Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer’s disease

• Published in: Acta neuropathologica Vol. 120; no. 2; pp. 185 - 193
• Main Authors: Portelius, Erik, Bogdanovic, Nenad, Gustavsson, Mikael K., Volkmann, Inga, Brinkmalm, Gunnar, Zetterberg, Henrik, Winblad, Bengt, Blennow, Kaj
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.08.2010; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - classification; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Amyloid precursor protein; Brain; Brain - metabolism; Brain - pathology; Disease; Female; Genes; Humans; Immunoprecipitation; Immunoprecipitation - methods; Male; Mass spectrometry; Mass Spectrometry - methods; Medicine; Medicine & Public Health; Middle Aged; Mutation; Neuropathology; Neurosciences; Neurotoxicity; Original Paper; Pathogenesis; Pathology; Patients; Peptide Fragments - metabolism; Protein Isoforms - metabolism; Proteins; Psychiatry; Psykiatri; Scientific imaging; Statistics as Topic; Sweden; Brain; Immunoprecipitation; Alzheimer’s disease; Mass spectrometry; Amyloid precursor protein

A proposed key event in the pathogenesis of Alzheimer’s disease (AD) is the formation of neurotoxic amyloid β (Aβ) oligomers and amyloid plaques in specific brain regions that are affected by the disease. The main plaque component is the 42 amino acid isoform of Αβ (Aβ1-42), which is thought to init...