Impact and prevention of severe exacerbations of COPD: a review of the evidence

• Published in: International journal of chronic obstructive pulmonary disease Vol. 12; pp. 2891 - 2908
• Main Authors: Halpin, David MG, Miravitlles, Marc, Metzdorf, Norbert, Celli, Bartolomé
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2017; Dove Medical Press Ltd; Dove Medical Press
• Subjects: Adrenal Cortex Hormones - therapeutic use; Analysis; Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - therapeutic use; Antibiotics; Bronchodilator Agents - therapeutic use; bronchodilators; Care and treatment; Chronic obstructive lung disease; Chronic obstructive pulmonary disease; Comorbidity; Disease Progression; Dyspnea; Emergency medical care; Epidemiology; Evidence-Based Medicine; Health aspects; Hospital Mortality; Hospitalization; Hospitals; Humans; long-acting muscarinic antagonist; Lung - drug effects; Lung - physiopathology; Mortality; Oxygen Inhalation Therapy; Patients; Physiology; Prevention; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - mortality; Pulmonary Disease, Chronic Obstructive - physiopathology; Pulmonary Disease, Chronic Obstructive - therapy; Pulmonary embolisms; Quality of Life; Recovery of Function; Respiration, Artificial; Respiratory Therapy - methods; Review; Risk Factors; Risk Reduction Behavior; severe COPD exacerbations; Time Factors; treatment; Treatment Outcome; United Kingdom > UK; United States > US; severe COPD exacerbations; treatment; hospitalization; long-acting muscarinic antagonist; bronchodilators; prevention

Severe exacerbations of COPD, ie, those leading to hospitalization, have profound clinical implications for patients and significant economic consequences for society. The prevalence and burden of severe COPD exacerbations remain high, despite recognition of the importance of exacerbation prevention...