APP modulates KCC2 expression and function in hippocampal GABAergic inhibition - Chen, Ming; Wang, Jinzhao; Jiang, Jinxiang; Zheng, Xingzhi; Justice, Nicholas J; Wang, Kun; Ran, Xiangqian; Li, Yi; Huo, Qingwei; Zhang, Jiajia; Li, Hongmei; Lu, Nannan; et al. (eLife, 2017)
Keywords: Alzheimer's disease; Amyloid beta-Protein Precursor - metabolism; Amyloid precursor protein; Animals; APP; Chlorides; Depolarization; GABA; GABA reversal potential; GABAergic Neurons - physiology; Gene expression; Gene Knock-In Techniques; Genetic aspects; Hippocampus; Hippocampus (Brain); Hippocampus - physiology; Homeostasis; Humans; Inhibitory postsynaptic potentials; IPSC; KCC2; Medical research; Mice; Mice, Knockout; Neurons; Neuroscience; Observations; Phosphorylation; Physiological aspects; Potassium-chloride cotransporter; Protein interaction; protein-protein interaction; Proteins; Science; Statistical analysis; Students; Symporters - metabolism; Synapses; Synaptic transmission; Tyrosine; Ubiquitination; γ-Aminobutyric acid A receptors; APP; mouse; KCC2; hippocampus; IPSC; neuroscience; protein-protein interaction; GABA reversal potential