A subcellular map of the human kinome

• Published in: eLife Vol. 10
• Main Authors: Zhang, Haitao, Cao, Xiaolei, Tang, Mei, Zhong, Guoxuan, Si, Yuan, Li, Haidong, Zhu, Feifeng, Liao, Qinghua, Li, Liuju, Zhao, Jianhui, Feng, Jia, Li, Shuaifeng, Wang, Chenliang, Kaulich, Manuel, Wang, Fangwei, Chen, Liangyi, Li, Li, Xia, Zongping, Liang, Tingbo, Lu, Huasong, Feng, Xin-Hua, Zhao, Bin
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 14.05.2021; eLife Sciences Publications Ltd; eLife Sciences Publications, Ltd
• Subjects: Antibodies; Antigenic determinants; Biochemistry and Chemical Biology; Cell Biology; Cloning; Cristae; Epitopes; Experiments; Kinases; kinome; Localization; Mitochondria; mitochondrial; MOK; Oxidative stress; phase separation; Phosphorylation; Plasma; Plasmids; Proteins; subcellular localization; Tools and Resources; cell biology; chemical biology; human; biochemistry

The human kinome comprises 538 kinases playing essential functions by catalyzing protein phosphorylation. Annotation of subcellular distribution of the kinome greatly facilitates investigation of normal and disease mechanisms. Here, we present Kinome Atlas (KA), an image-based map of the kinome anno...