Ventral hippocampal projections to the medial prefrontal cortex regulate social memory

• Published in: eLife Vol. 8
• Main Authors: Phillips, Mary L, Robinson, Holly Anne, Pozzo-Miller, Lucas
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 21.05.2019; eLife Sciences Publications Ltd; eLife Sciences Publications, Ltd
• Subjects: Animals; Autism; Autism Spectrum Disorder - metabolism; Autism Spectrum Disorder - pathology; Behavior; Behavior, Animal - physiology; Genotype & phenotype; Hippocampus; Hippocampus (Brain); Hippocampus - metabolism; Hippocampus - pathology; Human subjects; Humans; Innervation; Mecp2; MeCP2 protein; medial prefrontal cortex; Memory; Memory - physiology; Mental disorders; Methyl-CpG binding protein; Mice; Neurons; Neuroscience; Neurosciences; Physiological aspects; Prefrontal cortex; Prefrontal Cortex - metabolism; Prefrontal Cortex - pathology; Pyramidal cells; Pyramidal Cells - metabolism; Pyramidal Cells - pathology; Rett syndrome; Rett Syndrome - metabolism; Rett Syndrome - pathology; Rodents; social memory; Synaptic strength; Temporal Lobe - metabolism; Temporal Lobe - pathology; ventral hippocampus; United States; United States > US; Mecp2; mouse; medial prefrontal cortex; ventral hippocampus; neuroscience; Rett syndrome; autism; social memory

Inputs from the ventral hippocampus (vHIP) to the medial prefrontal cortex (mPFC) are implicated in several neuropsychiatric disorders. Here, we show that the vHIP-mPFC projection is hyperactive in the Mecp2 knockout mouse model of the autism spectrum disorder Rett syndrome, which has deficits in so...