qFibrosis: A fully-quantitative innovative method incorporating histological features to facilitate accurate fibrosis scoring in animal model and chronic hepatitis B patients

• Published in: Journal of hepatology Vol. 61; no. 2; pp. 260 - 269
• Main Authors: Xu, Shuoyu, Wang, Yan, Tai, Dean C.S., Wang, Shi, Cheng, Chee Leong, Peng, Qiwen, Yan, Jie, Chen, Yongpeng, Sun, Jian, Liang, Xieer, Zhu, Youfu, Rajapakse, Jagath C., Welsch, Roy E., So, Peter T.C., Wee, Aileen, Hou, Jinlin, Yu, Hanry
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2014
• Subjects: Animals; Biopsy; Chronic hepatitis B; Collagen - analysis; Disease Models, Animal; Hepatitis B, Chronic - complications; Humans; Image analysis; Liver - pathology; Liver biopsy; Liver Cirrhosis, Experimental - diagnosis; Liver Cirrhosis, Experimental - pathology; Liver fibrosis assessment; qFibrosis; Rats; Liver biopsy; AST; PT; CI; ROC; ALT; INR; ECM; AUC; Image analysis; SHG; CV; Chronic hepatitis B; TAA; CPA; TBIL; ALB; APRI; Liver fibrosis assessment; PLT; qFibrosis; CLD; TPEF; CHB

There is increasing need for accurate assessment of liver fibrosis/cirrhosis. We aimed to develop qFibrosis, a fully-automated assessment method combining quantification of histopathological architectural features, to address unmet needs in core biopsy evaluation of fibrosis in chronic hepatitis B (...