A critical role of VMP1 in lipoprotein secretion

• Published in: eLife Vol. 8
• Main Authors: Morishita, Hideaki, Zhao, Yan G, Tamura, Norito, Nishimura, Taki, Kanda, Yuki, Sakamaki, Yuriko, Okazaki, Mitsuyo, Li, Dongfang, Mizushima, Noboru
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 17.09.2019; eLife Sciences Publications Ltd; eLife Sciences Publications, Ltd
• Subjects: Animals; Autophagy; autophagy-related gene; Blood lipids; Cell Biology; Cholesterol; Endoderm; Endoplasmic reticulum; Endoplasmic Reticulum - metabolism; Experiments; Genes; Intestine; Lipid bilayers; Lipids; lipoprotein; Lipoproteins; Lipoproteins - metabolism; Liver; Mammals; Membrane Proteins - deficiency; Membrane Proteins - metabolism; Mice; Nematodes; Phagocytosis; Physiological aspects; Physiology; Protein Transport; Proteins; Secretion; Software; Spinal cord; Statistical analysis; VMP1; Zebrafish; Japan; United States > US; Tokyo Japan; VMP1; mouse; cell biology; lipoprotein; autophagy-related gene; zebrafish; human; endoplasmic reticulum

Lipoproteins are lipid-protein complexes that are primarily generated and secreted from the intestine, liver, and visceral endoderm and delivered to peripheral tissues. Lipoproteins, which are assembled in the endoplasmic reticulum (ER) membrane, are released into the ER lumen for secretion, but its...