1202-P: Hepatic NgBR Is a Potential Resilience Factor for Preventing Obesity-Caused Insulin Resistance

• Published in: Diabetes (New York, N.Y.) Vol. 70; no. Supplement_1
• Main Authors: HU, WENQUAN, WANG, XIANG, MIAO, QING
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.06.2021
• Subjects: Adiponectin; AMP-activated protein kinase; Blood glucose; Cell surface; Diabetes; Diabetes mellitus; Gluconeogenesis; Hepatocytes; High fat diet; Insulin; Insulin resistance; Kinases; Liver; LKB1 protein; Localization; Nogo protein; Obesity; Phosphates; Transcription

Adiponectin is an adipocyte-secreted protein hormone and prevents the development of insulin resistance. The adiponectin-mediated activation of AMP-activated protein kinase (AMPK) pathway is essential for decreasing the expression of hepatic gluconeogenic enzymes and enhancing the hepatic effects of...