Intrahost evolution of the HIV-2 capsid correlates with progression to AIDS

• Published in: Virus evolution Vol. 8; no. 2; p. veac075
• Main Authors: Boswell, M T, Nazziwa, J, Kuroki, K, Palm, A, Karlson, S, Månsson, F, Biague, A, da Silva, Z J, Onyango, C O, de Silva, T I, Jaye, A, Norrgren, H, Medstrand, P, Jansson, M, Maenaka, K, Rowland-Jones, S L, Esbjörnsson, J
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 01.12.2022
• Subjects: Acquired immune deficiency syndrome; AIDS; Amino acids; capsid; Clinical Medicine; evolution; HIV; HIV-2; Human immunodeficiency virus; Infectious Medicine; Infektionsmedicin; Klinisk medicin; Medical and Health Sciences; Medicin och hälsovetenskap; p26; HIV-2; evolution; p26; capsid

Abstract HIV-2 infection will progress to AIDS in most patients without treatment, albeit at approximately half the rate of HIV-1 infection. HIV-2 capsid (p26) amino acid polymorphisms are associated with lower viral loads and enhanced processing of T cell epitopes, which may lead to protective Gag-...