Neuron-associated retroelement-derived protein Arc/Arg3.1 assists in the early stages of alphaherpesvirus infection in human neuronal cells

• Published in: PloS one Vol. 19; no. 12; p. e0314980
• Main Authors: Kobayashi, Hiroko, Yasukochi, Mitsuki, Horie, Masayuki, Orba, Yasuko, Sawa, Hirofumi, Fujino, Kan, Taharaguchi, Satoshi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.12.2024; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Antibiotics; Antibodies; Biology and life sciences; Capsid protein; Care and treatment; Cell Line; Cloning; Complications and side effects; Cytoskeletal Proteins - genetics; Cytoskeletal Proteins - metabolism; Development and progression; DNA viruses; Gene expression; Genes; Genetic aspects; Herpes; Herpes simplex; Herpes viruses; Herpesvirus 1, Human - genetics; Herpesvirus 1, Human - physiology; Herpesvirus 1, Suid - genetics; Herpesvirus 1, Suid - physiology; Herpesvirus diseases; Humans; Immunoprecipitation; Infections; Invoices; Mass spectrometry; Mass spectroscopy; Medicine and Health Sciences; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Nervous system; Nervous system diseases; Neurological diseases; Neurons - metabolism; Neurons - virology; Neuroplasticity; Pathogenesis; Penicillin; Physiological effects; Plasmids; Proteins; Research and Analysis Methods; Retroelements - genetics; Scientific imaging; Viral proteins; Virus attachment; Viruses; Japan; United States > US

Alphaherpesviruses, including herpes simplex virus type 1 (HSV-1) and pseudorabies virus (PRV), are neurotropic double-stranded DNA viruses. Alphaherpesviruses control the expression of various host factors to ensure efficient infection and propagation. Recently, HSV-1 was found to upregulate Arc/Ar...