Reduction of Quinones by NADH Catalyzed by Organoiridium Complexes

• Published in: Angewandte Chemie International Edition Vol. 52; no. 15; pp. 4194 - 4197
• Main Authors: Liu, Zhe, Deeth, Robert J., Butler, Jennifer S., Habtemariam, Abraha, Newton, Mark E., Sadler, Peter J.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 08.04.2013; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Catalysis; Communications; hydride transfer; Hydrides; iridium; Iridium - chemistry; Ligands; Mathematical analysis; Metalorganic compounds; Molecular Structure; NAD - chemistry; NADH; Organometallic Compounds - chemistry; Oxidation-Reduction; Quinones; Quinones - chemistry; radical reactions; Reduction; Valence

One electron at a time: Half‐sandwich organometallic cyclopentadienyl–IrIII complexes containing N,N‐chelated ligands can catalyze the reduction of quinones (Q), such as vitamin K3, to semiquinones (Q.−) by coenzyme NADH (see picture). DFT calculations suggest that the mechanism involves hydride tra...