A new class of disordered elements controls DNA replication through initiator self-assembly - Parker, Matthew W; Bell, Maren; Mir, Mustafa; Kao, Jonchee A; Darzacq, Xavier; Botchan, Michael R; Berger, James M (eLife, 2019)
Keywords: Animals; Binding sites; Biochemistry and Chemical Biology; Cdc6; Cdt1; Cell cycle; Chromatin; Chromatin - metabolism; Chromosomes; Communication; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA helicase; DNA Replication; Drosophila; Drosophila melanogaster - genetics; Drosophila Proteins - metabolism; Genetic aspects; Glycerol; Insects; intrinsically disordered; Metazoans; Microscopy; Observations; ORC; Organizational communication; Origin recognition complex; Origin Recognition Complex - metabolism; phase separation; Phosphorylation; Protein Multimerization; Proteins; Replication initiation; Self-assembly; United States; United States--US; Cdt1; ORC; DNA replication; phase separation; chemical biology; biochemistry; Cdc6; D. melanogaster; intrinsically disordered