Statistical Dissection of Cyto-Nuclear Epistasis Subject to Genomic Imprinting in Line Crosses

• Published in: PloS one Vol. 9; no. 3; p. e91702
• Main Authors: He, Tao, Sa, Jian, Zhong, Ping-Shou, Cui, Yuehua
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.03.2014; Public Library of Science (PLoS)
• Subjects: Algorithms; Analysis; Animals; Biology and Life Sciences; Cell Nucleus - genetics; Computer and Information Sciences; Computer Simulation; Crosses, Genetic; Cytoplasm; Cytoplasm - genetics; Data processing; Deoxyribonucleic acid; Dissection; DNA; Epigenetics; Epistasis; Epistasis, Genetic; Estimation; Female; Gametes; Gene loci; Genetic control; Genetics; Genomes; Genomic Imprinting; Genomics; Genotype & phenotype; Imprinting; Inbreeding; Male; Mathematical models; Maximum likelihood estimates; Maximum likelihood method; Medical statistics; Metabolism; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mitochondria; Mitochondrial DNA; Models, Genetic; Nuclear interactions; Organelles; Parameter estimation; Performance evaluation; Physical Sciences; Physiological aspects; Public health; Quantitative Trait Loci; Statistical methods; Statistical models; Surgery; United States > US; East Lansing Michigan; Michigan

Cytoplasm contains important metabolism reaction organelles such as mitochondria and chloroplast (in plant). In particular, mitochondria contains special DNA information which can be passed to offsprings through maternal gametes, and has been confirmed to play a pivotal role in nuclear activities. E...