Genetic evidence for amlodipine’s protective role in gastroesophageal reflux disease: A focus on CACNB2 - Zhang, Liuzhao; Chu, Quanwang; Jiang, Shuyue; Shao, Bo (PloS one, 2025)
Keywords: Amlodipine; Amlodipine - pharmacology; Amlodipine - therapeutic use; Analysis; Angina pectoris; Antihypertensive drugs; Biological activity; Biology and Life Sciences; Calcium; Calcium channel blockers; Calcium channels; Calcium signalling; Calcium transport; Computer and Information Sciences; Datasets; Disease; Diseases; Dosage and administration; Drug therapy; Esophagus; Gastroesophageal reflux; Gastroesophageal Reflux - drug therapy; Gastroesophageal Reflux - genetics; Gastroesophageal Reflux - prevention & control; Gastrointestinal agents; Gene expression; Gene Regulatory Networks; Gene set enrichment analysis; Genes; Genetic analysis; Genetic aspects; Genetics; Genome-Wide Association Study; Genomes; Genomic analysis; Heterogeneity; Humans; Ion transport; Linkage analysis; Linkage disequilibrium; Medicine and Health Sciences; Mendelian Randomization Analysis; MicroRNAs; Molecular modelling; Ontology; Pathophysiology; Patient outcomes; Pharmacogenetics; Physical Sciences; Pleiotropy; Polymorphism, Single Nucleotide; Precision medicine; RNA; Sensitivity analysis; Single-nucleotide polymorphism; Software; Therapeutic targets; China