Effects of Rhazya Stricta plant organic extracts on human induced pluripotent stem cells derived neural stem cells

Rhazya Stricta (R. stricta) has been employed as a natural remedy for several diseases for centuries. Numerous studies revealed that R. stricta extracts contain alkaloids, tannins, and flavonoids that possess antimicrobial, anticancer, antihypertensive, and antioxidant activities. In this study, we...

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Published inPloS one Vol. 18; no. 7; p. e0288032
Main Authors Alawad, Abdullah Othman, Alagrafi, Faisal Sultan, Alfahad, Ahmed Jaman, Alamari, Hala Abdulrahman, Alghamdi, Fatimah Othman, Fallatah, Hussam Mokhtar, Aodah, Alhassan Hamood, Alyousef, Sultan Suleiman, Bakhrebah, Muhammed Adnan, Alanazi, Ibrahim Oqla, Fallatah, Mohannad Mokhtar
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 21.07.2023
Public Library of Science (PLoS)
Subjects
Alkaloids - analysis
Alzheimer's disease
Alzheimers disease
Anticancer properties
Antihypertensives
Antioxidants - chemistry
Apocynaceae - chemistry
Bioactive compounds
Biological activity
Biological products
Biology and Life Sciences
Chemical composition
Chromatography
Ethylenediaminetetraacetic acid
Flavonoids
Gas chromatography
Health aspects
Herbal medicine
Humans
Induced Pluripotent Stem Cells
Mass spectrometry
Mass spectroscopy
Medical research
Natural products
Neural stem cells
Physical Sciences
Plant extracts
Plant Extracts - chemistry
Plant Leaves - chemistry
Pluripotency
Properties
Research and Analysis Methods
Scientific equipment and supplies industry
Scientific imaging
Stem cell research
Stem cells
Tannic acid
Saudi Arabia
United States
United States > US
Online AccessGet full text

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Abstract Rhazya Stricta (R. stricta) has been employed as a natural remedy for several diseases for centuries. Numerous studies revealed that R. stricta extracts contain alkaloids, tannins, and flavonoids that possess antimicrobial, anticancer, antihypertensive, and antioxidant activities. In this study, we examined the effects of organic extracts from different parts of R. stricta plant on human pluripotent stem cells (hiPSCs)-derived neural stem cells (NSCs) for medical purposes. NSCs were incubated with different concentrations of organic extracts from the leaves, stem, and fruits, and we assessed the growth and viability of the cells by using MTS assay and the chemical composition of the potential plant extract by using gas chromatography-mass spectrometry (GC/MS). Our results revealed that the methanolic extract from the stem increased NSCs growth significantly, particularly at a concentration of 25 μg/ml. GC/MS analysis was utilized to identify the potential compounds of the methanolic extract. In conclusion, our results demonstrated for the first time that methanolic stem extract of R. stricta contains compounds that can positively impact NSCs growth. These compounds can be further investigated to determine the potential bioactive compounds that can be used for research and medical purposes.
AbstractList Rhazya Stricta ( R . stricta) has been employed as a natural remedy for several diseases for centuries. Numerous studies revealed that R . stricta extracts contain alkaloids, tannins, and flavonoids that possess antimicrobial, anticancer, antihypertensive, and antioxidant activities. In this study, we examined the effects of organic extracts from different parts of R . stricta plant on human pluripotent stem cells (hiPSCs)-derived neural stem cells (NSCs) for medical purposes. NSCs were incubated with different concentrations of organic extracts from the leaves, stem, and fruits, and we assessed the growth and viability of the cells by using MTS assay and the chemical composition of the potential plant extract by using gas chromatography-mass spectrometry (GC/MS). Our results revealed that the methanolic extract from the stem increased NSCs growth significantly, particularly at a concentration of 25 μg/ml. GC/MS analysis was utilized to identify the potential compounds of the methanolic extract. In conclusion, our results demonstrated for the first time that methanolic stem extract of R . stricta contains compounds that can positively impact NSCs growth. These compounds can be further investigated to determine the potential bioactive compounds that can be used for research and medical purposes.
Rhazya Stricta (R. stricta) has been employed as a natural remedy for several diseases for centuries. Numerous studies revealed that R. stricta extracts contain alkaloids, tannins, and flavonoids that possess antimicrobial, anticancer, antihypertensive, and antioxidant activities. In this study, we examined the effects of organic extracts from different parts of R. stricta plant on human pluripotent stem cells (hiPSCs)-derived neural stem cells (NSCs) for medical purposes. NSCs were incubated with different concentrations of organic extracts from the leaves, stem, and fruits, and we assessed the growth and viability of the cells by using MTS assay and the chemical composition of the potential plant extract by using gas chromatography-mass spectrometry (GC/MS). Our results revealed that the methanolic extract from the stem increased NSCs growth significantly, particularly at a concentration of 25 [mu]g/ml. GC/MS analysis was utilized to identify the potential compounds of the methanolic extract. In conclusion, our results demonstrated for the first time that methanolic stem extract of R. stricta contains compounds that can positively impact NSCs growth. These compounds can be further investigated to determine the potential bioactive compounds that can be used for research and medical purposes.
Rhazya Stricta ( R . stricta) has been employed as a natural remedy for several diseases for centuries. Numerous studies revealed that R . stricta extracts contain alkaloids, tannins, and flavonoids that possess antimicrobial, anticancer, antihypertensive, and antioxidant activities. In this study, we examined the effects of organic extracts from different parts of R . stricta plant on human pluripotent stem cells (hiPSCs)-derived neural stem cells (NSCs) for medical purposes. NSCs were incubated with different concentrations of organic extracts from the leaves, stem, and fruits, and we assessed the growth and viability of the cells by using MTS assay and the chemical composition of the potential plant extract by using gas chromatography-mass spectrometry (GC/MS). Our results revealed that the methanolic extract from the stem increased NSCs growth significantly, particularly at a concentration of 25 μg/ml. GC/MS analysis was utilized to identify the potential compounds of the methanolic extract. In conclusion, our results demonstrated for the first time that methanolic stem extract of R . stricta contains compounds that can positively impact NSCs growth. These compounds can be further investigated to determine the potential bioactive compounds that can be used for research and medical purposes.
Audience Academic
Author Alghamdi, Fatimah Othman
Alagrafi, Faisal Sultan
Alamari, Hala Abdulrahman
Aodah, Alhassan Hamood
Alawad, Abdullah Othman
Fallatah, Hussam Mokhtar
Alfahad, Ahmed Jaman
Fallatah, Mohannad Mokhtar
Alyousef, Sultan Suleiman
Alanazi, Ibrahim Oqla
Bakhrebah, Muhammed Adnan
AuthorAffiliation 2 Bioengineering Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia
Adama Science and Technology University, ETHIOPIA
3 Waste Management and Recycling Institute, Sustainability and Environment Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia
4 Advanced Diagnostics and Therapeutics Technologies Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia
1 Aging Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia
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2023 Alawad et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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crossref_primary_10_1371_journal_pone_0288032
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PublicationCentury 2000
PublicationDate 2023-07-21
PublicationDateYYYYMMDD 2023-07-21
PublicationDate_xml – month: 07
  year: 2023
  text: 2023-07-21
  day: 21
PublicationDecade 2020
PublicationPlace United States
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PublicationTitle PloS one
PublicationTitleAlternate PLoS One
PublicationYear 2023
Publisher Public Library of Science
Public Library of Science (PLoS)
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SSID ssj0053866
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Snippet Rhazya Stricta (R. stricta) has been employed as a natural remedy for several diseases for centuries. Numerous studies revealed that R. stricta extracts...
Rhazya Stricta ( R . stricta) has been employed as a natural remedy for several diseases for centuries. Numerous studies revealed that R . stricta extracts...
Rhazya Stricta ( R . stricta) has been employed as a natural remedy for several diseases for centuries. Numerous studies revealed that R . stricta extracts...
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SubjectTerms Alkaloids - analysis
Alzheimer's disease
Alzheimers disease
Anticancer properties
Antihypertensives
Antioxidants - chemistry
Apocynaceae - chemistry
Bioactive compounds
Biological activity
Biological products
Biology and Life Sciences
Chemical composition
Chromatography
Ethylenediaminetetraacetic acid
Flavonoids
Gas chromatography
Health aspects
Herbal medicine
Humans
Induced Pluripotent Stem Cells
Mass spectrometry
Mass spectroscopy
Medical research
Natural products
Neural stem cells
Physical Sciences
Plant extracts
Plant Extracts - chemistry
Plant Leaves - chemistry
Pluripotency
Properties
Research and Analysis Methods
Scientific equipment and supplies industry
Scientific imaging
Stem cell research
Stem cells
Tannic acid
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Title Effects of Rhazya Stricta plant organic extracts on human induced pluripotent stem cells derived neural stem cells
URI https://www.ncbi.nlm.nih.gov/pubmed/37478090
https://www.proquest.com/docview/2840628422
https://search.proquest.com/docview/2841021609
https://pubmed.ncbi.nlm.nih.gov/PMC10361509
https://doaj.org/article/a62a02427e7d43ae8a4bc88d9387c36b
http://dx.doi.org/10.1371/journal.pone.0288032
Volume 18
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