APP modulates KCC2 expression and function in hippocampal GABAergic inhibition

• Published in: eLife Vol. 6
• Main Authors: Chen, Ming, Wang, Jinzhao, Jiang, Jinxiang, Zheng, Xingzhi, Justice, Nicholas J, Wang, Kun, Ran, Xiangqian, Li, Yi, Huo, Qingwei, Zhang, Jiajia, Li, Hongmei, Lu, Nannan, Wang, Ying, Zheng, Hui, Long, Cheng, Yang, Li
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 05.01.2017; eLife Sciences Publications Ltd; eLife Sciences Publications, Ltd
• Subjects: Alzheimer's disease; Amyloid beta-Protein Precursor - metabolism; Amyloid precursor protein; Animals; APP; Chlorides; Depolarization; GABA; GABA reversal potential; GABAergic Neurons - physiology; Gene expression; Gene Knock-In Techniques; Genetic aspects; Hippocampus; Hippocampus (Brain); Hippocampus - physiology; Homeostasis; Humans; Inhibitory postsynaptic potentials; IPSC; KCC2; Medical research; Mice; Mice, Knockout; Neurons; Neuroscience; Observations; Phosphorylation; Physiological aspects; Potassium-chloride cotransporter; Protein interaction; protein-protein interaction; Proteins; Science; Statistical analysis; Students; Symporters - metabolism; Synapses; Synaptic transmission; Tyrosine; Ubiquitination; γ-Aminobutyric acid A receptors; APP; mouse; KCC2; hippocampus; IPSC; neuroscience; protein-protein interaction; GABA reversal potential

Amyloid precursor protein (APP) is enriched at the synapse, but its synaptic function is still poorly understood. We previously showed that GABAergic short-term plasticity is impaired in App knock-out (App-/-) animals, but the precise mechanism by which APP regulates GABAergic synaptic transmission...