GDF 15 as an anti-apoptotic, diagnostic and prognostic marker in oral squamous cell carcinoma

• Published in: Oral oncology Vol. 48; no. 7; pp. 608 - 614
• Main Authors: Schiegnitz, E., Kämmerer, P.W., Koch, F.P., Krüger, M., Berres, M., Al-Nawas, B.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.07.2012; Elsevier
• Subjects: Adult; Aged; Aged, 80 and over; Apoptosis; Biological and medical sciences; Biomarkers, Tumor - blood; Carcinoma, Squamous Cell - blood; Carcinoma, Squamous Cell - pathology; Case-Control Studies; Caspases - metabolism; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Female; Growth Differentiation Factor 15 - blood; Growth-differentiation factor 15 (GDF 15); Hematology, Oncology and Palliative Medicine; Humans; Male; Medical sciences; Middle Aged; Mouth Neoplasms - blood; Mouth Neoplasms - pathology; Oral squamous cell carcinoma (OSCC); Otolaryngology; Otorhinolaryngology. Stomatology; Prognosis; Serum marker; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Serum marker; Growth-differentiation factor 15 (GDF 15); Oral squamous cell carcinoma (OSCC); Prognosis; Apoptosis; Stomatology; ENT; Malignant tumor; Oral squamous cell carcinoma; Cancerology; Serum; Oral cavity disease; Diagnosis; Differentiation; Cancer; Growth factor

Growth-differentiation factor 15 (GDF 15) is involved in tumor pathogenesis and its expression is increased in many types of cancers. Functional effects of GDF 15 on oncogenesis of oral squamous cell carcinoma (OSCC) remain unclear. Therefore, the aim of this study was to examine the apoptotic chara...