Repeated short climatic change affects the epidermal differentiation program and leads to matrix remodeling in a human organotypic skin model

• Published in: Clinical, cosmetic and investigational dermatology Vol. 10; pp. 43 - 50
• Main Authors: Barbollat-Boutrand, Laetitia, Thepot, Amelie, Muther, Charlotte, Boher, Aurelie, Robic, Julie, Guere, Christelle, Vie, Katell, Damour, Odile, Lamartine, Jerome
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2017; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Aging; Cell culture; Cell differentiation; Climate change; climatic changes; collagen; Environmental aspects; Fibroblasts; Gene expression; Genomes; Humidity; Medical climatology; Medical research; organotypic tissue; Original Research; Plastic surgery; Polyclonal antibodies; Protein expression; Proteins; Skin; Software; transcriptome; Variance analysis; France; United States > US; Germany; collagen; skin; organotypic tissue; transcriptome; climatic changes

Human skin is subject to frequent changes in ambient temperature and humidity and needs to cope with these environmental modifications. To decipher the molecular response of human skin to repeated climatic change, a versatile model of skin equivalent subject to "hot-wet" (40°C, 80% relativ...