Genetic evidence for amlodipine’s protective role in gastroesophageal reflux disease: A focus on CACNB2

• Published in: PloS one Vol. 20; no. 2; p. e0309805
• Main Authors: Zhang, Liuzhao, Chu, Quanwang, Jiang, Shuyue, Shao, Bo
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.02.2025; Public Library of Science (PLoS)
• Subjects: Amlodipine; Amlodipine - pharmacology; Amlodipine - therapeutic use; Analysis; Angina pectoris; Antihypertensive drugs; Biological activity; Biology and Life Sciences; Calcium; Calcium channel blockers; Calcium channels; Calcium signalling; Calcium transport; Computer and Information Sciences; Datasets; Disease; Diseases; Dosage and administration; Drug therapy; Esophagus; Gastroesophageal reflux; Gastroesophageal Reflux - drug therapy; Gastroesophageal Reflux - genetics; Gastroesophageal Reflux - prevention & control; Gastrointestinal agents; Gene expression; Gene Regulatory Networks; Gene set enrichment analysis; Genes; Genetic analysis; Genetic aspects; Genetics; Genome-Wide Association Study; Genomes; Genomic analysis; Heterogeneity; Humans; Ion transport; Linkage analysis; Linkage disequilibrium; Medicine and Health Sciences; Mendelian Randomization Analysis; MicroRNAs; Molecular modelling; Ontology; Pathophysiology; Patient outcomes; Pharmacogenetics; Physical Sciences; Pleiotropy; Polymorphism, Single Nucleotide; Precision medicine; RNA; Sensitivity analysis; Single-nucleotide polymorphism; Software; Therapeutic targets; China

This study aims to elucidate the causal relationship between genetically predicted amlodipine use and the risk of gastroesophageal reflux disease (GERD) using a bidirectional Mendelian Randomization (MR) approach and to explore the underlying genetic and molecular mechanisms through functional enric...