Rapamycin rejuvenates oral health in aging mice - An, Jonathan Y; Kerns, Kristopher A; Ouellette, Andrew; Robinson, Laura; Morris, H Douglas; Kaczorowski, Catherine; Park, So-Il; Mekvanich, Title; Kang, Alex; McLean, Jeffrey S; Cox, Timothy C; Kaeberlein, Matt (eLife, 2020)
Keywords: Aging; Aging - physiology; Animals; Bone growth; Bone loss; Cell Biology; Dementia; dentistry; Diabetes; Drug approval; Dysbacteriosis; Dysbiosis - drug therapy; Geriatrics; Gum disease; Heart diseases; Homeostasis; Immunology and Inflammation; inflammaging; Inflammation; Life span; Mice; Mice, Inbred C57BL; microbiome; Microbiomes; NF-kappa B - physiology; Oral cavity; Oral Health; Oral hygiene; Periodontal diseases; Periodontal Diseases - drug therapy; Periodontium; Prevention; Rapamycin; Regeneration; Rejuvenation; Risk factors; Sirolimus - pharmacology; Sirolimus - therapeutic use; Statistical analysis; Tooth extractions; Canada; mouse; inflammaging; cell biology; dentistry; inflammation; gum disease; aging; immunology; microbiome; rapamycin