Clinical trials of disease-modifying therapies for neurodegenerative diseases: the challenges and the future

Neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease represent a crucial and exponentially increasing challenge to health care systems throughout the world. There is an urgent need for effective treatments that will both delay their onset and slow their inexorable...

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Published inNature medicine Vol. 16; no. 11; pp. 1223 - 1226
Main Author Lang, Anthony E
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.11.2010
Nature Publishing Group
Subjects
631/154/109
631/154/53
692/699/375/365
692/700/565
Alzheimer's disease
Animals
Biomedical and Life Sciences
Biomedicine
Cancer Research
Clinical trials
Clinical Trials as Topic - trends
commentary
Degeneration
Future
Health care
Humans
Infectious Diseases
Metabolic Diseases
Molecular Medicine
Nervous system
Neurodegenerative Diseases - therapy
Neurology
Neurosciences
Parkinson's disease
Terminology as Topic
Canada
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Abstract Neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease represent a crucial and exponentially increasing challenge to health care systems throughout the world. There is an urgent need for effective treatments that will both delay their onset and slow their inexorable progression. Many obstacles stand in the way of realizing these goals. It is expected that future advances will have a major impact on how and when the diagnosis will be made. It is hoped that these will eventually make it possible to initiate effective disease-modifying therapies long before the neurodegenerative process becomes established and symptomatic.
AbstractList Neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease represent a crucial and exponentially increasing challenge to health care systems throughout the world. There is an urgent need for effective treatments that will both delay their onset and slow their inexorable progression. Many obstacles stand in the way of realizing these goals. It is expected that future advances will have a major impact on how and when the diagnosis will be made. It is hoped that these will eventually make it possible to initiate effective disease-modifying therapies long before the neurodegenerative process becomes established and symptomatic. [PUBLICATION ABSTRACT]
Neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease represent a crucial and exponentially increasing challenge to health care systems throughout the world. There is an urgent need for effective treatments that will both delay their onset and slow their inexorable progression. Many obstacles stand in the way of realizing these goals. It is expected that future advances will have a major impact on how and when the diagnosis will be made. It is hoped that these will eventually make it possible to initiate effective disease-modifying therapies long before the neurodegenerative process becomes established and symptomatic.
Neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease represent a crucial and exponentially increasing challenge to health care systems throughout the world. There is an urgent need for effective treatments that will both delay their onset and slow their inexorable progression. Many obstacles stand in the way of realizing these goals. It is expected that future advances will have a major impact on how and when the diagnosis will be made. It is hoped that these will eventually make it possible to initiate effective disease-modifying therapies long before the neurodegenerative process becomes established and symptomatic.Neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease represent a crucial and exponentially increasing challenge to health care systems throughout the world. There is an urgent need for effective treatments that will both delay their onset and slow their inexorable progression. Many obstacles stand in the way of realizing these goals. It is expected that future advances will have a major impact on how and when the diagnosis will be made. It is hoped that these will eventually make it possible to initiate effective disease-modifying therapies long before the neurodegenerative process becomes established and symptomatic.
Audience Academic
Author Lang, Anthony E
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/21052078$$D View this record in MEDLINE/PubMed
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Snippet Neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease represent a crucial and exponentially increasing challenge to health care...
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SubjectTerms 631/154/109
631/154/53
692/699/375/365
692/700/565
Alzheimer's disease
Animals
Biomedical and Life Sciences
Biomedicine
Cancer Research
Clinical trials
Clinical Trials as Topic - trends
commentary
Degeneration
Future
Health care
Humans
Infectious Diseases
Metabolic Diseases
Molecular Medicine
Nervous system
Neurodegenerative Diseases - therapy
Neurology
Neurosciences
Parkinson's disease
Terminology as Topic
Title Clinical trials of disease-modifying therapies for neurodegenerative diseases: the challenges and the future
URI https://link.springer.com/article/10.1038/nm.2220
https://www.ncbi.nlm.nih.gov/pubmed/21052078
https://www.proquest.com/docview/762696697
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Volume 16
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