Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics

• Published in: Experimental & molecular medicine Vol. 55; no. 10; pp. 2085 - 2096
• Main Authors: Lee, Yeji, Jeong, Michaela, Park, Jeongeun, Jung, Hyein, Lee, Hyukjin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2023; Springer Nature B.V; Nature Publishing Group; 생화학분자생물학회
• Subjects: 42/109; 631/61/2300; 631/61/350/354; Adaptive immunity; Biomedical and Life Sciences; Biomedicine; COVID-19; Immune response; Immune system; Immunogenicity; Immunosuppressive agents; Innate immunity; Lipids; Liposomes; Medical Biochemistry; Molecular Medicine; mRNA; mRNA Vaccines; Nanoparticles; Review; Review Article; Side effects; Stem Cells; Vaccines; 생화학

Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are recognized as foreign materials by the body and stimulate innate immunity, which in turn impacts adaptive immunity. Therefore, it is cru...