An Efficient Method for the In Vitro Production of Azol(in)e-Based Cyclic Peptides

• Published in: Angewandte Chemie International Edition Vol. 53; no. 51; pp. 14171 - 14174
• Main Authors: Houssen, Wael E., Bent, Andrew F., McEwan, Andrew R., Pieiller, Nathalie, Tabudravu, Jioji, Koehnke, Jesko, Mann, Greg, Adaba, Rosemary I., Thomas, Louise, Hawas, Usama W., Liu, Huanting, Schwarz-Linek, Ulrich, Smith, Margaret C. M., Naismith, James H., Jaspars, Marcel
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 15.12.2014; WILEY‐VCH Verlag; Wiley; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Amino acids; Azoles - chemistry; Azoles - metabolism; Biomedical materials; biosynthesis; Chemistry; Chemistry, Multidisciplinary; Communications; cyanobactins; cyclic peptides; Enzymes; Heterocyclic compounds; Molecular Conformation; Oxidase; Oxidoreductases - chemistry; Oxidoreductases - metabolism; patellamides; Peptide Hydrolases - chemistry; Peptide Hydrolases - metabolism; Peptides; Peptides, Cyclic - biosynthesis; Peptides, Cyclic - chemistry; Pharmaceuticals; Phosphorus-Oxygen Lyases - chemistry; Phosphorus-Oxygen Lyases - metabolism; Physical Sciences; ribosomal peptides; Scaffolds; Science & Technology; Synthesis; cyclic peptides; ROUTE; ribosomal peptides; biosynthesis; cyanobactins; patellamides; DISCOVERY; MACROCYCLIZATION

Heterocycle‐containing cyclic peptides are promising scaffolds for the pharmaceutical industry but their chemical synthesis is very challenging. A new universal method has been devised to prepare these compounds by using a set of engineered marine‐derived enzymes and substrates obtained from a famil...