High glucose levels promote the proliferation of breast cancer cells through GTPases

• Published in: Breast cancer targets and therapy Vol. 9; pp. 429 - 436
• Main Authors: Hou, Yilin, Zhou, Man, Xie, Jing, Chao, Ping, Feng, Qiyu, Wu, Jun
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2017; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Brain cancer; Breast cancer; Care and treatment; Cdc42; Cell culture; Cell cycle; Cell growth; Development and progression; Diabetes; EGFR; Epidermal growth factor; Genetic aspects; Glucose; Glucose metabolism; GTPases; Guanosine triphosphatase; Health aspects; Hyperglycemia; Kinases; Original Research; Phosphorylation; Proteins; Rac1; Statistical analysis; United States > US; China; hyperglycemia; breast cancer; Rac1; GTPases; EGFR; Cdc42

Hyperglycemia or diabetes mellitus (DM), which is characterized by high blood glucose levels, has been linked to an increased risk of cancer for years. However, the underlying molecular mechanisms of the pathophysiological link are not yet fully understood. In this study, we demonstrate that high gl...