High glucose levels promote the proliferation of breast cancer cells through GTPases

Hyperglycemia or diabetes mellitus (DM), which is characterized by high blood glucose levels, has been linked to an increased risk of cancer for years. However, the underlying molecular mechanisms of the pathophysiological link are not yet fully understood. In this study, we demonstrate that high gl...

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Published inBreast cancer targets and therapy Vol. 9; pp. 429 - 436
Main Authors Hou, Yilin, Zhou, Man, Xie, Jing, Chao, Ping, Feng, Qiyu, Wu, Jun
Format Journal Article
LanguageEnglish
Published New Zealand Dove Medical Press Limited 01.01.2017
Taylor & Francis Ltd
Dove Medical Press
Subjects
Brain cancer
Breast cancer
Care and treatment
Cdc42
Cell culture
Cell cycle
Cell growth
Development and progression
Diabetes
EGFR
Epidermal growth factor
Genetic aspects
Glucose
Glucose metabolism
GTPases
Guanosine triphosphatase
Health aspects
Hyperglycemia
Kinases
Original Research
Phosphorylation
Proteins
Rac1
Statistical analysis
United States > US
China
hyperglycemia
breast cancer
Rac1
GTPases
EGFR
Cdc42
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Abstract Hyperglycemia or diabetes mellitus (DM), which is characterized by high blood glucose levels, has been linked to an increased risk of cancer for years. However, the underlying molecular mechanisms of the pathophysiological link are not yet fully understood. In this study, we demonstrate that high glucose levels promote the proliferation of breast cancer cells by stimulating epidermal growth factor receptor (EGFR) activation and the Rho family GTPase Rac1 and Cdc42 mediate the corresponding signaling induced by high glucose levels. We further show that Cdc42 promotes EGFR phosphorylation by blocking EGFR degradation, which may be mediated by the Cbl proteins, whereas the Rac1-mediated EGFR phosphorylation is independent of EGFR degradation. Our findings elucidate a part of the underlying molecular mechanism of the link between high glucose levels and tumorigenesis in breast cancer and may provide new insights on the therapeutic strategy for cancer patients with diabetes or hyperglycemia.
AbstractList Hyperglycemia or diabetes mellitus (DM), which is characterized by high blood glucose levels, has been linked to an increased risk of cancer for years. However, the underlying molecular mechanisms of the pathophysiological link are not yet fully understood. In this study, we demonstrate that high glucose levels promote the proliferation of breast cancer cells by stimulating epidermal growth factor receptor (EGFR) activation and the Rho family GTPase Rac1 and Cdc42 mediate the corresponding signaling induced by high glucose levels. We further show that Cdc42 promotes EGFR phosphorylation by blocking EGFR degradation, which may be mediated by the Cbl proteins, whereas the Rac1-mediated EGFR phosphorylation is independent of EGFR degradation. Our findings elucidate a part of the underlying molecular mechanism of the link between high glucose levels and tumorigenesis in breast cancer and may provide new insights on the therapeutic strategy for cancer patients with diabetes or hyperglycemia. Keyword: hyperglycemia, breast cancer, GTPases, Rac1, Cdc42, EGFR
Hyperglycemia or diabetes mellitus (DM), which is characterized by high blood glucose levels, has been linked to an increased risk of cancer for years. However, the underlying molecular mechanisms of the pathophysiological link are not yet fully understood. In this study, we demonstrate that high glucose levels promote the proliferation of breast cancer cells by stimulating epidermal growth factor receptor (EGFR) activation and the Rho family GTPase Rac1 and Cdc42 mediate the corresponding signaling induced by high glucose levels. We further show that Cdc42 promotes EGFR phosphorylation by blocking EGFR degradation, which may be mediated by the Cbl proteins, whereas the Rac1-mediated EGFR phosphorylation is independent of EGFR degradation. Our findings elucidate a part of the underlying molecular mechanism of the link between high glucose levels and tumorigenesis in breast cancer and may provide new insights on the therapeutic strategy for cancer patients with diabetes or hyperglycemia.Hyperglycemia or diabetes mellitus (DM), which is characterized by high blood glucose levels, has been linked to an increased risk of cancer for years. However, the underlying molecular mechanisms of the pathophysiological link are not yet fully understood. In this study, we demonstrate that high glucose levels promote the proliferation of breast cancer cells by stimulating epidermal growth factor receptor (EGFR) activation and the Rho family GTPase Rac1 and Cdc42 mediate the corresponding signaling induced by high glucose levels. We further show that Cdc42 promotes EGFR phosphorylation by blocking EGFR degradation, which may be mediated by the Cbl proteins, whereas the Rac1-mediated EGFR phosphorylation is independent of EGFR degradation. Our findings elucidate a part of the underlying molecular mechanism of the link between high glucose levels and tumorigenesis in breast cancer and may provide new insights on the therapeutic strategy for cancer patients with diabetes or hyperglycemia.
Hyperglycemia or diabetes mellitus (DM), which is characterized by high blood glucose levels, has been linked to an increased risk of cancer for years. However, the underlying molecular mechanisms of the pathophysiological link are not yet fully understood. In this study, we demonstrate that high glucose levels promote the proliferation of breast cancer cells by stimulating epidermal growth factor receptor (EGFR) activation and the Rho family GTPase Rac1 and Cdc42 mediate the corresponding signaling induced by high glucose levels. We further show that Cdc42 promotes EGFR phosphorylation by blocking EGFR degradation, which may be mediated by the Cbl proteins, whereas the Rac1-mediated EGFR phosphorylation is independent of EGFR degradation. Our findings elucidate a part of the underlying molecular mechanism of the link between high glucose levels and tumorigenesis in breast cancer and may provide new insights on the therapeutic strategy for cancer patients with diabetes or hyperglycemia.
Yilin Hou,1 Man Zhou,1 Jing Xie,1 Ping Chao,1 Qiyu Feng,2 Jun Wu1 1Department of Endocrinology, The Third Hospital of Wuhan (Tongren Hospital of Wuhan University), Wuhan, People's Republic of China; 2Eastern Hepatobiliary Surgery Institute, National Center for Liver Cancer, Shanghai, People's Republic of China Abstract: Hyperglycemia or diabetes mellitus (DM), which is characterized by high blood glucose levels, has been linked to an increased risk of cancer for years. However, the underlying molecular mechanisms of the pathophysiological link are not yet fully understood. In this study, we demonstrate that high glucose levels promote the proliferation of breast cancer cells by stimulating epidermal growth factor receptor (EGFR) activation and the Rho family GTPase Rac1 and Cdc42 mediate the corresponding signaling induced by high glucose levels. We further show that Cdc42 promotes EGFR phosphorylation by blocking EGFR degradation, which may be mediated by the Cbl proteins, whereas the Rac1-mediated EGFR phosphorylation is independent of EGFR degradation. Our findings elucidate a part of the underlying molecular mechanism of the link between high glucose levels and tumorigenesis in breast cancer and may provide new insights on the therapeutic strategy for cancer patients with diabetes or hyperglycemia. Keyword: hyperglycemia, breast cancer, GTPases, Rac1, Cdc42, EGFR
Audience Academic
Author Chao, Ping
Wu, Jun
Xie, Jing
Hou, Yilin
Zhou, Man
Feng, Qiyu
AuthorAffiliation 2 Eastern Hepatobiliary Surgery Institute, National Center for Liver Cancer, Shanghai, People’s Republic of China
1 Department of Endocrinology, The Third Hospital of Wuhan (Tongren Hospital of Wuhan University), Wuhan, People’s Republic of China
AuthorAffiliation_xml – name: 1 Department of Endocrinology, The Third Hospital of Wuhan (Tongren Hospital of Wuhan University), Wuhan, People’s Republic of China
– name: 2 Eastern Hepatobiliary Surgery Institute, National Center for Liver Cancer, Shanghai, People’s Republic of China
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Keywords hyperglycemia
breast cancer
Rac1
GTPases
EGFR
Cdc42
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Snippet Hyperglycemia or diabetes mellitus (DM), which is characterized by high blood glucose levels, has been linked to an increased risk of cancer for years....
Yilin Hou,1 Man Zhou,1 Jing Xie,1 Ping Chao,1 Qiyu Feng,2 Jun Wu1 1Department of Endocrinology, The Third Hospital of Wuhan (Tongren Hospital of Wuhan...
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StartPage 429
SubjectTerms Brain cancer
Breast cancer
Care and treatment
Cdc42
Cell culture
Cell cycle
Cell growth
Development and progression
Diabetes
EGFR
Epidermal growth factor
Genetic aspects
Glucose
Glucose metabolism
GTPases
Guanosine triphosphatase
Health aspects
Hyperglycemia
Kinases
Original Research
Phosphorylation
Proteins
Rac1
Statistical analysis
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Title High glucose levels promote the proliferation of breast cancer cells through GTPases
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