ERCC1 which affects lipids metabolism and actin dynamics in coal workers’ pneumoconiosis is a candidate biomarker for early warning and diagnosis

• Published in: PloS one Vol. 19; no. 9; p. e0308082
• Main Authors: Deng, Hao, Chen, Yan, Wu, Mali, Zhang, Tao
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.09.2024; Public Library of Science (PLoS)
• Subjects: Actin; Actins - genetics; Actins - metabolism; Activator protein 1; Aged; Analysis; Anthracosis - blood; Anthracosis - diagnosis; Anthracosis - genetics; Anthracosis - metabolism; Anticoagulants; Biological markers; Biology and life sciences; Biomarkers; Biomarkers - blood; Care and treatment; Chromatography; Coal Mining; Damage detection; Development and progression; Diagnosis; DNA damage; DNA repair; DNA-Binding Proteins - genetics; Dust; Early Diagnosis; Endonucleases - genetics; Endonucleases - metabolism; Engineering and Technology; Enzyme-linked immunosorbent assay; Enzymes; ERCC1 protein; Ethylenediaminetetraacetic acid; Gene expression; Gene mutations; Gene polymorphism; Genes; Genotype; Genotype & phenotype; Genotypes; Health aspects; Health care; Humans; Inflammasomes; Inflammation; Lipid metabolism; Lipid Metabolism - genetics; Lipids; Liquid chromatography; Lung diseases; Male; Medical diagnosis; Medicine and Health Sciences; Metabolism; Metabolites; Middle Aged; Muscle proteins; Nucleotide sequence; Nucleotides; Occupational diseases; Oxidative stress; Peptides; Physical Sciences; Plasma; Pneumoconiosis; Polymorphism; Polymorphism, Single Nucleotide; Protein turnover; Proteins; Proteomes; Quadrupoles; Risk Factors; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Workers; China; Taiwan; United States > US

The single-nucleotide polymorphisms of genes related to DNA damage repair and inflammasomes and mutated gene expression in coal workers’ pneumoconiosis (CWP) were analysed to identify the risk factors of CWP and potential biomarkers for early warning and diagnosis. Further, mutated gene pathways wer...