Using in Vitro High Throughput Screening Assays to Identify Potential Endocrine-Disrupting Chemicals

• Published in: Environmental health perspectives Vol. 121; no. 1; pp. 7 - 14
• Main Authors: Rotroff, Daniel M., Dix, David J., Houck, Keith A., Knudsen, Thomas B., Martin, Matthew T., McLaurin, Keith W., Reif, David M., Crofton, Kevin M., Singh, Amar V., Xia, Menghang, Huang, Ruili, Judson, Richard S.
• Format: Journal Article
• Language: English
• Published: United States National Institute of Environmental Health Sciences 01.01.2013
• Subjects: Accuracy; Androgens; Androgens - analysis; Assaying; Balancing; Bioassays; Chemicals; Endocrine disruptors; Endocrine Disruptors - analysis; Environment protection; Environmental protection; Enzymes; Estrogens; Estrogens - analysis; High-throughput screening (Biochemical assaying); High-Throughput Screening Assays - methods; Homeostasis; Hormones; Identification and classification; In vitro testing; Mathematical models; Metabolism; Receptors; Review; Screening; Studies; Thyroid; Thyroid gland; Toxicity; United States; United States Environmental Protection Agency; United States; United States > US

Over the past 20 years, an increased focus on detecting environmental chemicals that pose a risk of adverse effects due to endocrine disruption has driven the creation of the U.S. Environmental Protection Agency (EPA) Endocrine Disruptor Screening Program (EDSP). Thousands of chemicals are subject t...