Association of iron homeostasis-related gene polymorphisms with pregnancy and neonatal outcomes in patients with gestational diabetes mellitus

• Published in: PloS one Vol. 19; no. 12; p. e0312180
• Main Authors: Chen, Xiaoli, Huang, Huibin, Li, Juan, Zhang, Yansheng, Li, Chenmeng, Xie, Hongbin, Wang, Lingye, Wu, Qichang, Ye, Huiming
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.12.2024; Public Library of Science (PLoS)
• Subjects: Adult; Alleles; Biology and Life Sciences; Birth weight; Bone morphogenetic protein 2; Case-Control Studies; Cesarean section; Diabetes in pregnancy; Diabetes mellitus; Diabetes, Gestational - genetics; Female; Ferritin; Gene Frequency; Gene polymorphism; Genes; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease; Genetic testing; Genotype; Gestational age; Gestational diabetes; Glucose; Growth Differentiation Factor 15 - genetics; Health aspects; Hemoglobin; Homeostasis; Homeostasis - genetics; Hospitals; Humans; Hypertension; Hypoglycemia; Infant, Newborn; Infants (Newborn); Insulin resistance; Iron; Iron - metabolism; Iron in the body; Mass spectrometry; Mass spectroscopy; Medical research; Medicine and Health Sciences; Medicine, Experimental; Membrane Proteins - genetics; Metabolism; Mutation; Neonates; Newborn babies; Nucleotides; Patient outcomes; Physiological aspects; Polymorphism, Single Nucleotide; Pregnancy; Pregnancy complications; Pregnancy Outcome - genetics; Premature birth; Risk management; Risk reduction; Scientific imaging; Serine Endopeptidases; Single-nucleotide polymorphism; Womens health; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0312180

The purpose of this study was to assess associations between iron homeostasis-related gene polymorphisms and gestational diabetes mellitus (GDM), adverse pregnancy outcomes, and neonatal outcomes. In total, 138 patients with GDM and 74 normal pregnancy controls were recruited. Time-of-flight mass sp...