically characterized as intense infiltration of lymphocytes or plasmacytes. It is suggested that LH represents inflammatory immune response in the colonic mucosa. We investigated the presence of LH in the normal colonic mucosa and its association with incidence of colorectal lesions including colorectal cancer, adenoma and hyperplastic polyp. Patients/Methods 605 participants undergoing colonoscopy for various indications were enrolled. Presence of LH in the proximal colon (appendix, cecum and the ascending colon) was observed using the blue laser imaging (BLI) endoscopy, a new generation image enhanced endoscopy (IEE) system. LH was defined as well demarcated white nodules. Elevated LH with erythema was distinguished as LH severe. Association between presence of LH and occurrence of colorectal lesions was investigated. Results Prevalence of all colorectal lesions and adenoma were significantly lower in LH severe group compared to the LH negative group (P = 0.0008, 0.0009, respectively). Mean number of all colorectal lesions and adenoma were also lower in LH severe group compared to the LH negative group (P = 0.005, 0.003 respectively). The logistic regression with adjustment for gender and age demonstrated that presence of LH severe held significantly lower risk of all colorectal lesions (OR = 0.48, 95%CI = 0.27-0.86) and adenoma (OR = 0.47, 95%CI = 0.26-0.86). Conclusion LH in the colonic mucosa visualized by IEE is useful endoscopic finding to predict risk of colorectal adenoma. Lymphoid follicles hyperplasia (LH) is sometimes observed in the normal colon as small, round, yellowish-white nodules. LH is associated with food hypersensitivity and bowel symptoms and histologically characterized as intense infiltration of lymphocytes or plasmacytes. It is suggested that LH represents inflammatory immune response in the colonic mucosa. We investigated the presence of LH in the normal colonic mucosa and its association with incidence of colorectal lesions including colorectal cancer, adenoma and hyperplastic polyp.BACKGROUND/AIMLymphoid follicles hyperplasia (LH) is sometimes observed in the normal colon as small, round, yellowish-white nodules. LH is associated with food hypersensitivity and bowel symptoms and histologically characterized as intense infiltration of lymphocytes or plasmacytes. It is suggested that LH represents inflammatory immune response in the colonic mucosa. We investigated the presence of LH in the normal colonic mucosa and its association with incidence of colorectal lesions including colorectal cancer, adenoma and hyperplastic polyp.605 participants undergoing colonoscopy for various indications were enrolled. Presence of LH in the proximal colon (appendix, cecum and the ascending colon) was observed using the blue laser imaging (BLI) endoscopy, a new generation image enhanced endoscopy (IEE) system. LH was defined as well demarcated white nodules. Elevated LH with erythema was distinguished as LH severe. Association between presence of LH and occurrence of colorectal lesions was investigated.PATIENTS/METHODS605 participants undergoing colonoscopy for various indications were enrolled. Presence of LH in the proximal colon (appendix, cecum and the ascending colon) was observed using the blue laser imaging (BLI) endoscopy, a new generation image enhanced endoscopy (IEE) system. LH was defined as well demarcated white nodules. Elevated LH with erythema was distinguished as LH severe. Association between presence of LH and occurrence of colorectal lesions was investigated.Prevalence of all colorectal lesions and adenoma were significantly lower in LH severe group compared to the LH negative group (P = 0.0008, 0.0009, respectively). Mean number of all colorectal lesions and adenoma were also lower in LH severe group compared to the LH negative group (P = 0.005, 0.003 respectively). The logistic regression with adjustment for gender and age demonstrated that presence of LH severe held significantly lower risk of all colorectal lesions (OR = 0.48, 95%CI = 0.27-0.86) and adenoma (OR = 0.47, 95%CI = 0.26-0.86).RESULTSPrevalence of all colorectal lesions and adenoma were significantly lower in LH severe group compared to the LH negative group (P = 0.0008, 0.0009, respectively). Mean number of all colorectal lesions and adenoma were also lower in LH severe group compared to the LH negative group (P = 0.005, 0.003 respectively). The logistic regression with adjustment for gender and age demonstrated that presence of LH severe held significantly lower risk of all colorectal lesions (OR = 0.48, 95%CI = 0.27-0.86) and adenoma (OR = 0.47, 95%CI = 0.26-0.86).LH in the colonic mucosa visualized by IEE is useful endoscopic finding to predict risk of colorectal adenoma.CONCLUSIONLH in the colonic mucosa visualized by IEE is useful endoscopic finding to predict risk of colorectal adenoma. Lymphoid follicles hyperplasia (LH) is sometimes observed in the normal colon as small, round, yellowish-white nodules. LH is associated with food hypersensitivity and bowel symptoms and histologically characterized as intense infiltration of lymphocytes or plasmacytes. It is suggested that LH represents inflammatory immune response in the colonic mucosa. We investigated the presence of LH in the normal colonic mucosa and its association with incidence of colorectal lesions including colorectal cancer, adenoma and hyperplastic polyp. 605 participants undergoing colonoscopy for various indications were enrolled. Presence of LH in the proximal colon (appendix, cecum and the ascending colon) was observed using the blue laser imaging (BLI) endoscopy, a new generation image enhanced endoscopy (IEE) system. LH was defined as well demarcated white nodules. Elevated LH with erythema was distinguished as LH severe. Association between presence of LH and occurrence of colorectal lesions was investigated. Prevalence of all colorectal lesions and adenoma were significantly lower in LH severe group compared to the LH negative group (P = 0.0008, 0.0009, respectively). Mean number of all colorectal lesions and adenoma were also lower in LH severe group compared to the LH negative group (P = 0.005, 0.003 respectively). The logistic regression with adjustment for gender and age demonstrated that presence of LH severe held significantly lower risk of all colorectal lesions (OR = 0.48, 95%CI = 0.27-0.86) and adenoma (OR = 0.47, 95%CI = 0.26-0.86). LH in the colonic mucosa visualized by IEE is useful endoscopic finding to predict risk of colorectal adenoma. Lymphoid follicles hyperplasia (LH) is sometimes observed in the normal colon as small, round, yellowish-white nodules. LH is associated with food hypersensitivity and bowel symptoms and histologically characterized as intense infiltration of lymphocytes or plasmacytes. It is suggested that LH represents inflammatory immune response in the colonic mucosa. We investigated the presence of LH in the normal colonic mucosa and its association with incidence of colorectal lesions including colorectal cancer, adenoma and hyperplastic polyp. 605 participants undergoing colonoscopy for various indications were enrolled. Presence of LH in the proximal colon (appendix, cecum and the ascending colon) was observed using the blue laser imaging (BLI) endoscopy, a new generation image enhanced endoscopy (IEE) system. LH was defined as well demarcated white nodules. Elevated LH with erythema was distinguished as LH severe. Association between presence of LH and occurrence of colorectal lesions was investigated. Prevalence of all colorectal lesions and adenoma were significantly lower in LH severe group compared to the LH negative group (P = 0.0008, 0.0009, respectively). Mean number of all colorectal lesions and adenoma were also lower in LH severe group compared to the LH negative group (P = 0.005, 0.003 respectively). The logistic regression with adjustment for gender and age demonstrated that presence of LH severe held significantly lower risk of all colorectal lesions (OR = 0.48, 95%CI = 0.27-0.86) and adenoma (OR = 0.47, 95%CI = 0.26-0.86). LH in the colonic mucosa visualized by IEE is useful endoscopic finding to predict risk of colorectal adenoma. Background/aimLymphoid follicles hyperplasia (LH) is sometimes observed in the normal colon as small, round, yellowish-white nodules. LH is associated with food hypersensitivity and bowel symptoms and histologically characterized as intense infiltration of lymphocytes or plasmacytes. It is suggested that LH represents inflammatory immune response in the colonic mucosa. We investigated the presence of LH in the normal colonic mucosa and its association with incidence of colorectal lesions including colorectal cancer, adenoma and hyperplastic polyp.Patients/methods605 participants undergoing colonoscopy for various indications were enrolled. Presence of LH in the proximal colon (appendix, cecum and the ascending colon) was observed using the blue laser imaging (BLI) endoscopy, a new generation image enhanced endoscopy (IEE) system. LH was defined as well demarcated white nodules. Elevated LH with erythema was distinguished as LH severe. Association between presence of LH and occurrence of colorectal lesions was investigated.ResultsPrevalence of all colorectal lesions and adenoma were significantly lower in LH severe group compared to the LH negative group (P = 0.0008, 0.0009, respectively). Mean number of all colorectal lesions and adenoma were also lower in LH severe group compared to the LH negative group (P = 0.005, 0.003 respectively). The logistic regression with adjustment for gender and age demonstrated that presence of LH severe held significantly lower risk of all colorectal lesions (OR = 0.48, 95%CI = 0.27-0.86) and adenoma (OR = 0.47, 95%CI = 0.26-0.86).ConclusionLH in the colonic mucosa visualized by IEE is useful endoscopic finding to predict risk of colorectal adenoma. Background/Aim Lymphoid follicles hyperplasia (LH) is sometimes observed in the normal colon as small, round, yellowish-white nodules. LH is associated with food hypersensitivity and bowel symptoms and histologically characterized as intense infiltration of lymphocytes or plasmacytes. It is suggested that LH represents inflammatory immune response in the colonic mucosa. We investigated the presence of LH in the normal colonic mucosa and its association with incidence of colorectal lesions including colorectal cancer, adenoma and hyperplastic polyp. Patients/Methods 605 participants undergoing colonoscopy for various indications were enrolled. Presence of LH in the proximal colon (appendix, cecum and the ascending colon) was observed using the blue laser imaging (BLI) endoscopy, a new generation image enhanced endoscopy (IEE) system. LH was defined as well demarcated white nodules. Elevated LH with erythema was distinguished as LH severe. Association between presence of LH and occurrence of colorectal lesions was investigated. Results Prevalence of all colorectal lesions and adenoma were significantly lower in LH severe group compared to the LH negative group ( P = 0.0008, 0.0009, respectively). Mean number of all colorectal lesions and adenoma were also lower in LH severe group compared to the LH negative group ( P = 0.005, 0.003 respectively). The logistic regression with adjustment for gender and age demonstrated that presence of LH severe held significantly lower risk of all colorectal lesions (OR = 0.48, 95%CI = 0.27–0.86) and adenoma (OR = 0.47, 95%CI = 0.26–0.86). Conclusion LH in the colonic mucosa visualized by IEE is useful endoscopic finding to predict risk of colorectal adenoma. |
| Audience | Academic |
| Author | Tahara, Sayumi Naganuma, Makoto Ohmiya, Naoki Shibata, Tomoyuki Tsukamoto, Tetsuya Takahama, Kazuya Tahara, Tomomitsu Funasaka, Kohei Ieda, Hiro-o Nakagawa, Yoshihito Horiguchi, Noriyuki Fukui, Toshiro |
| AuthorAffiliation | 5 Department of Diagnostic Pathology, School of Medicine, Fujita Health University, Toyoake, Japan 3 Internal Medicine, Takahama Clinic, Nishio, Japan 6 Department of Advanced Endoscopy, Fujita Health University, Toyoake, Aichi, Japan 1 Third department of Gastroenterology, Kansai Medical University, Hirakata, Japan 2 Department of Gastroenterology I, Fujita Health University School of Medicine, Toyoake, Japan 4 Endoscopic Center, Ieda Hospital, Toyota, Japan The University of Hong Kong Li Ka Shing Faculty of Medicine, HONG KONG |
| AuthorAffiliation_xml | – name: 6 Department of Advanced Endoscopy, Fujita Health University, Toyoake, Aichi, Japan – name: 4 Endoscopic Center, Ieda Hospital, Toyota, Japan – name: 3 Internal Medicine, Takahama Clinic, Nishio, Japan – name: The University of Hong Kong Li Ka Shing Faculty of Medicine, HONG KONG – name: 2 Department of Gastroenterology I, Fujita Health University School of Medicine, Toyoake, Japan – name: 1 Third department of Gastroenterology, Kansai Medical University, Hirakata, Japan – name: 5 Department of Diagnostic Pathology, School of Medicine, Fujita Health University, Toyoake, Japan |
| Author_xml | – sequence: 1 givenname: Tomomitsu orcidid: 0000-0002-3474-8274 surname: Tahara fullname: Tahara, Tomomitsu – sequence: 2 givenname: Kazuya surname: Takahama fullname: Takahama, Kazuya – sequence: 3 givenname: Sayumi surname: Tahara fullname: Tahara, Sayumi – sequence: 4 givenname: Noriyuki surname: Horiguchi fullname: Horiguchi, Noriyuki – sequence: 5 givenname: Kohei surname: Funasaka fullname: Funasaka, Kohei – sequence: 6 givenname: Yoshihito surname: Nakagawa fullname: Nakagawa, Yoshihito – sequence: 7 givenname: Tomoyuki surname: Shibata fullname: Shibata, Tomoyuki – sequence: 8 givenname: Tetsuya surname: Tsukamoto fullname: Tsukamoto, Tetsuya – sequence: 9 givenname: Hiro-o surname: Ieda fullname: Ieda, Hiro-o – sequence: 10 givenname: Toshiro surname: Fukui fullname: Fukui, Toshiro – sequence: 11 givenname: Makoto surname: Naganuma fullname: Naganuma, Makoto – sequence: 12 givenname: Naoki surname: Ohmiya fullname: Ohmiya, Naoki |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37253036$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright: © 2023 Tahara et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. COPYRIGHT 2023 Public Library of Science 2023 Tahara et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2023 Tahara et al 2023 Tahara et al 2023 Tahara et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| DOI | 10.1371/journal.pone.0286300 |
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| References_xml | – volume: 22 start-page: 299 year: 2012 ident: pone.0286300.ref009 article-title: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma publication-title: Genome Res doi: 10.1101/gr.126516.111 – volume: 12 start-page: e0182224 ident: pone.0286300.ref007 article-title: Endoscopic features of lymphoid follicles using blue laser imaging (BLI) endoscopy in the colorectum and its association with chronic bowel symptoms. publication-title: PLoS One doi: 10.1371/journal.pone.0182224 – volume: 369 start-page: 1095 year: 2013 ident: pone.0286300.ref002 article-title: Long-term colorectal-cancer incidence and mortality after lower endoscopy publication-title: N Engl J Med doi: 10.1056/NEJMoa1301969 – ident: pone.0286300.ref003 – volume: 82 start-page: 542 year: 2015 ident: pone.0286300.ref015 article-title: Improvement in the visibility of colorectal polyps by using blue laser imaging (with video). publication-title: Gastrointest Endosc doi: 10.1016/j.gie.2015.01.030 – volume: 73 start-page: 1171 year: 2005 ident: pone.0286300.ref012 article-title: Fusobacterium nucleatum increases collagenase 3 production and migration of epithelial cells publication-title: Infect Immun doi: 10.1128/IAI.73.2.1171-1179.2005 – volume: 29 start-page: 2269 year: 2020 ident: pone.0286300.ref004 article-title: Genetic Colorectal Cancer and Adenoma Risk Variants Are Associated with Increasing Cumulative Adenoma Counts publication-title: Cancer Epidemiol Biomarkers Prev doi: 10.1158/1055-9965.EPI-20-0465 – volume: 22 start-page: 292 year: 2012 ident: pone.0286300.ref010 article-title: Genomic analysis identifies association of Fusobacterium with colorectal carcinoma publication-title: Genome Res doi: 10.1101/gr.126573.111 – volume: 68 start-page: 2907 year: 2000 ident: pone.0286300.ref013 article-title: Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier publication-title: Infect Immun doi: 10.1128/IAI.68.5.2907-2915.2000 – start-page: 132 volume-title: World Health Organization Classification of Tumours of the Digestive System year: 2010 ident: pone.0286300.ref008 – volume: 35 start-page: 1000 year: 2012 ident: pone.0286300.ref006 article-title: Review article: intestinal lymphoid nodular hyperplasia in children—the relationship to food hypersensitivity publication-title: Aliment Pharmacol Ther doi: 10.1111/j.1365-2036.2012.05062.x – volume: 17 start-page: 156 year: 2019 ident: pone.0286300.ref005 article-title: Fusobacterium nucleatum—symbiont, opportunist and oncobacterium publication-title: Nat Rev Microbiol doi: 10.1038/s41579-018-0129-6 – volume: 68 start-page: 394 ident: pone.0286300.ref001 article-title: (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. publication-title: CA Cancer J Clin doi: 10.3322/caac.21492 – volume: 68 start-page: 3140 year: 2000 ident: pone.0286300.ref011 article-title: Interactions between periodontal bacteria and human oral epithelial cells: Fusobacterium nucleatum adheres to and invades epithelial cells publication-title: Infect Immun doi: 10.1128/IAI.68.6.3140-3146.2000 – volume: 27 start-page: 53 year: 2015 ident: pone.0286300.ref014 article-title: Endoscopic features of lymphoid follicles in Helicobacter pylori-associated chronic gastritis publication-title: Dig Endosc doi: 10.1111/den.12335 |
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| Snippet | Lymphoid follicles hyperplasia (LH) is sometimes observed in the normal colon as small, round, yellowish-white nodules. LH is associated with food... Background/Aim Lymphoid follicles hyperplasia (LH) is sometimes observed in the normal colon as small, round, yellowish-white nodules. LH is associated with... Background/aimLymphoid follicles hyperplasia (LH) is sometimes observed in the normal colon as small, round, yellowish-white nodules. LH is associated with... Background/Aim Lymphoid follicles hyperplasia (LH) is sometimes observed in the normal colon as small, round, yellowish-white nodules. LH is associated with... |
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| SubjectTerms | Adenoma Adenoma - pathology Biology and Life Sciences Biopsy Cancer Cecum Colon Colonic Polyps - pathology Colonoscopy Colonoscopy - methods Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - pathology Complications and side effects Diagnosis Disease Endoscopes Endoscopy Erythema Evaluation Follicles Food allergies Food allergy Food hypersensitivity Gender Humans Hyperplasia Hyperplasia - pathology Hypersensitivity Image enhancement Immune response Inflammation Intestinal Mucosa - diagnostic imaging Intestinal Mucosa - pathology Lasers Lesions Light Lymphocytes Medical imaging Medicine and Health Sciences Mucosa Nodules Plasma Cells - pathology Polyps Surveillance Tumors |
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| Title | Endoscopic features of lymphoid follicles in the colonic mucosa using the image enhanced endoscopy and its association with colorectal adenoma |
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