Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action

• Published in: eLife Vol. 6
• Main Authors: Bosch, Pablo Sanchez, Ziukaite, Ruta, Alexandre, Cyrille, Basler, Konrad, Vincent, Jean-Paul
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 04.07.2017; eLife Sciences Publications Ltd; eLife Sciences Publications, Ltd
• Subjects: Animal development; Animal wings; Animals; BMP; Body Patterning; Bone morphogenetic proteins; Cell Biology; Cellular signal transduction; Developmental Biology and Stem Cells; Drosophila; Drosophila - embryology; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Gene expression; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Genetic aspects; growth; Growth factors; Insects; Kinases; morphogen; Properties; Proteins; Spatio-Temporal Analysis; Wings, Animal - embryology; morphogen; stem cells; cell biology; BMP; developmental biology; growth; D. melanogaster

Dpp, a member of the BMP family, is a morphogen that specifies positional information in Drosophila wing precursors. In this tissue, Dpp expressed along the anterior-posterior boundary forms a concentration gradient that controls the expression domains of target genes, which in turn specify the posi...