Generation of vascularized brain organoids to study neurovascular interactions

• Published in: eLife Vol. 11
• Main Authors: Sun, Xin-Yao, Ju, Xiang-Chun, Li, Yang, Zeng, Peng-Ming, Wu, Jian, Zhou, Ying-Ying, Shen, Li-Bing, Dong, Jian, Chen, Yue-Jun, Luo, Zhen-Ge
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 04.05.2022; eLife Sciences Publications Ltd; eLife Sciences Publications, Ltd
• Subjects: Angiogenesis; Blood vessels; Blood-brain barrier; Brain; brain organoid; brain vasculature; Flow cytometry; Gene expression; Immune response; Medical research; Medicine, Experimental; Microglia; neural progenitors; Neural stem cells; Neurodevelopmental disorders; Neurogenesis; Neurons; Neuroscience; Organoids; Progenitor cells; Stem cells; Stem Cells and Regenerative Medicine; Synapses; Vascular endothelial growth factor; United Kingdom; stem cells; none; neuroscience; regenerative medicine

Brain organoids have been used to recapitulate the processes of brain development and related diseases. However, the lack of vasculatures, which regulate neurogenesis and brain disorders, limits the utility of brain organoids. In this study, we induced vessel and brain organoids, respectively, and t...