Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis

• Published in: Circulation research Vol. 127; no. 7; pp. 877 - 892
• Main Authors: Flynn, Michelle C., Kraakman, Michael J., Tikellis, Christos, Lee, Man K.S., Hanssen, Nordin M.J., Kammoun, Helene L., Pickering, Raelene J., Dragoljevic, Dragana, Al-Sharea, Annas, Barrett, Tessa J., Hortle, Fiona, Byrne, Frances L., Olzomer, Ellen, McCarthy, Domenica A., Schalkwijk, Casper G., Forbes, Josephine M., Hoehn, Kyle, Makowski, Liza, Lancaster, Graeme I., El-Osta, Assam, Fisher, Edward A., Goldberg, Ira J., Cooper, Mark E., Nagareddy, Prabhakara R., Thomas, Merlin C., Murphy, Andrew J.
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 11.09.2020
• Subjects: atherosclerosis; stem cells; diabetes mellitus; metabolism; inflammation

RATIONALE:Treatment efficacy for diabetes mellitus is largely determined by assessment of HbA1c (glycated hemoglobin A1c) levels, which poorly reflects direct glucose variation. People with prediabetes and diabetes mellitus spend >50% of their time outside the optimal glucose range. These glucose...