Rapamycin rejuvenates oral health in aging mice

• Published in: eLife Vol. 9
• Main Authors: An, Jonathan Y, Kerns, Kristopher A, Ouellette, Andrew, Robinson, Laura, Morris, H Douglas, Kaczorowski, Catherine, Park, So-Il, Mekvanich, Title, Kang, Alex, McLean, Jeffrey S, Cox, Timothy C, Kaeberlein, Matt
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 28.04.2020; eLife Sciences Publications Ltd; eLife Sciences Publications, Ltd
• Subjects: Aging; Aging - physiology; Animals; Bone growth; Bone loss; Cell Biology; Dementia; dentistry; Diabetes; Drug approval; Dysbacteriosis; Dysbiosis - drug therapy; Geriatrics; Gum disease; Heart diseases; Homeostasis; Immunology and Inflammation; inflammaging; Inflammation; Life span; Mice; Mice, Inbred C57BL; microbiome; Microbiomes; NF-kappa B - physiology; Oral cavity; Oral Health; Oral hygiene; Periodontal diseases; Periodontal Diseases - drug therapy; Periodontium; Prevention; Rapamycin; Regeneration; Rejuvenation; Risk factors; Sirolimus - pharmacology; Sirolimus - therapeutic use; Statistical analysis; Tooth extractions; Canada; mouse; inflammaging; cell biology; dentistry; inflammation; gum disease; aging; immunology; microbiome; rapamycin

Periodontal disease is an age-associated disorder clinically defined by periodontal bone loss, inflammation of the specialized tissues that surround and support the tooth, and microbiome dysbiosis. Currently, there is no therapy for reversing periodontal disease, and treatment is generally restricte...