Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube
Astrocytes are the most abundant and functionally diverse glial population in the vertebrate central nervous system (CNS). However, the mechanisms underlying astrocyte specification are poorly understood. It is well established that cellular diversification of neurons in the embryo is generated by p...
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Published in | Nature Vol. 438; no. 7066; pp. 360 - 363 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing
17.11.2005
Nature Publishing Group |
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Abstract | Astrocytes are the most abundant and functionally diverse glial population in the vertebrate central nervous system (CNS). However, the mechanisms underlying astrocyte specification are poorly understood. It is well established that cellular diversification of neurons in the embryo is generated by position-dependent extrinsic signals and combinatorial interactions of transcription factors that direct specific cell fates by suppressing alternative fates. It is unknown whether a comparable process determines embryonic astrocyte identity. Indeed, astrocyte development is generally thought to take place in a position-independent manner. Here we show multiple functions of Stem cell leukaemia (Scl, also known as Tal1), which encodes a basic helix-loop-helix (bHLH) transcription factor, in the regulation of both astrocyte versus oligodendrocyte cell fate acquisition and V2b versus V2a interneuron cell fate acquisition in the p2 domain of the developing vertebrate spinal cord. Our findings demonstrate a regionally restricted transcriptional programme necessary for astrocyte and V2b interneuron development, with striking parallels to the involvement of SCL in haematopoiesis. They further indicate that acquisition of embryonic glial subtype identity might be regulated by genetic interactions between SCL and the transcription factor Olig2 in the ventral neural tube. |
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AbstractList | Astrocytes are the most abundant and functionally diverse glial population in the vertebrate central nervous system (CNS). However, the mechanisms underlying astrocyte specification are poorly understood. It is well established that cellular diversification of neurons in the embryo is generated by position-dependent extrinsic signals and combinatorial interactions of transcription factors that direct specific cell fates by suppressing alternative fates. It is unknown whether a comparable process determines embryonic astrocyte identity. Indeed, astrocyte development is generally thought to take place in a position-independent manner. Here we show multiple functions of Stem cell leukaemia (Scl, also known as Tal1), which encodes a basic helix-loop-helix (bHLH) transcription factor, in the regulation of both astrocyte versus oligodendrocyte cell fate acquisition and V2b versus V2a interneuron cell fate acquisition in the p2 domain of the developing vertebrate spinal cord. Our findings demonstrate a regionally restricted transcriptional programme necessary for astrocyte and V2b interneuron development, with striking parallels to the involvement of SCL in haematopoiesis. They further indicate that acquisition of embryonic glial subtype identity might be regulated by genetic interactions between SCL and the transcription factor Olig2 in the ventral neural tube. [PUBLICATION ABSTRACT] Astrocytes are the most abundant and functionally diverse glial population in the vertebrate central nervous system (CNS). However, the mechanisms underlying astrocyte specification are poorly understood. It is well established that cellular diversification of neurons in the embryo is generated by position-dependent extrinsic signals and combinatorial interactions of transcription factors that direct specific cell fates by suppressing alternative fates. It is unknown whether a comparable process determines embryonic astrocyte identity. Indeed, astrocyte development is generally thought to take place in a position-independent manner. Here we show multiple functions of Stem cell leukaemia (Scl, also known as Tal1), which encodes a basic helix-loop-helix (bHLH) transcription factor, in the regulation of both astrocyte versus oligodendrocyte cell fate acquisition and V2b versus V2a interneuron cell fate acquisition in the p2 domain of the developing vertebrate spinal cord. Our findings demonstrate a regionally restricted transcriptional programme necessary for astrocyte and V2b interneuron development, with striking parallels to the involvement of SCL in haematopoiesis. They further indicate that acquisition of embryonic glial subtype identity might be regulated by genetic interactions between SCL and the transcription factor Olig2 in the ventral neural tube. |
Audience | Academic |
Author | Rowitch, David H Fujiwara, Yuko Orkin, Stuart H Muroyama, Yuko |
Author_xml | – givenname: David H surname: Rowitch fullname: Rowitch, David H – givenname: Yuko surname: Muroyama fullname: Muroyama, Yuko – givenname: Stuart H surname: Orkin fullname: Orkin, Stuart H – givenname: Yuko surname: Fujiwara fullname: Fujiwara, Yuko |
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Copyright | 2006 INIST-CNRS COPYRIGHT 2005 Nature Publishing Group Copyright Nature Publishing Group Nov 17, 2005 |
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Keywords | Helix loop helix structure Embryo Neuroglia Central nervous system Specification Astrocyte Cell differentiation Vertebrata Mammalia Neural tube Oligodendrocyte Development Transcription factor |
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Snippet | Astrocytes are the most abundant and functionally diverse glial population in the vertebrate central nervous system (CNS). However, the mechanisms underlying... |
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SubjectTerms | Animals Astrocytes - cytology Astrocytes - metabolism Basic Helix-Loop-Helix Transcription Factors - deficiency Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Biological and medical sciences Cell Differentiation Cell Lineage Chick Embryo DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryology: invertebrates and vertebrates. Teratology Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Genes Interneurons - cytology Interneurons - metabolism Leukemia Mice Motor Neurons - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nervous system Neurology Oligodendrocyte Transcription Factor 2 Oligodendroglia - cytology Oligodendroglia - metabolism Organogenesis. Fetal development Organogenesis. Physiological fonctions Proteins Proto-Oncogene Proteins - deficiency Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Spinal Cord - cytology Spinal Cord - embryology Spinal Cord - metabolism Stem cells Stem Cells - cytology Stem Cells - metabolism T-Cell Acute Lymphocytic Leukemia Protein 1 Transcription Factors - genetics Transcription Factors - metabolism Vertebrates |
Title | Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube |
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