Crosstalk between cancer and immune cells: Role of tumor‐associated macrophages in the tumor microenvironment

• Published in: Cancer medicine (Malden, MA) Vol. 8; no. 10; pp. 4709 - 4721
• Main Authors: Wang, Jing, Li, Danyang, Cang, Huaixing, Guo, Bo
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.08.2019; John Wiley and Sons Inc; Wiley
• Subjects: Angiogenesis; Breast cancer; Cancer Biology; Cell adhesion & migration; Cell cycle; Chemokines; chronic inflammation; Cytokines; Cytokines - metabolism; Developmental stages; Disease Progression; Gene expression; Gene Regulatory Networks; Genotype & phenotype; Growth factors; Humans; immune suppression; Infections; Inflammation; Intercellular Signaling Peptides and Proteins - metabolism; Lymphocytes; Macrophages; Macrophages - immunology; Metastasis; Motility; Neoplasms - immunology; Review; Roles; Signal Transduction; TAMs; tumor; Tumor Microenvironment; Tumor necrosis factor-TNF; Tumorigenesis; Vascular endothelial growth factor; TAMs; immune suppression; angiogenesis; tumor; chronic inflammation

Tumor microenvironment is a complex system that contains multiple cells and cytokines. Among the multiple immune cells, macrophage is particularly abundant and plays an important role throughout the tumor progression process, namely, tumor‐associated macrophage (TAM) in this special tumor microenvir...