Rumination and the default mode network: Meta-analysis of brain imaging studies and implications for depression
Rumination is strongly and consistently correlated with depression. Although multiple studies have explored the neural correlates of rumination, findings have been inconsistent and the mechanisms underlying rumination remain elusive. Functional brain imaging studies have identified areas in the defa...
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Published in | NeuroImage (Orlando, Fla.) Vol. 206; p. 116287 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.02.2020
Elsevier Limited Elsevier |
Subjects | |
Online Access | Get full text |
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Abstract | Rumination is strongly and consistently correlated with depression. Although multiple studies have explored the neural correlates of rumination, findings have been inconsistent and the mechanisms underlying rumination remain elusive. Functional brain imaging studies have identified areas in the default mode network (DMN) that appear to be critically involved in ruminative processes. However, a meta-analysis to synthesize the findings of brain regions underlying rumination is currently lacking. Here, we conducted a meta-analysis consisting of experimental tasks that investigate rumination by using Signed Differential Mapping of 14 fMRI studies comprising 286 healthy participants. Furthermore, rather than treat the DMN as a unitary network, we examined the contribution of three DMN subsystems to rumination. Results confirm the suspected association between rumination and DMN activation, specifically implicating the DMN core regions and the dorsal medial prefrontal cortex subsystem. Based on these findings, we suggest a hypothesis of how DMN regions support rumination and present the implications of this model for treating major depressive disorder characterized by rumination.
•Rumination is strongly and consistently correlated with depression.•Meta-analyze the findings of brain regions regarding to rumination.•Specifically examined the contribution of three DMN subsystems to rumination.•Rumination is specifically correlated with the DMN core regions and the dorsal medial prefrontal cortex subsystem. |
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AbstractList | Rumination is strongly and consistently correlated with depression. Although multiple studies have explored the neural correlates of rumination, findings have been inconsistent and the mechanisms underlying rumination remain elusive. Functional brain imaging studies have identified areas in the default mode network (DMN) that appear to be critically involved in ruminative processes. However, a meta-analysis to synthesize the findings of brain regions underlying rumination is currently lacking. Here, we conducted a meta-analysis consisting of experimental tasks that investigate rumination by using Signed Differential Mapping of 14 fMRI studies comprising 286 healthy participants. Furthermore, rather than treat the DMN as a unitary network, we examined the contribution of three DMN subsystems to rumination. Results confirm the suspected association between rumination and DMN activation, specifically implicating the DMN core regions and the dorsal medial prefrontal cortex subsystem. Based on these findings, we suggest a hypothesis of how DMN regions support rumination and present the implications of this model for treating major depressive disorder characterized by rumination.
•Rumination is strongly and consistently correlated with depression.•Meta-analyze the findings of brain regions regarding to rumination.•Specifically examined the contribution of three DMN subsystems to rumination.•Rumination is specifically correlated with the DMN core regions and the dorsal medial prefrontal cortex subsystem. Rumination is strongly and consistently correlated with depression. Although multiple studies have explored the neural correlates of rumination, findings have been inconsistent and the mechanisms underlying rumination remain elusive. Functional brain imaging studies have identified areas in the default mode network (DMN) that appear to be critically involved in ruminative processes. However, a meta-analysis to synthesize the findings of brain regions underlying rumination is currently lacking. Here, we conducted a meta-analysis consisting of experimental tasks that investigate rumination by using Signed Differential Mapping of 14 fMRI studies comprising 286 healthy participants. Furthermore, rather than treat the DMN as a unitary network, we examined the contribution of three DMN subsystems to rumination. Results confirm the suspected association between rumination and DMN activation, specifically implicating the DMN core regions and the dorsal medial prefrontal cortex subsystem. Based on these findings, we suggest a hypothesis of how DMN regions support rumination and present the implications of this model for treating major depressive disorder characterized by rumination. Rumination is strongly and consistently correlated with depression. Although multiple studies have explored the neural correlates of rumination, findings have been inconsistent and the mechanisms underlying rumination remain elusive. Functional brain imaging studies have identified areas in the default mode network (DMN) that appear to be critically involved in ruminative processes. However, a meta-analysis to synthesize the findings of brain regions underlying rumination is currently lacking. Here, we conducted a meta-analysis consisting of experimental tasks that investigate rumination by using Signed Differential Mapping of 14 fMRI studies comprising 286 healthy participants. Furthermore, rather than treat the DMN as a unitary network, we examined the contribution of three DMN subsystems to rumination. Results confirm the suspected association between rumination and DMN activation, specifically implicating the DMN core regions and the dorsal medial prefrontal cortex subsystem. Based on these findings, we suggest a hypothesis of how DMN regions support rumination and present the implications of this model for treating major depressive disorder characterized by rumination.Rumination is strongly and consistently correlated with depression. Although multiple studies have explored the neural correlates of rumination, findings have been inconsistent and the mechanisms underlying rumination remain elusive. Functional brain imaging studies have identified areas in the default mode network (DMN) that appear to be critically involved in ruminative processes. However, a meta-analysis to synthesize the findings of brain regions underlying rumination is currently lacking. Here, we conducted a meta-analysis consisting of experimental tasks that investigate rumination by using Signed Differential Mapping of 14 fMRI studies comprising 286 healthy participants. Furthermore, rather than treat the DMN as a unitary network, we examined the contribution of three DMN subsystems to rumination. Results confirm the suspected association between rumination and DMN activation, specifically implicating the DMN core regions and the dorsal medial prefrontal cortex subsystem. Based on these findings, we suggest a hypothesis of how DMN regions support rumination and present the implications of this model for treating major depressive disorder characterized by rumination. |
ArticleNumber | 116287 |
Author | Shen, Yang-Qian Chen, Ning-Xuan Zhou, Hui-Xia Li, Le Castellanos, Francisco Xavier Yan, Chao-Gan Chen, Xiao Zhu, Zhi-Chen |
Author_xml | – sequence: 1 givenname: Hui-Xia surname: Zhou fullname: Zhou, Hui-Xia organization: CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China – sequence: 2 givenname: Xiao surname: Chen fullname: Chen, Xiao organization: CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China – sequence: 3 givenname: Yang-Qian surname: Shen fullname: Shen, Yang-Qian organization: CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China – sequence: 4 givenname: Le surname: Li fullname: Li, Le organization: CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China – sequence: 5 givenname: Ning-Xuan surname: Chen fullname: Chen, Ning-Xuan organization: CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China – sequence: 6 givenname: Zhi-Chen surname: Zhu fullname: Zhu, Zhi-Chen organization: CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China – sequence: 7 givenname: Francisco Xavier surname: Castellanos fullname: Castellanos, Francisco Xavier organization: Department of Child and Adolescent Psychiatry, Hassenfeld Children’s Hospital at NYU Langone, New York, NY, USA – sequence: 8 givenname: Chao-Gan surname: Yan fullname: Yan, Chao-Gan email: yancg@psych.ac.cn organization: CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31655111$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Brain Mapping Concrete Core regions Default mode network Depression Depression - diagnostic imaging Depression - physiopathology Dorsal medial prefrontal cortex subsystem Functional magnetic resonance imaging Humans Medical imaging Memory Mental depression Meta-analysis Nerve Net - diagnostic imaging Nerve Net - physiology Neuroimaging Prefrontal cortex Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - physiology Rumination Rumination, Cognitive - physiology Systematic review |
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Title | Rumination and the default mode network: Meta-analysis of brain imaging studies and implications for depression |
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