Epicardial electrical heterogeneity after amiodarone treatment increases vulnerability to ventricular arrhythmias under therapeutic hypothermia
Amiodarone is commonly used during therapeutic hypothermia (TH) following cardiac arrest due to ventricular arrhythmias. However, electrophysiological changes and proarrhythmic risk after amiodarone treatment have not yet been explored in TH. Epicardial high-density bi-ventricular mapping was perfor...
Saved in:
| Published in | PloS one Vol. 18; no. 4; p. e0282943 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
20.04.2023
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0282943 |
Cover
Loading…
| Abstract | Amiodarone is commonly used during therapeutic hypothermia (TH) following cardiac arrest due to ventricular arrhythmias. However, electrophysiological changes and proarrhythmic risk after amiodarone treatment have not yet been explored in TH.
Epicardial high-density bi-ventricular mapping was performed in pigs under baseline temperature (BT), TH (32-34°C), and amiodarone treatment during TH. The total activation time (TAT), conduction velocity (CV), local electrogram (LE) duration, and wavefront propagation from pre-specified segments were analyzed during sinus rhythm (SR) or right ventricular (RV) pacing (RVP), along with tissue expression of connexin 43. The vulnerability to ventricular arrhythmias was assessed.
Compared to BT, TH increased the global TAT, decreased the CV, and generated heterogeneous electrical substrate during SR and RVP. During TH, the CV reduction and LE duration prolongation were greater in the anterior mid RV than in the other areas, which changed the wavefront propagation in all animals. Compared to TH alone, amiodarone treatment during TH further increased the TAT and LE duration and decreased the CV. Heterogeneous conduction was partially attenuated after amiodarone treatment. After TH and amiodarone treatment, the connexin 43 expression in the anterior mid RV was lower than that in the other areas, compatible with the heterogeneous CV reduction. The animals under TH and amiodarone treatment had a higher incidence of inducible ventricular arrhythmias than those under BT or TH without amiodarone.
Electrical heterogeneity during amiodarone treatment and TH was associated with vulnerability to ventricular arrhythmias. |
|---|---|
| AbstractList | Background Amiodarone is commonly used during therapeutic hypothermia (TH) following cardiac arrest due to ventricular arrhythmias. However, electrophysiological changes and proarrhythmic risk after amiodarone treatment have not yet been explored in TH. Methods Epicardial high-density bi-ventricular mapping was performed in pigs under baseline temperature (BT), TH (32–34°C), and amiodarone treatment during TH. The total activation time (TAT), conduction velocity (CV), local electrogram (LE) duration, and wavefront propagation from pre-specified segments were analyzed during sinus rhythm (SR) or right ventricular (RV) pacing (RVP), along with tissue expression of connexin 43. The vulnerability to ventricular arrhythmias was assessed. Results Compared to BT, TH increased the global TAT, decreased the CV, and generated heterogeneous electrical substrate during SR and RVP. During TH, the CV reduction and LE duration prolongation were greater in the anterior mid RV than in the other areas, which changed the wavefront propagation in all animals. Compared to TH alone, amiodarone treatment during TH further increased the TAT and LE duration and decreased the CV. Heterogeneous conduction was partially attenuated after amiodarone treatment. After TH and amiodarone treatment, the connexin 43 expression in the anterior mid RV was lower than that in the other areas, compatible with the heterogeneous CV reduction. The animals under TH and amiodarone treatment had a higher incidence of inducible ventricular arrhythmias than those under BT or TH without amiodarone. Conclusion Electrical heterogeneity during amiodarone treatment and TH was associated with vulnerability to ventricular arrhythmias. Amiodarone is commonly used during therapeutic hypothermia (TH) following cardiac arrest due to ventricular arrhythmias. However, electrophysiological changes and proarrhythmic risk after amiodarone treatment have not yet been explored in TH. Epicardial high-density bi-ventricular mapping was performed in pigs under baseline temperature (BT), TH (32-34°C), and amiodarone treatment during TH. The total activation time (TAT), conduction velocity (CV), local electrogram (LE) duration, and wavefront propagation from pre-specified segments were analyzed during sinus rhythm (SR) or right ventricular (RV) pacing (RVP), along with tissue expression of connexin 43. The vulnerability to ventricular arrhythmias was assessed. Compared to BT, TH increased the global TAT, decreased the CV, and generated heterogeneous electrical substrate during SR and RVP. During TH, the CV reduction and LE duration prolongation were greater in the anterior mid RV than in the other areas, which changed the wavefront propagation in all animals. Compared to TH alone, amiodarone treatment during TH further increased the TAT and LE duration and decreased the CV. Heterogeneous conduction was partially attenuated after amiodarone treatment. After TH and amiodarone treatment, the connexin 43 expression in the anterior mid RV was lower than that in the other areas, compatible with the heterogeneous CV reduction. The animals under TH and amiodarone treatment had a higher incidence of inducible ventricular arrhythmias than those under BT or TH without amiodarone. Electrical heterogeneity during amiodarone treatment and TH was associated with vulnerability to ventricular arrhythmias. Background Amiodarone is commonly used during therapeutic hypothermia (TH) following cardiac arrest due to ventricular arrhythmias. However, electrophysiological changes and proarrhythmic risk after amiodarone treatment have not yet been explored in TH. Methods Epicardial high-density bi-ventricular mapping was performed in pigs under baseline temperature (BT), TH (32–34°C), and amiodarone treatment during TH. The total activation time (TAT), conduction velocity (CV), local electrogram (LE) duration, and wavefront propagation from pre-specified segments were analyzed during sinus rhythm (SR) or right ventricular (RV) pacing (RVP), along with tissue expression of connexin 43. The vulnerability to ventricular arrhythmias was assessed. Results Compared to BT, TH increased the global TAT, decreased the CV, and generated heterogeneous electrical substrate during SR and RVP. During TH, the CV reduction and LE duration prolongation were greater in the anterior mid RV than in the other areas, which changed the wavefront propagation in all animals. Compared to TH alone, amiodarone treatment during TH further increased the TAT and LE duration and decreased the CV. Heterogeneous conduction was partially attenuated after amiodarone treatment. After TH and amiodarone treatment, the connexin 43 expression in the anterior mid RV was lower than that in the other areas, compatible with the heterogeneous CV reduction. The animals under TH and amiodarone treatment had a higher incidence of inducible ventricular arrhythmias than those under BT or TH without amiodarone. Conclusion Electrical heterogeneity during amiodarone treatment and TH was associated with vulnerability to ventricular arrhythmias. Amiodarone is commonly used during therapeutic hypothermia (TH) following cardiac arrest due to ventricular arrhythmias. However, electrophysiological changes and proarrhythmic risk after amiodarone treatment have not yet been explored in TH.BACKGROUNDAmiodarone is commonly used during therapeutic hypothermia (TH) following cardiac arrest due to ventricular arrhythmias. However, electrophysiological changes and proarrhythmic risk after amiodarone treatment have not yet been explored in TH.Epicardial high-density bi-ventricular mapping was performed in pigs under baseline temperature (BT), TH (32-34°C), and amiodarone treatment during TH. The total activation time (TAT), conduction velocity (CV), local electrogram (LE) duration, and wavefront propagation from pre-specified segments were analyzed during sinus rhythm (SR) or right ventricular (RV) pacing (RVP), along with tissue expression of connexin 43. The vulnerability to ventricular arrhythmias was assessed.METHODSEpicardial high-density bi-ventricular mapping was performed in pigs under baseline temperature (BT), TH (32-34°C), and amiodarone treatment during TH. The total activation time (TAT), conduction velocity (CV), local electrogram (LE) duration, and wavefront propagation from pre-specified segments were analyzed during sinus rhythm (SR) or right ventricular (RV) pacing (RVP), along with tissue expression of connexin 43. The vulnerability to ventricular arrhythmias was assessed.Compared to BT, TH increased the global TAT, decreased the CV, and generated heterogeneous electrical substrate during SR and RVP. During TH, the CV reduction and LE duration prolongation were greater in the anterior mid RV than in the other areas, which changed the wavefront propagation in all animals. Compared to TH alone, amiodarone treatment during TH further increased the TAT and LE duration and decreased the CV. Heterogeneous conduction was partially attenuated after amiodarone treatment. After TH and amiodarone treatment, the connexin 43 expression in the anterior mid RV was lower than that in the other areas, compatible with the heterogeneous CV reduction. The animals under TH and amiodarone treatment had a higher incidence of inducible ventricular arrhythmias than those under BT or TH without amiodarone.RESULTSCompared to BT, TH increased the global TAT, decreased the CV, and generated heterogeneous electrical substrate during SR and RVP. During TH, the CV reduction and LE duration prolongation were greater in the anterior mid RV than in the other areas, which changed the wavefront propagation in all animals. Compared to TH alone, amiodarone treatment during TH further increased the TAT and LE duration and decreased the CV. Heterogeneous conduction was partially attenuated after amiodarone treatment. After TH and amiodarone treatment, the connexin 43 expression in the anterior mid RV was lower than that in the other areas, compatible with the heterogeneous CV reduction. The animals under TH and amiodarone treatment had a higher incidence of inducible ventricular arrhythmias than those under BT or TH without amiodarone.Electrical heterogeneity during amiodarone treatment and TH was associated with vulnerability to ventricular arrhythmias.CONCLUSIONElectrical heterogeneity during amiodarone treatment and TH was associated with vulnerability to ventricular arrhythmias. Amiodarone is commonly used during therapeutic hypothermia (TH) following cardiac arrest due to ventricular arrhythmias. However, electrophysiological changes and proarrhythmic risk after amiodarone treatment have not yet been explored in TH. Epicardial high-density bi-ventricular mapping was performed in pigs under baseline temperature (BT), TH (32-34°C), and amiodarone treatment during TH. The total activation time (TAT), conduction velocity (CV), local electrogram (LE) duration, and wavefront propagation from pre-specified segments were analyzed during sinus rhythm (SR) or right ventricular (RV) pacing (RVP), along with tissue expression of connexin 43. The vulnerability to ventricular arrhythmias was assessed. Compared to BT, TH increased the global TAT, decreased the CV, and generated heterogeneous electrical substrate during SR and RVP. During TH, the CV reduction and LE duration prolongation were greater in the anterior mid RV than in the other areas, which changed the wavefront propagation in all animals. Compared to TH alone, amiodarone treatment during TH further increased the TAT and LE duration and decreased the CV. Heterogeneous conduction was partially attenuated after amiodarone treatment. After TH and amiodarone treatment, the connexin 43 expression in the anterior mid RV was lower than that in the other areas, compatible with the heterogeneous CV reduction. The animals under TH and amiodarone treatment had a higher incidence of inducible ventricular arrhythmias than those under BT or TH without amiodarone. Electrical heterogeneity during amiodarone treatment and TH was associated with vulnerability to ventricular arrhythmias. |
| Audience | Academic |
| Author | Lo, Li-Wei Chao, Tze-Fan Chen, Yi-Jen Chang, Ting-Yung Tuan, Ta-Chuan Lin, Chin-Yu Liao, Jo-Nan Hu, Yu-Feng Hsieh, Yu-Cheng Lin, Yenn-Jiang Yeh, Hung-I Chung, Fa-Po Chang, Shih-Lin Chen, Shih-Ann |
| AuthorAffiliation | 2 Department of Heart Rhythm Center, Taipei Veterans General Hospital, Taipei, Taiwan 3 Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan 6 Department of Medicine, Mackay Medical College, Taipei, Taiwan 5 Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan 7 Department of Medicine, National Chung Hsing University, Taichung, Taiwan Ohio State University, UNITED STATES 1 Department of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan 4 Department of Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan |
| AuthorAffiliation_xml | – name: 6 Department of Medicine, Mackay Medical College, Taipei, Taiwan – name: Ohio State University, UNITED STATES – name: 3 Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan – name: 7 Department of Medicine, National Chung Hsing University, Taichung, Taiwan – name: 5 Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan – name: 1 Department of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan – name: 2 Department of Heart Rhythm Center, Taipei Veterans General Hospital, Taipei, Taiwan – name: 4 Department of Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan |
| Author_xml | – sequence: 1 givenname: Chin-Yu orcidid: 0000-0003-3282-7523 surname: Lin fullname: Lin, Chin-Yu – sequence: 2 givenname: Ting-Yung surname: Chang fullname: Chang, Ting-Yung – sequence: 3 givenname: Yu-Feng orcidid: 0000-0001-5715-2070 surname: Hu fullname: Hu, Yu-Feng – sequence: 4 givenname: Yu-Cheng surname: Hsieh fullname: Hsieh, Yu-Cheng – sequence: 5 givenname: Yi-Jen surname: Chen fullname: Chen, Yi-Jen – sequence: 6 givenname: Hung-I surname: Yeh fullname: Yeh, Hung-I – sequence: 7 givenname: Yenn-Jiang surname: Lin fullname: Lin, Yenn-Jiang – sequence: 8 givenname: Shih-Lin surname: Chang fullname: Chang, Shih-Lin – sequence: 9 givenname: Li-Wei surname: Lo fullname: Lo, Li-Wei – sequence: 10 givenname: Tze-Fan surname: Chao fullname: Chao, Tze-Fan – sequence: 11 givenname: Fa-Po surname: Chung fullname: Chung, Fa-Po – sequence: 12 givenname: Jo-Nan surname: Liao fullname: Liao, Jo-Nan – sequence: 13 givenname: Ta-Chuan surname: Tuan fullname: Tuan, Ta-Chuan – sequence: 14 givenname: Shih-Ann surname: Chen fullname: Chen, Shih-Ann |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37079563$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNk81q3DAQx01JaT7aNyitoVDaw24lyytZpxJC2gYCgX5dhSyP11pkayPJofsUfeWOu5uwW3IoPlgz85v_jIbRaXY0-AGy7CUlc8oE_bDyYxi0m6_RPSdFVciSPclOqGTFjBeEHe2dj7PTGFeELFjF-bPsmAki5IKzk-z35doaHRqrXQ4OTApouryDBMEvYQCbNrlu0cp1b32jA5bLUwCdehhSbgeD5wgxvxvdAEHX1k0pyed3GEe10WnMDaHbpK63Oubj0KBa6hBew5isybvN2k82hp9nT1vtIrzY_c-yH58uv198mV3ffL66OL-eGV4WacYWRQ2sMrwVutZ1KWgFCymo5I0wpKmaRWFkC1wS4KQ2UhMtjJCMt02JJGFn2eut7tr5qHazjKqoCKskk4whcbUlGq9Xah1sr8NGeW3VX4cPS6UDdu9AESoAtGmbQshywclUrioL3dbUEAEGtT7uqo11D42ZJqPdgehhZLCdWvo7RQmlFeUCFd7tFIK_HSEm1dtowDk9gB-3jUteUjE1_uYf9PHr7ailxhvYofVY2Eyi6lyUHDeM8BKp-SMUfg301uAqtBb9BwnvDxKQSfArLfUYo7r69vX_2Zufh-zbPbYD7VIXvcP18UM8BF_tj_phxvcrj0C5BUzwMQZoHxBK1PSy7selppeldi-L_QH9sBnt |
| Cites_doi | 10.1161/CIRCEP.110.960658 10.1161/01.CIR.91.2.451 10.1053/j.jvca.2012.11.026 10.1056/NEJMoa003289 10.1016/j.hrthm.2009.04.030 10.1016/S0735-1097(98)00330-1 10.1016/j.hrthm.2015.07.030 10.1161/CIRCEP.113.000833 10.1016/S0008-6363(97)00114-4 10.1016/S0735-1097(85)80272-2 10.1152/physrev.00025.2003 10.1161/01.CIR.78.3.684 10.1161/hc0402.102975 10.1253/circj.CJ-10-1001 10.1016/j.jacc.2005.12.049 10.1161/01.CIR.100.19.2025 10.1016/S0092-8674(01)00243-4 10.1093/europace/eup233 10.1016/j.hrthm.2010.10.044 10.1097/00005344-199909000-00019 10.1056/NEJMoa012689 10.1152/ajpheart.00079.2007 10.1016/j.cardiores.2003.09.016 10.1161/CIR.0000000000000262 10.1093/cvr/cvz309 10.1016/S0002-9149(97)00717-0 10.1161/CIRCULATIONAHA.119.042423 10.1016/S0735-1097(86)80273-X 10.1097/00005344-199407000-00020 10.1038/s41467-022-28418-1 10.1161/JAHA.117.006472 10.1016/0002-8703(84)90451-4 10.1097/00005344-199012000-00006 10.1016/j.hrthm.2017.08.016 10.1016/j.hrthm.2011.11.046 10.1161/JAHA.120.016676 10.1093/cvr/cvy305 10.1136/hrt.63.6.342 |
| ContentType | Journal Article |
| Copyright | Copyright: © 2023 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. COPYRIGHT 2023 Public Library of Science 2023 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2023 Lin et al 2023 Lin et al 2023 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: Copyright: © 2023 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. – notice: COPYRIGHT 2023 Public Library of Science – notice: 2023 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2023 Lin et al 2023 Lin et al – notice: 2023 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0282943 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection ProQuest - Health & Medical Complete保健、医学与药学数据库 ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition Engineering collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Agricultural Science Database MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals (DOAJ) url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| DocumentTitleAlternate | Amiodarone and hypothermia increase heterogeneity |
| EISSN | 1932-6203 |
| ExternalDocumentID | 2803893933 oai_doaj_org_article_017eeacfd27945609a0a842afb1c07ec PMC10118167 A746371064 37079563 10_1371_journal_pone_0282943 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Taiwan |
| GeographicLocations_xml | – name: Taiwan |
| GrantInformation_xml | – fundername: ; grantid: 109-2314-B-075 -076 -MY3, 111-2314-B-075 -007 -MY3 |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV AEAQA AENEX AEUYN AFKRA AFPKN AFRAH AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM 3V. ADRAZ BBORY CGR CUY CVF ECM EIF IPNFZ NPM RIG PMFND 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI RC3 7X8 PUEGO 5PM AAPBV ABPTK N95 |
| ID | FETCH-LOGICAL-c642t-352be38c6f7abab4718e597196d7c0d8d52c9fe690e60bc9a0a7c7936fd48e503 |
| IEDL.DBID | M48 |
| ISSN | 1932-6203 |
| IngestDate | Sun Jun 04 06:37:13 EDT 2023 Wed Aug 27 01:26:32 EDT 2025 Thu Aug 21 18:38:32 EDT 2025 Fri Sep 05 00:17:28 EDT 2025 Fri Jul 25 11:29:00 EDT 2025 Tue Jun 17 20:47:32 EDT 2025 Tue Jun 10 20:49:03 EDT 2025 Fri Jun 27 05:40:23 EDT 2025 Fri Jun 27 05:49:12 EDT 2025 Thu May 22 21:15:02 EDT 2025 Wed Feb 19 02:23:55 EST 2025 Tue Jul 01 02:50:14 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| License | Copyright: © 2023 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c642t-352be38c6f7abab4718e597196d7c0d8d52c9fe690e60bc9a0a7c7936fd48e503 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. |
| ORCID | 0000-0003-3282-7523 0000-0001-5715-2070 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pone.0282943 |
| PMID | 37079563 |
| PQID | 2803893933 |
| PQPubID | 1436336 |
| PageCount | e0282943 |
| ParticipantIDs | plos_journals_2803893933 doaj_primary_oai_doaj_org_article_017eeacfd27945609a0a842afb1c07ec pubmedcentral_primary_oai_pubmedcentral_nih_gov_10118167 proquest_miscellaneous_2803964173 proquest_journals_2803893933 gale_infotracmisc_A746371064 gale_infotracacademiconefile_A746371064 gale_incontextgauss_ISR_A746371064 gale_incontextgauss_IOV_A746371064 gale_healthsolutions_A746371064 pubmed_primary_37079563 crossref_primary_10_1371_journal_pone_0282943 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2023-04-20 |
| PublicationDateYYYYMMDD | 2023-04-20 |
| PublicationDate_xml | – month: 04 year: 2023 text: 2023-04-20 day: 20 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2023 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | FG Akar (pone.0282943.ref036) 2007; 293 JN Nanas (pone.0282943.ref033) 1995; 91 ES Dietrichs (pone.0282943.ref037) 2020; 116 JH Levine (pone.0282943.ref011) 1988; 78 F Morady (pone.0282943.ref032) 1986; 7 XK Fu (pone.0282943.ref005) 2020; 36 N Ikeda (pone.0282943.ref031) 1984; 108 CP Day (pone.0282943.ref022) 1990; 63 EM Aliot (pone.0282943.ref026) 2009; 6 JS Piktel (pone.0282943.ref004) 2021; 10 JS Piktel (pone.0282943.ref029) 2017; 6 D Izumi (pone.0282943.ref041) 2012; 9 CT Wass (pone.0282943.ref019) 2013; 27 F Morady (pone.0282943.ref034) 1985; 6 ES Dietrichs (pone.0282943.ref013) 2019; 115 MD Cerqueira (pone.0282943.ref028) 2002; 105 R Panikkath (pone.0282943.ref030) 2011; 4 M El Haddad (pone.0282943.ref024) 2014; 7 K Kelemen (pone.0282943.ref039) 2022; 13 J Castro Hevia (pone.0282943.ref023) 2006; 47 E Chavez-Gonzalez (pone.0282943.ref021) 2017; 41 E Drouin (pone.0282943.ref038) 1998; 32 SA Bernard (pone.0282943.ref002) 2002; 346 JN Khan (pone.0282943.ref016) 2009; 11 CM Tschabrunn (pone.0282943.ref017) 2016; 13 E Coraboeuf (pone.0282943.ref006) 1998; 182 RA Quinteiro (pone.0282943.ref010) 1994; 24 SJ Connolly (pone.0282943.ref012) 1999; 100 ML Riess (pone.0282943.ref008) 2004; 61 I Kodama (pone.0282943.ref009) 1997; 35 AG Kleber (pone.0282943.ref035) 2004; 84 YC Hsieh (pone.0282943.ref007) 2011; 75 MT Keating (pone.0282943.ref040) 2001; 104 Z Aziz (pone.0282943.ref025) 2019; 140 R Tung (pone.0282943.ref018) 2011; 8 CW Callaway (pone.0282943.ref001) 2015; 132 SH Hohnloser (pone.0282943.ref015) 1997; 80 (pone.0282943.ref003) 2002; 346 E Winslow (pone.0282943.ref014) 1990; 16 L Zhou (pone.0282943.ref020) 1999; 34 M Masuda (pone.0282943.ref027) 2017; 14 |
| References_xml | – volume: 4 start-page: 441 year: 2011 ident: pone.0282943.ref030 article-title: Prolonged Tpeak-to-tend interval on the resting ECG is associated with increased risk of sudden cardiac death. publication-title: Circ Arrhythm Electrophysiol doi: 10.1161/CIRCEP.110.960658 – volume: 91 start-page: 451 year: 1995 ident: pone.0282943.ref033 article-title: Pharmacokinetics and regional electrophysiological effects of intracoronary amiodarone administration publication-title: Circulation doi: 10.1161/01.CIR.91.2.451 – volume: 27 start-page: 288 year: 2013 ident: pone.0282943.ref019 article-title: Therapeutic hypothermia for out-of-hospital ventricular fibrillation survivors: a feasibility study comparing time to achieve target core temperature using conventional conductive cooling versus combined conductive plus pericranial convective cooling. publication-title: J Cardiothorac Vasc Anesth doi: 10.1053/j.jvca.2012.11.026 – volume: 346 start-page: 557 year: 2002 ident: pone.0282943.ref002 article-title: Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia publication-title: N Engl J Med doi: 10.1056/NEJMoa003289 – volume: 6 start-page: 886 year: 2009 ident: pone.0282943.ref026 article-title: EHRA/HRS Expert Consensus on Catheter Ablation of Ventricular Arrhythmias: developed in a partnership with the European Heart Rhythm Association (EHRA), a Registered Branch of the European Society of Cardiology (ESC), and the Heart Rhythm Society (HRS); in collaboration with the American College of Cardiology (ACC) and the American Heart Association (AHA). publication-title: Heart Rhythm. doi: 10.1016/j.hrthm.2009.04.030 – volume: 32 start-page: 1063 year: 1998 ident: pone.0282943.ref038 article-title: Amiodarone reduces transmural heterogeneity of repolarization in the human heart publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(98)00330-1 – volume: 13 start-page: 262 year: 2016 ident: pone.0282943.ref017 article-title: A swine model of infarct-related reentrant ventricular tachycardia: Electroanatomic, magnetic resonance, and histopathological characterization publication-title: Heart Rhythm doi: 10.1016/j.hrthm.2015.07.030 – volume: 7 start-page: 463 year: 2014 ident: pone.0282943.ref024 article-title: Novel algorithmic methods in mapping of atrial and ventricular tachycardia. publication-title: Circ Arrhythm Electrophysiol doi: 10.1161/CIRCEP.113.000833 – volume: 35 start-page: 13 year: 1997 ident: pone.0282943.ref009 article-title: Cellular electropharmacology of amiodarone publication-title: Cardiovasc Res doi: 10.1016/S0008-6363(97)00114-4 – volume: 6 start-page: 179 year: 1985 ident: pone.0282943.ref034 article-title: Rate-dependent effects of intravenous lidocaine, procainamide and amiodarone on intraventricular conduction publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(85)80272-2 – volume: 84 start-page: 431 year: 2004 ident: pone.0282943.ref035 article-title: Basic mechanisms of cardiac impulse propagation and associated arrhythmias publication-title: Physiol Rev doi: 10.1152/physrev.00025.2003 – volume: 78 start-page: 684 year: 1988 ident: pone.0282943.ref011 article-title: Mechanisms of depressed conduction from long-term amiodarone therapy in canine myocardium publication-title: Circulation doi: 10.1161/01.CIR.78.3.684 – volume: 105 start-page: 539 year: 2002 ident: pone.0282943.ref028 article-title: Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association publication-title: Circulation doi: 10.1161/hc0402.102975 – volume: 75 start-page: 1706 year: 2011 ident: pone.0282943.ref007 article-title: Short-duration therapeutic hypothermia causes prompt connexin43 gap junction remodeling in isolated rabbit hearts. publication-title: Circ J doi: 10.1253/circj.CJ-10-1001 – volume: 47 start-page: 1828 year: 2006 ident: pone.0282943.ref023 article-title: Tpeak-Tend and Tpeak-Tend dispersion as risk factors for ventricular tachycardia/ventricular fibrillation in patients with the Brugada syndrome publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2005.12.049 – volume: 100 start-page: 2025 year: 1999 ident: pone.0282943.ref012 article-title: Evidence-based analysis of amiodarone efficacy and safety publication-title: Circulation doi: 10.1161/01.CIR.100.19.2025 – volume: 104 start-page: 569 year: 2001 ident: pone.0282943.ref040 article-title: Molecular and cellular mechanisms of cardiac arrhythmias publication-title: Cell doi: 10.1016/S0092-8674(01)00243-4 – volume: 11 start-page: 1566 year: 2009 ident: pone.0282943.ref016 article-title: Amiodarone use in therapeutic hypothermia following cardiac arrest due to ventricular tachycardia and ventricular fibrillation. publication-title: Europace. doi: 10.1093/europace/eup233 – volume: 8 start-page: 439 year: 2011 ident: pone.0282943.ref018 article-title: Accuracy of combined endocardial and epicardial electroanatomic mapping of a reperfused porcine infarct model: a comparison of electrofield and magnetic systems with histopathologic correlation publication-title: Heart Rhythm doi: 10.1016/j.hrthm.2010.10.044 – volume: 34 start-page: 440 year: 1999 ident: pone.0282943.ref020 article-title: A comparison of the antifibrillatory effects of desethylamiodarone to amiodarone in a swine model publication-title: J Cardiovasc Pharmacol doi: 10.1097/00005344-199909000-00019 – volume: 346 start-page: 549 year: 2002 ident: pone.0282943.ref003 article-title: Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. publication-title: N Engl J Med doi: 10.1056/NEJMoa012689 – volume: 293 start-page: H1223 year: 2007 ident: pone.0282943.ref036 article-title: Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00079.2007 – volume: 61 start-page: 580 year: 2004 ident: pone.0282943.ref008 article-title: Reduced reactive O2 species formation and preserved mitochondrial NADH and [Ca2+] levels during short-term 17 degrees C ischemia in intact hearts publication-title: Cardiovasc Res doi: 10.1016/j.cardiores.2003.09.016 – volume: 41 start-page: 347 year: 2017 ident: pone.0282943.ref021 article-title: QRS duration and dispersion for predicting ventricular arrhythmias in early stage of acute myocardial infraction. publication-title: Med Intensiva – volume: 132 start-page: S465 year: 2015 ident: pone.0282943.ref001 article-title: Part 8: Post-Cardiac Arrest Care: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care publication-title: Circulation doi: 10.1161/CIR.0000000000000262 – volume: 116 start-page: 2081 year: 2020 ident: pone.0282943.ref037 article-title: Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology publication-title: Cardiovasc Res doi: 10.1093/cvr/cvz309 – volume: 80 start-page: 82G year: 1997 ident: pone.0282943.ref015 article-title: Proarrhythmia with class III antiarrhythmic drugs: types, risks, and management. publication-title: Am J Cardiol doi: 10.1016/S0002-9149(97)00717-0 – volume: 140 start-page: 1383 year: 2019 ident: pone.0282943.ref025 article-title: Targeted Ablation of Ventricular Tachycardia Guided by Wavefront Discontinuities During Sinus Rhythm: A New Functional Substrate Mapping Strategy publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.119.042423 – volume: 7 start-page: 148 year: 1986 ident: pone.0282943.ref032 article-title: Acute and chronic effects of amiodarone on ventricular refractoriness, intraventricular conduction and ventricular tachycardia induction publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(86)80273-X – volume: 24 start-page: 122 year: 1994 ident: pone.0282943.ref010 article-title: Chronic versus acute effects of amiodarone on the Vmax-conduction velocity relationship and on the space constant in canine myocardium publication-title: J Cardiovasc Pharmacol doi: 10.1097/00005344-199407000-00020 – volume: 13 start-page: 830 year: 2022 ident: pone.0282943.ref039 article-title: Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar. publication-title: Nat Commun doi: 10.1038/s41467-022-28418-1 – volume: 6 year: 2017 ident: pone.0282943.ref029 article-title: Hypothermia Modulates Arrhythmia Substrates During Different Phases of Resuscitation From Ischemic Cardiac Arrest publication-title: J Am Heart Assoc doi: 10.1161/JAHA.117.006472 – volume: 108 start-page: 890 year: 1984 ident: pone.0282943.ref031 article-title: Electrophysiologic effects of amiodarone: experimental and clinical observation relative to serum and tissue drug concentrations publication-title: Am Heart J doi: 10.1016/0002-8703(84)90451-4 – volume: 16 start-page: 896 year: 1990 ident: pone.0282943.ref014 article-title: Effects of amiodarone on cardiac electrophysiology and inducibility of arrhythmias in chronically infarcted dogs: late arrhythmias, haemodynamics, and sympatholytic actions publication-title: J Cardiovasc Pharmacol doi: 10.1097/00005344-199012000-00006 – volume: 14 start-page: 1606 year: 2017 ident: pone.0282943.ref027 article-title: The identification of conduction gaps after pulmonary vein isolation using a new electroanatomic mapping system publication-title: Heart Rhythm doi: 10.1016/j.hrthm.2017.08.016 – volume: 9 start-page: 796 year: 2012 ident: pone.0282943.ref041 article-title: The peak-to-end of the T wave in the limb ECG leads reflects total spatial rather than transmural dispersion of ventricular repolarization in an anthopleurin-A model of prolonged QT interval publication-title: Heart Rhythm doi: 10.1016/j.hrthm.2011.11.046 – volume: 10 start-page: e016676 year: 2021 ident: pone.0282943.ref004 article-title: Effect of Amiodarone and Hypothermia on Arrhythmia Substrates During Resuscitation publication-title: J Am Heart Assoc doi: 10.1161/JAHA.120.016676 – volume: 115 start-page: 501 year: 2019 ident: pone.0282943.ref013 article-title: Hypothermia and cardiac electrophysiology: a systematic review of clinical and experimental data publication-title: Cardiovasc Res doi: 10.1093/cvr/cvy305 – volume: 63 start-page: 342 year: 1990 ident: pone.0282943.ref022 article-title: QT dispersion: an indication of arrhythmia risk in patients with long QT intervals publication-title: Br Heart J doi: 10.1136/hrt.63.6.342 – volume: 182 start-page: 325 year: 1998 ident: pone.0282943.ref006 article-title: Transient outward potassium current and repolarization of cardiac cells publication-title: Bull Acad Natl Med – volume: 36 start-page: 228 year: 2020 ident: pone.0282943.ref005 article-title: Effects of hypothermia on the repolarization duration of ventricular myocytes in rats and its mechanism publication-title: Zhongguo Ying Yong Sheng Li Xue Za Zhi |
| SSID | ssj0053866 |
| Score | 2.416223 |
| Snippet | Amiodarone is commonly used during therapeutic hypothermia (TH) following cardiac arrest due to ventricular arrhythmias. However, electrophysiological changes... Background Amiodarone is commonly used during therapeutic hypothermia (TH) following cardiac arrest due to ventricular arrhythmias. However,... Background Amiodarone is commonly used during therapeutic hypothermia (TH) following cardiac arrest due to ventricular arrhythmias. However,... |
| SourceID | plos doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database |
| StartPage | e0282943 |
| SubjectTerms | Amiodarone Amiodarone - adverse effects Analysis Animals Arrhythmia Arrhythmias, Cardiac Biology and Life Sciences Cardiac arrest Cardiac arrhythmia Catheters Conduction Connexin 43 Connexin 43 - metabolism Diagnosis Electrocardiography Geometry Health aspects Heart Heart Ventricles Heterogeneity Hogs Hypothermia Hypothermia, Induced - adverse effects Laboratory animals Medicine and Health Sciences Morphology Ostomy Potassium Prolongation Reduction Research and Analysis Methods Risk factors Sinuses Substrates Swine Ventricle Wave fronts Wave propagation |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELbQnrggyqsLCxiEBBzSZvNwkmNBrQoSIAFFvVl-pVlpm0RJFml_BX-ZGdsbbVAlOHDNzDremW_smXhmTMirWIZS5pIFaaoEluQUgSghWDG5Ae9cx0oLDBQ_fWbnF8nHy_Ry76ovzAlz7YGd4I4BMQYWh1JHgBzYngsRijyJRCmXKsyMwtUX9rxdMOXWYLBixnyhXJwtj71ejtqmNkf28DCJJxuR7dc_rsqzdt30N7mcf2ZO7m1FZ3fJHe9D0hM39wNyy9T3yIG30p6-8a2k394nv05bUAJiYE3dhTeoE1phDkwD0DHgg1N7TTgV16tGiw6mTsfkc7qq0ansYdCfmzUOalNpt3RoKOZJ2o-HAn7bddV2qK5XoqdYlNbRvbIuWm1bW-YF5Afk4uz0-_vzwF_BECgITIYA3DNp4lyxMhNSSNzJDIQgYLY6U6HOdRqpojQQYhsWSoXKyRSYPCt1Apxh_JDMapj5IaEClC8hOhQlSxOpc5EIHac6zVkYlywycxLs9MFb12mD2-O2DCIUJ1iO-uNef3PyDpU28mKfbPsA0MM9evjf0DMnz1Hl3BWdjtbOT7KEwYvBX5uTl5YDe2XUmIxzJTZ9zz98-fEPTN--Tphee6ayAfAo4Qsg4D9hD64J52LCCRavJuRDBOhOKj3HG8bA7yxiEMpiB9qbyS9GMg6KCXa1aTaOp2DJMgOeRw7jo2Rj7KKYMqDkE_RPRD-l1KvKtipf2sJmlj3-H8p6Qm5H4GLiWV4ULshs6DbmKbiEg3xmrf835ZplaA priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjR3LbtQw0ILthQuivLqlgEFIwCFtNg8ne0It2qogUVChqDfLrzQrbZOQZJH2K_hlZhwnNKhCXDMTx_E8PGPPg5BXofSlTCXz4lgJTMmZeyIDZ8WkBqxzHSot0FH8dMpOzqOPF_GFO3BrXFhlrxOtotalwjPyA-yiBHsr-N_vqh8edo3C21XXQuM22QIVnMYTsnW0OP1y1utikGbGXMJcmMwOHH32q7Iw-_YSMQpHG5Kt2z9o50m1KpubTM-_IyivbUnH98hdZ0vSw4742-SWKe6TbSetDX3jSkq_fUB-LSogBvLCinaNb5A2NMdYmBJYyIAtTm27cCqulqUWNUydDkHodFmgcdnAoD_XKxzUhtRuaFtSjJe0h4gC3q3rfNPmV0vRUExOq-m19C6abyqb7gXgh-T8ePHt_YnnWjF4ChyU1gMzTZowVSxLhBQSdzQDrgiIr06Ur1MdB2qeGXC1DfOlmgtfJApEn2U6Akw_fEQmBcx8h1ABTCDBSxQZiyOpUxEJHcY6TpkfZiwwU-L19OBVV3GD22u3BDyVbmE50o87-k3JERJtwMV62fZBWV9yJ34c9I6BLSbTAegfMPJwgmkUiEzOlJ8YNSXPkeS8Sz4dpJ4fJhGDD4PdNiUvLQbWzCgwKOdSrJuGf_j8_T-Qvp6NkF47pKwE5lHCJULAP2EtrhHm3ggTJF-NwDvIoP2qNPyPjMCbPdPeDH4xgHFQDLQrTLnucOYsmiWA87jj8WFlQ6ymGDOApCPuHy39GFIsc1uyfGYTnFmy--95PSF3AjAi8bYu8PfIpK3X5ikYfa185iT7N-bvXZc priority: 102 providerName: ProQuest |
| Title | Epicardial electrical heterogeneity after amiodarone treatment increases vulnerability to ventricular arrhythmias under therapeutic hypothermia |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/37079563 https://www.proquest.com/docview/2803893933 https://www.proquest.com/docview/2803964173 https://pubmed.ncbi.nlm.nih.gov/PMC10118167 https://doaj.org/article/017eeacfd27945609a0a842afb1c07ec http://dx.doi.org/10.1371/journal.pone.0282943 |
| Volume | 18 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9NAEF616YULoryaEsKCkICDIz93nQNCbZVQkFpQISg3a19uIqV2sBNEfgV_mZm1Y9UoSL34kB2vnZnZ2W-88yDkdSBdKWPJnChSAlNyho5IwVkxsQF0rgOlBTqKF5fsfBJ-nkbTPbLt2VozsNzp2mE_qUmxGPz-ufkAC_697drAve1Ng2WemYE9GgyDfXIAexNDPb8Im3MFWN329BJRi8N8N6iT6f43S2uzsjX9G8vdWS7ychcs_Te68tZ2NX5A7tc4k55UinFI9kz2kBzWK7mkb-ty0-8ekT-jJQgK9WRBq6Y4KDc6wziZHNTLAE6ntpU4FTfzXIsCXp02Aep0niHwLGHSX-sFTmrDbTd0lVOMpbQfGAXcWxSzzWp2MxclxcS1gt5K_aKzzdKmgsHwYzIZj76fnTt1mwZHgfOycgDCSRPEiqVcSCFxtzPgpsDS1ly5OtaRr4apATfcMFeqoXAFV2AWWKpDoHSDJ6STwZsfESpAQSR4kCJlUSh1LEKhg0hHMXODlPmmS5ytPJJlVY0jsUdyHLyYirEJyi-p5dclpyi0hhZradsf8uI6qZdmAjbJwPaTah9sEwBAfME49EUqPeVyo7rkBYo8qRJTG4uQnPCQwYMB03XJK0uB9TQyDNi5FuuyTD59-XEHom9XLaI3NVGag_IoUSdJwH_COl0tyl6LEqyCag0foYJuuVIm2IUMsOkwAKb0tkq7e_hlM4yTYhBeZvJ1RTNkoceB5mml4w1nA6y0GDEYiVva32J9eySbz2w5c88mPzN-fIcHPyP3fECZeJznuz3SWRVr8xxQ4Ur2yT6fcrjGZx5exx_75OB0dPn1qm-_s_StIfgLe-FrEA |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6VcIALorwaKHRBIODg1vFj7RwQKtDQ0AcStKi3ZV9uIqW2sRNQfgX_hN_IzPpBjSrEpdfMeLPe-XZ2xjsPQp760pUylswJQyUwJWfoiAScFRMbsM61r7RAR_HgkO0eBx9OwpMV8qvJhcGwykYnWkWtM4XfyLewixKcreB_v86_Odg1Cm9XmxYaFSz2zPIHuGzlq_E7kO8zzxvtHL3ddequAo4CW3vugMUhjR8rlkRCConK2YBVDUjUkXJ1rENPDRMDXqNhrlRD4YpIAYpZogPgdH0Y9wq5iq-Ftfrj0ftG84PuYKxOz_OjwVaNhs08S82mvbIM_M7xZ7sEtGdBL59l5UWG7t_xmucOwNFNcqO2XOl2BbVVsmLSW2S11g0lfVEXsH55m_zcyUH0iLwZrdrsIBLoBCNvMgCsAcuf2ubkVJxNMy0KmDptQ97pNEVTtoRBvy9mOKgN4F3SeUYxOtN-shTwbFFMlvPJ2VSUFFPhCnoumYxOlrlNLgPyHXJ8KSK6S3opzHyNUAGQk-CTioSFgdSxCIT2Qx3GzPUT5pk-cRp58Lyq78HtJV8EflG1sBzlx2v59ckbFFrLi9W57Q9Zccrrzc5Byxk40BLtgbYDkxInGAeeSORAuZFRfbKBIudVqmurY_h2FDD4Y7AS--SJ5cAKHSmGAJ2KRVny8ccv_8H0-VOH6XnNlGQAHiXqtAt4J6z81eFc73CCnlEd8hoCtFmVkv_ZkfBkA9qLyY9bMg6KYX2pyRYVz5AFgwh47lUYb1fWx9qNIQNK3EF_Z-m7lHQ6sQXSBzadmkX3_z2vDXJt9-hgn--PD_cekOsemK94T-i566Q3LxbmIZibc_nI7nFKvl62UvkNOniZcQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLZGJyFeEOO2wmAGgYCHrGkuTvqA0MZarQzKNBjaW7AdZ63UJSFpQf0V_B9-Hec4TljQhHjZa33iOj6fzyU-F0KeucIWIhTM8n3JMSVnYPEEnBUVKrDOY1fGHB3FDxN2cOK9O_VP18ivOhcGwyprmagFdZxJ_Ebewy5KoFvB_-4lJiziaH_0Jv9mYQcpvGmt22lUEDlUqx_gvpWvx_vA6-eOMxp-fntgmQ4DlgS7e2GB9SGUG0qWBFxwgYJagYUNqIwDacdh7DtykCjwIBWzhRxwmwcSEM2S2ANK24V5r5H1ALRi2CHre8PJ0XGtB0CSMGaS9dyg3zPY2MmzVO3oC0zPbSlD3TOg0QydfJ6Vl5m9f0dvXlCHo1vkprFj6W4FvA2yptLbZMNIipK-NOWsX90hP4c5AAFxOKdV0x3EBZ1iHE4G8FXgB1Ddqpzy81kW8wKWTpsAeDpL0bAtYdLvyzlOqsN5V3SRUYzV1B8wOTxbFNPVYno-4yXFxLiCXkgto9NVrlPNYPguObkSJt0jnRRWvkkoBwAK8FB5wnxPxCH3eOz6sR8y202Yo7rEqvkR5VW1j0hf-QXgJVUbGyH_IsO_LtlDpjW0WKtb_5AVZ5E5-hHIPAXqLYkdkH1gYOICQ8_hiehLO1CyS7aR5VGV-NpInGg38Bj8MdiMXfJUU2C9jhSRf8aXZRmNP375D6JPxy2iF4YoyQA8kpskDHgnrAPWotxqUYLUka3hTQRovStl9Od8wpM1aC8fftIM46QY5JeqbFnRDJjXD4DmfoXxZmddrOToMxgJW-hvbX17JJ1Ndbn0vk6uZsGDf69rm1wHgRK9H08OH5IbDtiyeGno2FuksyiW6hHYngvx2BxySr5etVz5DfsRnww |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Epicardial+electrical+heterogeneity+after+amiodarone+treatment+increases+vulnerability+to+ventricular+arrhythmias+under+therapeutic+hypothermia&rft.jtitle=PloS+one&rft.au=Lin%2C+Chin-Yu&rft.au=Chang%2C+Ting-Yung&rft.au=Hu%2C+Yu-Feng&rft.au=Hsieh%2C+Yu-Cheng&rft.date=2023-04-20&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=18&rft.issue=4&rft.spage=e0282943&rft_id=info:doi/10.1371%2Fjournal.pone.0282943&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |