The transcription factor NKX2-3 mediates p21 expression and ectodysplasin-A signaling in the enamel knot for cusp formation in tooth development

• Published in: The Journal of biological chemistry Vol. 293; no. 38; pp. 14572 - 14584
• Main Authors: Han, Xue, Yoshizaki, Keigo, Miyazaki, Kanako, Arai, Chieko, Funada, Keita, Yuta, Tomomi, Tian, Tian, Chiba, Yuta, Saito, Kan, Iwamoto, Tsutomu, Yamada, Aya, Takahashi, Ichiro, Fukumoto, Satoshi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.09.2018; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; cell differentiation; cell proliferation; Cell Proliferation - physiology; Cyclin-Dependent Kinase Inhibitor p21 - genetics; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Dental Enamel - cytology; Dental Enamel - metabolism; dental growth; development; Developmental Biology; Ectodysplasins - metabolism; Edar Receptor; Epithelial Cells - metabolism; Female; Genes, Homeobox; Homeodomain Proteins - genetics; Homeodomain Proteins - physiology; Mice; Mice, Knockout; Morphogenesis; Nkx2–3; odontogenesis; Odontogenesis - genetics; Odontogenesis - physiology; Organ Culture Techniques; Pregnancy; Promoter Regions, Genetic; Signal Transduction - physiology; SOXB1 Transcription Factors - metabolism; tissue-specific transcription factor; tooth; Transcription Factors - genetics; Transcription Factors - physiology; transcription regulation; Transcription, Genetic; transcription regulation; development; cell differentiation; odontogenesis; cell proliferation; dental growth; tissue-specific transcription factor; tooth; Nkx2–3

Tooth morphogenesis is initiated by reciprocal interactions between the ectoderm and neural crest–derived mesenchyme. During tooth development, tooth cusps are regulated by precise control of proliferation of cell clusters, termed enamel knots, that are present among dental epithelial cells. The int...