Effects of Rhazya Stricta plant organic extracts on human induced pluripotent stem cells derived neural stem cells
Rhazya Stricta (R. stricta) has been employed as a natural remedy for several diseases for centuries. Numerous studies revealed that R. stricta extracts contain alkaloids, tannins, and flavonoids that possess antimicrobial, anticancer, antihypertensive, and antioxidant activities. In this study, we...
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Published in | PloS one Vol. 18; no. 7; p. e0288032 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Public Library of Science
21.07.2023
Public Library of Science (PLoS) |
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Abstract | Rhazya Stricta (R. stricta) has been employed as a natural remedy for several diseases for centuries. Numerous studies revealed that R. stricta extracts contain alkaloids, tannins, and flavonoids that possess antimicrobial, anticancer, antihypertensive, and antioxidant activities. In this study, we examined the effects of organic extracts from different parts of R. stricta plant on human pluripotent stem cells (hiPSCs)-derived neural stem cells (NSCs) for medical purposes. NSCs were incubated with different concentrations of organic extracts from the leaves, stem, and fruits, and we assessed the growth and viability of the cells by using MTS assay and the chemical composition of the potential plant extract by using gas chromatography-mass spectrometry (GC/MS). Our results revealed that the methanolic extract from the stem increased NSCs growth significantly, particularly at a concentration of 25 μg/ml. GC/MS analysis was utilized to identify the potential compounds of the methanolic extract. In conclusion, our results demonstrated for the first time that methanolic stem extract of R. stricta contains compounds that can positively impact NSCs growth. These compounds can be further investigated to determine the potential bioactive compounds that can be used for research and medical purposes. |
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AbstractList | Rhazya Stricta ( R . stricta) has been employed as a natural remedy for several diseases for centuries. Numerous studies revealed that R . stricta extracts contain alkaloids, tannins, and flavonoids that possess antimicrobial, anticancer, antihypertensive, and antioxidant activities. In this study, we examined the effects of organic extracts from different parts of R . stricta plant on human pluripotent stem cells (hiPSCs)-derived neural stem cells (NSCs) for medical purposes. NSCs were incubated with different concentrations of organic extracts from the leaves, stem, and fruits, and we assessed the growth and viability of the cells by using MTS assay and the chemical composition of the potential plant extract by using gas chromatography-mass spectrometry (GC/MS). Our results revealed that the methanolic extract from the stem increased NSCs growth significantly, particularly at a concentration of 25 μg/ml. GC/MS analysis was utilized to identify the potential compounds of the methanolic extract. In conclusion, our results demonstrated for the first time that methanolic stem extract of R . stricta contains compounds that can positively impact NSCs growth. These compounds can be further investigated to determine the potential bioactive compounds that can be used for research and medical purposes. Rhazya Stricta (R. stricta) has been employed as a natural remedy for several diseases for centuries. Numerous studies revealed that R. stricta extracts contain alkaloids, tannins, and flavonoids that possess antimicrobial, anticancer, antihypertensive, and antioxidant activities. In this study, we examined the effects of organic extracts from different parts of R. stricta plant on human pluripotent stem cells (hiPSCs)-derived neural stem cells (NSCs) for medical purposes. NSCs were incubated with different concentrations of organic extracts from the leaves, stem, and fruits, and we assessed the growth and viability of the cells by using MTS assay and the chemical composition of the potential plant extract by using gas chromatography-mass spectrometry (GC/MS). Our results revealed that the methanolic extract from the stem increased NSCs growth significantly, particularly at a concentration of 25 [mu]g/ml. GC/MS analysis was utilized to identify the potential compounds of the methanolic extract. In conclusion, our results demonstrated for the first time that methanolic stem extract of R. stricta contains compounds that can positively impact NSCs growth. These compounds can be further investigated to determine the potential bioactive compounds that can be used for research and medical purposes. Rhazya Stricta ( R . stricta) has been employed as a natural remedy for several diseases for centuries. Numerous studies revealed that R . stricta extracts contain alkaloids, tannins, and flavonoids that possess antimicrobial, anticancer, antihypertensive, and antioxidant activities. In this study, we examined the effects of organic extracts from different parts of R . stricta plant on human pluripotent stem cells (hiPSCs)-derived neural stem cells (NSCs) for medical purposes. NSCs were incubated with different concentrations of organic extracts from the leaves, stem, and fruits, and we assessed the growth and viability of the cells by using MTS assay and the chemical composition of the potential plant extract by using gas chromatography-mass spectrometry (GC/MS). Our results revealed that the methanolic extract from the stem increased NSCs growth significantly, particularly at a concentration of 25 μg/ml. GC/MS analysis was utilized to identify the potential compounds of the methanolic extract. In conclusion, our results demonstrated for the first time that methanolic stem extract of R . stricta contains compounds that can positively impact NSCs growth. These compounds can be further investigated to determine the potential bioactive compounds that can be used for research and medical purposes. |
Audience | Academic |
Author | Alghamdi, Fatimah Othman Alagrafi, Faisal Sultan Alamari, Hala Abdulrahman Aodah, Alhassan Hamood Alawad, Abdullah Othman Fallatah, Hussam Mokhtar Alfahad, Ahmed Jaman Fallatah, Mohannad Mokhtar Alyousef, Sultan Suleiman Alanazi, Ibrahim Oqla Bakhrebah, Muhammed Adnan |
AuthorAffiliation | 2 Bioengineering Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia Adama Science and Technology University, ETHIOPIA 3 Waste Management and Recycling Institute, Sustainability and Environment Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia 4 Advanced Diagnostics and Therapeutics Technologies Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia 1 Aging Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia |
AuthorAffiliation_xml | – name: 3 Waste Management and Recycling Institute, Sustainability and Environment Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia – name: 1 Aging Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia – name: 2 Bioengineering Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia – name: 4 Advanced Diagnostics and Therapeutics Technologies Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia – name: Adama Science and Technology University, ETHIOPIA |
Author_xml | – sequence: 1 givenname: Abdullah Othman orcidid: 0000-0003-1924-5879 surname: Alawad fullname: Alawad, Abdullah Othman organization: Aging Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia – sequence: 2 givenname: Faisal Sultan surname: Alagrafi fullname: Alagrafi, Faisal Sultan organization: Aging Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia – sequence: 3 givenname: Ahmed Jaman surname: Alfahad fullname: Alfahad, Ahmed Jaman organization: Bioengineering Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia – sequence: 4 givenname: Hala Abdulrahman surname: Alamari fullname: Alamari, Hala Abdulrahman organization: Bioengineering Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia – sequence: 5 givenname: Fatimah Othman surname: Alghamdi fullname: Alghamdi, Fatimah Othman organization: Bioengineering Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia – sequence: 6 givenname: Hussam Mokhtar surname: Fallatah fullname: Fallatah, Hussam Mokhtar organization: Waste Management and Recycling Institute, Sustainability and Environment Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia – sequence: 7 givenname: Alhassan Hamood surname: Aodah fullname: Aodah, Alhassan Hamood organization: Advanced Diagnostics and Therapeutics Technologies Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia – sequence: 8 givenname: Sultan Suleiman surname: Alyousef fullname: Alyousef, Sultan Suleiman organization: Advanced Diagnostics and Therapeutics Technologies Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia – sequence: 9 givenname: Muhammed Adnan surname: Bakhrebah fullname: Bakhrebah, Muhammed Adnan organization: Advanced Diagnostics and Therapeutics Technologies Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia – sequence: 10 givenname: Ibrahim Oqla orcidid: 0000-0002-8479-7875 surname: Alanazi fullname: Alanazi, Ibrahim Oqla organization: Aging Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia – sequence: 11 givenname: Mohannad Mokhtar orcidid: 0000-0002-4483-7131 surname: Fallatah fullname: Fallatah, Mohannad Mokhtar organization: Advanced Diagnostics and Therapeutics Technologies Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia |
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Snippet | Rhazya Stricta (R. stricta) has been employed as a natural remedy for several diseases for centuries. Numerous studies revealed that R. stricta extracts... Rhazya Stricta ( R . stricta) has been employed as a natural remedy for several diseases for centuries. Numerous studies revealed that R . stricta extracts... Rhazya Stricta ( R . stricta) has been employed as a natural remedy for several diseases for centuries. Numerous studies revealed that R . stricta extracts... |
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SubjectTerms | Alkaloids - analysis Alzheimer's disease Alzheimers disease Anticancer properties Antihypertensives Antioxidants - chemistry Apocynaceae - chemistry Bioactive compounds Biological activity Biological products Biology and Life Sciences Chemical composition Chromatography Ethylenediaminetetraacetic acid Flavonoids Gas chromatography Health aspects Herbal medicine Humans Induced Pluripotent Stem Cells Mass spectrometry Mass spectroscopy Medical research Natural products Neural stem cells Physical Sciences Plant extracts Plant Extracts - chemistry Plant Leaves - chemistry Pluripotency Properties Research and Analysis Methods Scientific equipment and supplies industry Scientific imaging Stem cell research Stem cells Tannic acid |
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Title | Effects of Rhazya Stricta plant organic extracts on human induced pluripotent stem cells derived neural stem cells |
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