Growth hormone (GH) replacement decreases serum total and LDL-cholesterol in hypopituitary patients on maintenance HMG CoA reductase inhibitor (statin) therapy

• Published in: Clinical endocrinology (Oxford) Vol. 67; no. 4; pp. 623 - 628
• Main Authors: Monson, John P., Jönsson, Peter, Koltowska-Häggström, Maria, Kourides, Ione
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2007; Blackwell
• Subjects: Adenohypophyseal hormone; Antilipemic agent; Biological and medical sciences; Biological fluid; Case-Control Studies; Cholesterol; Cholesterol - blood; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Databases, Factual; Disorders of blood lipids. Hyperlipoproteinemia; Drug Administration Schedule; Drug Industry; Drug Therapy, Combination; Dyslipemia; Endocrinology; Endocrinopathies; Endocrinopathy; FARMACI; Female; Fundamental and applied biological sciences. Psychology; HMG-CoA reductase inhibitor; Hormone therapy; Human; Human Growth Hormone - therapeutic use; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Hypercholesterolemia; Hyperlipoproteinemia; Hypophyseal insufficiency; Hypopituitarism - blood; Hypopituitarism - drug therapy; Hypothalamus. Hypophysis. Epiphysis (diseases); Insulin-Like Growth Factor I - analysis; Lipids; Lipoprotein LDL; Maintenance; Male; Medical sciences; Metabolic diseases; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Original; Patient; PHARMACY; Pituitary diseases; Replacement therapy; Serum; Somatotropin hormone; Statin derivative; Statistics, Nonparametric; Therapy; Triglycerides - blood; Vertebrates: endocrinology; Endocrinopathy; Human; Biological fluid; Therapy; Replacement therapy; Hormone therapy; Somatotropin hormone; Lipids; Metabolic diseases; Patient; Hyperlipoproteinemia; Statin derivative; Maintenance; Cholesterol; Lipoprotein LDL; Hypercholesterolemia; Adenohypophyseal hormone; Hypophyseal insufficiency; HMG-CoA reductase inhibitor; Pituitary diseases; Serum; Dyslipemia; Endocrinology; Antilipemic agent

Summary Objective  Adult onset GH deficiency (GHD) is characterized by abnormalities of serum lipoprotein profiles and GH replacement results in favourable alterations in serum total and low density lipoprotein (LDL)‐cholesterol. Preliminary evidence has indicated that the effect of GH replacement i...