基于网络药理学预测三草颗粒治疗自身免疫性肝炎的作用机制
目的：基于网络药理学,初步探讨三草颗粒治疗自身免疫性肝炎的作用机制。方法：通过建立三草颗粒药物靶点数据集、自身免疫性肝炎疾病靶点数据集,构建三草颗粒治疗自身免疫性肝炎的＂成分-靶点-疾病＂交互网络,并通过可视化分析、网络中各节点的拓扑参数分析,预测三草颗粒治疗自身免疫性肝炎的作用机制。结果：网络药理学分析结果显示,三草颗粒通过直接作用于雄激素受体、酪氨酸蛋白激酶、半胱氨酸蛋白酶-3、白细胞介素2、中性粒细胞弹性蛋白酶、组织蛋白酶K、雌激素受体、转化生长因子β-2、WAS蛋白、信号转导及转录激活因子等蛋白靶点,并通过调节自然杀伤细胞介导的细胞毒作用和T细胞受体信号通路和核转录因子kappa B信...
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| Published in | 中国医院用药评价与分析 Vol. 17; no. 10; pp. 1301 - 1303 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
成都中医药大学药学院,四川成都 611137
2017
解放军第302医院药学部,北京 100039%解放军第302医院药学部,北京,100039 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-2124 |
| DOI | 10.14009/j.issn.1672-2124.2017.10.002 |
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| Abstract | 目的：基于网络药理学,初步探讨三草颗粒治疗自身免疫性肝炎的作用机制。方法：通过建立三草颗粒药物靶点数据集、自身免疫性肝炎疾病靶点数据集,构建三草颗粒治疗自身免疫性肝炎的＂成分-靶点-疾病＂交互网络,并通过可视化分析、网络中各节点的拓扑参数分析,预测三草颗粒治疗自身免疫性肝炎的作用机制。结果：网络药理学分析结果显示,三草颗粒通过直接作用于雄激素受体、酪氨酸蛋白激酶、半胱氨酸蛋白酶-3、白细胞介素2、中性粒细胞弹性蛋白酶、组织蛋白酶K、雌激素受体、转化生长因子β-2、WAS蛋白、信号转导及转录激活因子等蛋白靶点,并通过调节自然杀伤细胞介导的细胞毒作用和T细胞受体信号通路和核转录因子kappa B信号通路等多通路,从而发挥治疗自身免疫性肝炎的作用。结论：三草颗粒主要通过干预机体炎症反应、调节机体免疫等治疗自身免疫性肝炎。 |
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| AbstractList | 目的：基于网络药理学,初步探讨三草颗粒治疗自身免疫性肝炎的作用机制。方法：通过建立三草颗粒药物靶点数据集、自身免疫性肝炎疾病靶点数据集,构建三草颗粒治疗自身免疫性肝炎的＂成分-靶点-疾病＂交互网络,并通过可视化分析、网络中各节点的拓扑参数分析,预测三草颗粒治疗自身免疫性肝炎的作用机制。结果：网络药理学分析结果显示,三草颗粒通过直接作用于雄激素受体、酪氨酸蛋白激酶、半胱氨酸蛋白酶-3、白细胞介素2、中性粒细胞弹性蛋白酶、组织蛋白酶K、雌激素受体、转化生长因子β-2、WAS蛋白、信号转导及转录激活因子等蛋白靶点,并通过调节自然杀伤细胞介导的细胞毒作用和T细胞受体信号通路和核转录因子kappa B信号通路等多通路,从而发挥治疗自身免疫性肝炎的作用。结论：三草颗粒主要通过干预机体炎症反应、调节机体免疫等治疗自身免疫性肝炎。 R932; 目的:基于网络药理学,初步探讨三草颗粒治疗自身免疫性肝炎的作用机制.方法:通过建立三草颗粒药物靶点数据集、自身免疫性肝炎疾病靶点数据集,构建三草颗粒治疗自身免疫性肝炎的"成分-靶点-疾病"交互网络,并通过可视化分析、网络中各节点的拓扑参数分析,预测三草颗粒治疗自身免疫性肝炎的作用机制.结果:网络药理学分析结果显示,三草颗粒通过直接作用于雄激素受体、酪氨酸蛋白激酶、半胱氨酸蛋白酶-3、白细胞介素2、中性粒细胞弹性蛋白酶、组织蛋白酶K、雌激素受体、转化生长因子β-2、WAS蛋白、信号转导及转录激活因子等蛋白靶点,并通过调节自然杀伤细胞介导的细胞毒作用和T细胞受体信号通路和核转录因子kappa B信号通路等多通路,从而发挥治疗自身免疫性肝炎的作用.结论:三草颗粒主要通过干预机体炎症反应、调节机体免疫等治疗自身免疫性肝炎. |
| Abstract_FL | OBJECTIVE:To preliminarily probe into Sancao granules in treatment of autoimmune hepatitis based on network pharmacology .METHODS:Through establishment of target data of Sancao granules and autoimmune hepatitis, development of "ingredients-target-disease" interactive network of Sancao granules in treatment of autoimmune hepatitis , the mechanism of Sancao granules in treatment of autoimmune hepatitis was predicted by visualized analysis and topological parameter analysis .RESULTS:According to network pharmacology , through directly affecting androgen receptor , tyrosine-protein kinase , caspase-3, interleukin 2, neutrophil elastase , cathepsin K, estrogen receptor, transforming growth factor β-2, wiskott-Aldrich syndrome (WAS) protein, signal transducer and activator of transcription and simultaneously regulating NF-kappa B signaling pathway , T cell receptor signaling pathway , Natural killer cell mediated cytotoxicity , Sancao granules could fully play its role in treatment of autoimmune hepatitis.CONCLUSIONS:Sancao granules can be used for the treatment of autoimmune hepatitis by intervening inflammatory response and mediating inflammation . |
| Author | 杨玉雪;张璐;王莹莹;周厚琴;陆小华;魏士长;赵艳玲 |
| AuthorAffiliation | 成都中医药大学药学院,四川成都611137;解放军第302医院药学部,北京100039 |
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| Author_FL | WANG Yingying LU Xiaohua ZHAO Yanling YANG Yuxue ZHANG Lu ZHOU Houqin WEI Shizhang |
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| Keywords | 网络药理学 三草颗粒 作用机制预测 Autoimmune hepatitis Mechanism prediction Sancao granules Network pharmacology 自身免疫性肝炎 |
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| Notes | Network pharmacology;Sancao granules;Autoimmune hepatitis;Mechanism prediction YANG Yuxue1,2, ZHANG Lu1,2, WANG Yingying1,2, ZHOU Houqin1,2, LU Xiaohua1,2, WEI Shizhang2, ZHAO Yanling2 （1. College of Pharmacy, Chengdu University of Traditional Chinese Medicine,Sichuan Chengdu 611137, China; 2. Dept. of Pharmacy, 302 Military Hospital of China, Beijing 100039, China） OBJECTIVE：To preliminarily probe into Sancao granules in treatment of autoimmune hepatitis based on network pharmacology .METHODS：Through establishment of target data of Sancao granules and autoimmune hepatitis, development of ＆quot;ingredients-target-disease＆quot; interactive network of Sancao granules in treatment of autoimmune hepatitis , the mechanism of Sancao granules in treatment of autoimmune hepatitis was predicted by visualized analysis and topological parameter analysis .RESULTS：According to network pharmacology , through directly affecting androgen receptor , tyrosine-protein kinase , caspase-3, interleukin 2, neutrophil elastase , cathe |
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| Title | 基于网络药理学预测三草颗粒治疗自身免疫性肝炎的作用机制 |
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