Rumination and the default mode network: Meta-analysis of brain imaging studies and implications for depression

Rumination is strongly and consistently correlated with depression. Although multiple studies have explored the neural correlates of rumination, findings have been inconsistent and the mechanisms underlying rumination remain elusive. Functional brain imaging studies have identified areas in the defa...

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Published inNeuroImage (Orlando, Fla.) Vol. 206; p. 116287
Main Authors Zhou, Hui-Xia, Chen, Xiao, Shen, Yang-Qian, Li, Le, Chen, Ning-Xuan, Zhu, Zhi-Chen, Castellanos, Francisco Xavier, Yan, Chao-Gan
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.2020
Elsevier Limited
Elsevier
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Abstract Rumination is strongly and consistently correlated with depression. Although multiple studies have explored the neural correlates of rumination, findings have been inconsistent and the mechanisms underlying rumination remain elusive. Functional brain imaging studies have identified areas in the default mode network (DMN) that appear to be critically involved in ruminative processes. However, a meta-analysis to synthesize the findings of brain regions underlying rumination is currently lacking. Here, we conducted a meta-analysis consisting of experimental tasks that investigate rumination by using Signed Differential Mapping of 14 fMRI studies comprising 286 healthy participants. Furthermore, rather than treat the DMN as a unitary network, we examined the contribution of three DMN subsystems to rumination. Results confirm the suspected association between rumination and DMN activation, specifically implicating the DMN core regions and the dorsal medial prefrontal cortex subsystem. Based on these findings, we suggest a hypothesis of how DMN regions support rumination and present the implications of this model for treating major depressive disorder characterized by rumination. •Rumination is strongly and consistently correlated with depression.•Meta-analyze the findings of brain regions regarding to rumination.•Specifically examined the contribution of three DMN subsystems to rumination.•Rumination is specifically correlated with the DMN core regions and the dorsal medial prefrontal cortex subsystem.
AbstractList Rumination is strongly and consistently correlated with depression. Although multiple studies have explored the neural correlates of rumination, findings have been inconsistent and the mechanisms underlying rumination remain elusive. Functional brain imaging studies have identified areas in the default mode network (DMN) that appear to be critically involved in ruminative processes. However, a meta-analysis to synthesize the findings of brain regions underlying rumination is currently lacking. Here, we conducted a meta-analysis consisting of experimental tasks that investigate rumination by using Signed Differential Mapping of 14 fMRI studies comprising 286 healthy participants. Furthermore, rather than treat the DMN as a unitary network, we examined the contribution of three DMN subsystems to rumination. Results confirm the suspected association between rumination and DMN activation, specifically implicating the DMN core regions and the dorsal medial prefrontal cortex subsystem. Based on these findings, we suggest a hypothesis of how DMN regions support rumination and present the implications of this model for treating major depressive disorder characterized by rumination. •Rumination is strongly and consistently correlated with depression.•Meta-analyze the findings of brain regions regarding to rumination.•Specifically examined the contribution of three DMN subsystems to rumination.•Rumination is specifically correlated with the DMN core regions and the dorsal medial prefrontal cortex subsystem.
Rumination is strongly and consistently correlated with depression. Although multiple studies have explored the neural correlates of rumination, findings have been inconsistent and the mechanisms underlying rumination remain elusive. Functional brain imaging studies have identified areas in the default mode network (DMN) that appear to be critically involved in ruminative processes. However, a meta-analysis to synthesize the findings of brain regions underlying rumination is currently lacking. Here, we conducted a meta-analysis consisting of experimental tasks that investigate rumination by using Signed Differential Mapping of 14 fMRI studies comprising 286 healthy participants. Furthermore, rather than treat the DMN as a unitary network, we examined the contribution of three DMN subsystems to rumination. Results confirm the suspected association between rumination and DMN activation, specifically implicating the DMN core regions and the dorsal medial prefrontal cortex subsystem. Based on these findings, we suggest a hypothesis of how DMN regions support rumination and present the implications of this model for treating major depressive disorder characterized by rumination.
Rumination is strongly and consistently correlated with depression. Although multiple studies have explored the neural correlates of rumination, findings have been inconsistent and the mechanisms underlying rumination remain elusive. Functional brain imaging studies have identified areas in the default mode network (DMN) that appear to be critically involved in ruminative processes. However, a meta-analysis to synthesize the findings of brain regions underlying rumination is currently lacking. Here, we conducted a meta-analysis consisting of experimental tasks that investigate rumination by using Signed Differential Mapping of 14 fMRI studies comprising 286 healthy participants. Furthermore, rather than treat the DMN as a unitary network, we examined the contribution of three DMN subsystems to rumination. Results confirm the suspected association between rumination and DMN activation, specifically implicating the DMN core regions and the dorsal medial prefrontal cortex subsystem. Based on these findings, we suggest a hypothesis of how DMN regions support rumination and present the implications of this model for treating major depressive disorder characterized by rumination.Rumination is strongly and consistently correlated with depression. Although multiple studies have explored the neural correlates of rumination, findings have been inconsistent and the mechanisms underlying rumination remain elusive. Functional brain imaging studies have identified areas in the default mode network (DMN) that appear to be critically involved in ruminative processes. However, a meta-analysis to synthesize the findings of brain regions underlying rumination is currently lacking. Here, we conducted a meta-analysis consisting of experimental tasks that investigate rumination by using Signed Differential Mapping of 14 fMRI studies comprising 286 healthy participants. Furthermore, rather than treat the DMN as a unitary network, we examined the contribution of three DMN subsystems to rumination. Results confirm the suspected association between rumination and DMN activation, specifically implicating the DMN core regions and the dorsal medial prefrontal cortex subsystem. Based on these findings, we suggest a hypothesis of how DMN regions support rumination and present the implications of this model for treating major depressive disorder characterized by rumination.
ArticleNumber 116287
Author Shen, Yang-Qian
Chen, Ning-Xuan
Zhou, Hui-Xia
Li, Le
Castellanos, Francisco Xavier
Yan, Chao-Gan
Chen, Xiao
Zhu, Zhi-Chen
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  organization: CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China
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  fullname: Chen, Xiao
  organization: CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China
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  surname: Shen
  fullname: Shen, Yang-Qian
  organization: CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China
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  surname: Li
  fullname: Li, Le
  organization: CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China
– sequence: 5
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  surname: Chen
  fullname: Chen, Ning-Xuan
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  surname: Castellanos
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– sequence: 8
  givenname: Chao-Gan
  surname: Yan
  fullname: Yan, Chao-Gan
  email: yancg@psych.ac.cn
  organization: CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31655111$$D View this record in MEDLINE/PubMed
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Keywords Core regions
Default mode network
Depression
Rumination
Dorsal medial prefrontal cortex subsystem
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Snippet Rumination is strongly and consistently correlated with depression. Although multiple studies have explored the neural correlates of rumination, findings have...
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pubmed
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elsevier
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StartPage 116287
SubjectTerms Brain Mapping
Concrete
Core regions
Default mode network
Depression
Depression - diagnostic imaging
Depression - physiopathology
Dorsal medial prefrontal cortex subsystem
Functional magnetic resonance imaging
Humans
Medical imaging
Memory
Mental depression
Meta-analysis
Nerve Net - diagnostic imaging
Nerve Net - physiology
Neuroimaging
Prefrontal cortex
Prefrontal Cortex - diagnostic imaging
Prefrontal Cortex - physiology
Rumination
Rumination, Cognitive - physiology
Systematic review
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Title Rumination and the default mode network: Meta-analysis of brain imaging studies and implications for depression
URI https://www.clinicalkey.com/#!/content/1-s2.0-S105381191930878X
https://dx.doi.org/10.1016/j.neuroimage.2019.116287
https://www.ncbi.nlm.nih.gov/pubmed/31655111
https://www.proquest.com/docview/2340231870
https://www.proquest.com/docview/2309476176
https://doaj.org/article/673a0ce4f6764a4581760fb683a4e7f5
Volume 206
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