Vitamin D, acute respiratory infections, and Covid-19: The curse of small-size randomised trials. A critical review with meta-analysis of randomised trials

• Published in: PloS one Vol. 20; no. 1; p. e0303316
• Main Authors: Autier, Philippe, Doi, Giulia, Mullie, Patrick, Vankrunkelsven, Patrick, D’Ecclesiis, Oriana, Gandini, Sara
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.01.2025; Public Library of Science (PLoS)
• Subjects: Alfacalcidol; Asymmetry; Bias; Calcifediol; Calciferol; Clinical trials; COVID-19; Dietary Supplements; Disease prevention; Health aspects; Humans; Intensive Care Units; Intervention; Medicine and Health Sciences; Meta-analysis; Pandemics; Patients; Physical Sciences; Prevention; Randomized Controlled Trials as Topic; Research and Analysis Methods; Respiratory tract infection; Respiratory tract infections; Respiratory Tract Infections - drug therapy; Respiratory Tract Infections - prevention & control; SARS-CoV-2; Science Policy; Vitamin D; Vitamin D - therapeutic use; Vitamins - therapeutic use; Belgium

Randomised trials conducted from 2006 to 2021 indicated that vitamin D supplementation (VDS) was able to prevent severe COVID-19 and acute respiratory infections (ARI). However, larger randomised trials published in 2022 did not confirm the health benefits of VDS in COVID-19 patients. To examine thr...