Characterization of histone modification patterns and prediction of novel promoters using functional principal component analysis

• Published in: PloS one Vol. 15; no. 5; p. e0233630
• Main Authors: Kim, Mijeong, Lin, Shili
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.05.2020; Public Library of Science (PLoS)
• Subjects: Acetylation; Algorithms; B cells; Binding; Biology and life sciences; Characterization; Chromatin; CpG islands; DNA methylation; Epigenetics; Gene expression; Gene regulation; Genes; Genetic regulation; Genetic research; Genomes; Genomics; Histones; Methylation; Nature; Novels; Physical Sciences; Post-translational modifications; Povidone; Principal components analysis; Promoters; Promoters (Genetics); Regulatory sequences; Research and Analysis Methods; Single-nucleotide polymorphism; Statistical inference; Structure; Transcription; Whole genome sequencing; United States; United States > US; Ohio

Characterization of distinct histone methylation and acetylation binding patterns in promoters and prediction of novel regulatory regions remains an important area of genomic research, as it is hypothesized that distinct chromatin signatures may specify unique genomic functions. However, methods tha...