Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells

• Published in: Nature (London) Vol. 546; no. 7660; pp. 667 - 670
• Main Authors: Zhu, Shu, Ding, Siyuan, Wang, Penghua, Wei, Zheng, Pan, Wen, Palm, Noah W., Yang, Yi, Yu, Hua, Li, Hua-Bing, Wang, Geng, Lei, Xuqiu, de Zoete, Marcel R., Zhao, Jun, Zheng, Yunjiang, Chen, Haiwei, Zhao, Yujiao, Jurado, Kellie A., Feng, Ningguo, Shan, Liang, Kluger, Yuval, Lu, Jun, Abraham, Clara, Fikrig, Erol, Greenberg, Harry B., Flavell, Richard A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.06.2017; Nature Publishing Group
• Subjects: 13/21; 13/95; 38/39; 38/89; 38/90; 38/91; 631/250/255/2514; 631/250/262/2106/2517; 64/60; 96/106; Adaptor proteins; Animals; Apoptosis Regulatory Proteins - metabolism; CARD Signaling Adaptor Proteins - metabolism; Caspase; Caspase 1 - metabolism; Caspase-1; Children; Cytokines; DEAD-box RNA Helicases - metabolism; Diarrhea; DNA helicase; Double-stranded RNA; Epithelial cells; Epithelial Cells - immunology; Epithelial Cells - metabolism; Epithelial Cells - virology; Fatalities; Feces; Female; Gastroenteritis; Health aspects; Humanities and Social Sciences; Immunity, Innate; In vivo methods and tests; Inflammasomes; Inflammasomes - chemistry; Inflammasomes - genetics; Inflammasomes - metabolism; Interferon; Interleukin-18 - immunology; Interleukins; Intestinal Mucosa - metabolism; Intestines - cytology; Intestines - immunology; Intracellular Signaling Peptides and Proteins; letter; Male; Maturation; Medical research; Mice; Mice, Inbred C57BL; Modulation; Mucosa; multidisciplinary; Pathogens; Phosphate-Binding Proteins; Proteins; Pyroptosis; Receptors, G-Protein-Coupled - deficiency; Receptors, G-Protein-Coupled - immunology; Receptors, G-Protein-Coupled - metabolism; Replication; Ribonucleic acid; Ribosomal DNA; RNA; RNA helicase; RNA, Double-Stranded - metabolism; Rodents; Rotavirus; Rotavirus - growth & development; Rotavirus - immunology; Rotavirus Infections - immunology; Rotavirus Infections - virology; Rotaviruses; Science; Signal transduction; Signaling; Small intestine; Viral infections; Viruses

The inflammasome receptor Nlrp9b defends against enteric viruses by interacting with double-stranded viral RNA-bound helicase Dhx9, triggering gasdermin-D-dependent pyroptotic cell death of infected cells and secretion of Il-18. Inflammasome defends against gastric bug Rotaviruses cause severe and o...